Results 31 to 40 of about 98,446 (260)

Suppression of glucose-6-phosphate-isomerase induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands of glucose-6-phosphate-isomerase

Modern Rheumatology, 2017
To investigate the effects of transgenic rice seeds expressing the altered peptide ligand (APL) of human glucose-6-phosphate-isomerase (hGPI325-339) in mice model of GPI-induced arthritis (GIA).We generated transgenic rice expressing T-cell epitope of hGPI325-339 and APL12 contained in the seed endosperm.
T. Hirota, H. Tsuboi, Mana Iizuka-Koga, Hiroyuki Takahashi, H. Asashima, M. Yokosawa, Y. Kondo, Masaru Ohta, Y. Wakasa, I. Matsumoto, F. Takaiwa, T. Sumida   +11 more
semanticscholar   +3 more sources

Investigation on the Metabolic Regulation of pgi gene knockout Escherichia coli by Enzyme Activities and Intracellular Metabolite Concentrations [PDF]

Malaysian Journal of Microbiology, 2006
An integrated analysis of the cell growth characteristics, enzyme activities, intracellular metabolite concentrations was made to investigate the metabolic regulation of pgi gene knockout Escherichia coli based on batch culture and continuous culture ...
Nor ‘Aini, A. R., Shirai, Y., Hassan, M. A., Shimizu, K.   +3 more
doaj   +3 more sources

Allozymes of glucose-6-phosphate isomerase differentially modulate pentose-shunt metabolism in the sea anemone Metridium senile. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1989
We tested the hypothesis that kinetic differences among allelic variants of glucose-6-phosphate isomerase (GPI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) from the sea anemone Metridium senile differentially modulate glucose metabolism at the ...
William E. Zamer, Ruth Hoffmann
openalex   +2 more sources

RHBDF1 deficiency suppresses melanoma glycolysis and enhances efficacy of immunotherapy by facilitating glucose-6-phosphate isomerase degradation via TRIM32

Pharmacological Research, 2023
Melanoma is a dangerous form of skin cancer, making it important to investigate new mechanisms and approaches to enhance the effectiveness of treatment.
Lei Wang, Yuan-Yuan Song, Yan Wang, Xiu-Xiu Liu, Yi-Lun Yin, Shan Gao, Fan Zhang, Lu-Yuan Li, Zhi-Song Zhang   +8 more
doaj   +2 more sources

Activation of Invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis. [PDF]

PLoS ONE, 2012
OBJECTIVE: Invariant natural killer T (iNKT) cells regulate collagen-induced arthritis (CIA) when activated by their potent glycolipid ligand, alpha-galactosylceramide (α-GalCer). Glucose-6-phosphate isomerase (GPI)-induced arthritis is a closer model of
Masanobu Horikoshi, Daisuke Goto, Seiji Segawa, Yohei Yoshiga, Keiichi Iwanami, Asuka Inoue, Yuki Tanaka, Isao Matsumoto, Takayuki Sumida   +8 more
doaj   +2 more sources

Effects of Macromolecular Crowding on the Refolding of Glucose- 6-phosphate Dehydrogenase and Protein Disulfide Isomerase [PDF]

Journal of Biological Chemistry, 2001
The effects of polysaccharide, polyethylene glycol, and protein-crowding agents on the refolding of glucose-6-phosphate dehydrogenase (G6PDH) and protein disulfide isomerase have been examined. By increasing concentration during refolding, the reactivation yields of the two proteins decrease with the formation of soluble aggregates.
Jian Li, Sen Zhang, Chih-chen Wang
openalex   +5 more sources

The Accumulation of Glucose 6-Phosphate from Glucose and Its Effect in an Escherichia coli Mutant Lacking Phosphoglucose Isomerase and Glucose 6-Phosphate Dehydrogenase

Journal of Biological Chemistry, 1968
Abstract When presented with glucose, an Escherichia coli mutant lacking both phosphoglucose isomerase and glucose 6-phosphate dehydrogenase accumulated, internally, high concentrations (approximately 50 mm) of glucose 6-phosphate. It also accumulated glucose in polysaccharide form. Other metabolism of glucose, if any, was very restricted.
D G Fraenkel
openalex   +4 more sources

Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis [PDF]

Arthritis Research & Therapy, 2008
IntroductionImmunization with glucose-6-phosphate isomerase (GPI) induces severe arthritis in DBA/1 mice. The present study was designed to identify the cytokines and co-stimulatory molecules involved in the development of GPI-induced arthritis ...
Isao Matsumoto, Hua Zhang, Takanori Yasukochi, Keiichi Iwanami, Yoko Tanaka, Asuka Inoue, Daisuke Goto, Satoshi Ito, Akito Tsutsumi, Takayuki Sumida   +9 more
openalex   +2 more sources

Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide [PDF]

Arthritis Research & Therapy, 2009
Abstract Introduction Immunosuppressants, including anti-TNFα antibodies, have remarkable effects in rheumatoid arthritis; however, they increase infectious events. The present study was designed to examine the effects and immunological change of action of altered peptide ligands (APLs) on glucose-6 ...
Keiichi Iwanami, Isao Matsumoto, Yohei Yoshiga, Asuka Inoue, Yuya Kondo, Kayo Yamamoto, Yoko Tanaka, Reiko Minami, Taichi Hayashi, Daisuke Goto, Satoshi Ito, Yasuharu Nishimura, Takayuki Sumida   +12 more
openalex   +4 more sources

Immunization with Glucose-6-Phosphate Isomerase Induces T Cell-Dependent Peripheral Polyarthritis in Genetically Unaltered Mice [PDF]

Journal of Immunology, 2004
David Schubert, Bert Maier, Lars Morawietz, Veit Krenn, Thomas Kamradt   +4 more
openalex   +2 more sources