Results 21 to 30 of about 64,860 (226)

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide [PDF]

Arthritis Research & Therapy, 2009
Abstract Introduction Immunosuppressants, including anti-TNFα antibodies, have remarkable effects in rheumatoid arthritis; however, they increase infectious events. The present study was designed to examine the effects and immunological change of action of altered peptide ligands (APLs) on glucose-6 ...
Keiichi Iwanami, Isao Matsumoto, Yohei Yoshiga, Asuka Inoue, Yuya Kondo, Kayo Yamamoto, Yoko Tanaka, Reiko Minami, Taichi Hayashi, Daisuke Goto, Satoshi Ito, Yasuharu Nishimura, Takayuki Sumida   +12 more
core   +4 more sources

Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle [PDF]

Circulation Research, 2020
Rationale: Metabolic and structural remodeling is a hallmark of heart failure. This remodeling involves activation of the mTOR (mammalian target of rapamycin) signaling pathway, but little is known on how intermediary metabolites are integrated as metabolic signals.
Anja, Karlstaedt, Radhika, Khanna, Manoj, Thangam, Heinrich, Taegtmeyer   +3 more
openaire   +2 more sources

Relationship between glycolysis and exopolysaccharide biosynhesis in Lactococcus lactis [PDF]

, 2001
The relationships between glucose metabolism and exopolysaccharide (EPS) production in a Lactococcus lactis strain containing the EPS gene cluster (Eps ) and in nonproducer strain MG5267 (Eps) were characterized.
Ramos, A., Boels, I.C., Vos, W.M., de, Santos, H.   +3 more
core   +1 more source

Trypanosoma evansi is alike to Trypanosoma brucei brucei in the subcellular localisation of glycolytic enzymes

Memorias do Instituto Oswaldo Cruz, 2015
Trypanosoma evansi, which causes surra, is descended from Trypanosoma brucei brucei, which causes nagana. Although both parasites are presumed to be metabolically similar, insufficient knowledge of T. evansi precludes a full comparison.
S Andrea Moreno, Mayerly Nava
doaj   +1 more source

Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering [PDF]

, 2013
Background: The production of bioethanol from lignocellulose hydrolysates requires a robust, D-xylose-fermenting and inhibitor-tolerant microorganism as catalyst.
Boles, Eckhard, Bonini, Beatriz M., Demeke, Mekonnen M., Den Abt, Tom, Deprez, Sylvie, Dietz, Heiko, Dumortier, Francoise, Foulquie-Moreno, Maria R., Li, Yingying, Lidén, Gunnar,, Lund University., Mutturi, Sarma,, Thevelein, Johan M., Verplaetse, Alex   +13 more
core   +1 more source

Construction and Optimization of Biosynthetic Pathway for the Production of D-Allulose from Glucose in Escherichia coli [PDF]

Shipin Kexue
A pathway in Escherichia coli BL21 (DE3) was constructed to produce D-allulose from D-glucose via a phosphorylation-dephosphorylation strategy. The genes related to competitive pathways were deleted using the CRISPR/Cas9 system, and allulose-6-phosphate
JIANG Yawen, ZHANG Cangping, YANG Shaoqing, JIANG Zhengqiang, LI Yanxiao, YAN Qiaojuan
doaj   +1 more source

Fructose metabolism in Chromohalobacter salexigens: interplay between the Embden–Meyerhof–Parnas and Entner–Doudoroff pathways [PDF]

, 2019
Background The halophilic bacterium Chromohalobacter salexigens metabolizes glucose exclusively through the Entner–Doudoroff (ED) pathway, an adaptation which results in inefficient growth, with significant carbon overflow, especially at low salinity ...
Argandoña Bertrán, Montserrat, Bernal, Vicente, Borges, Nuno, Castaño Cerezo, Sara, Csonka, Laszlo N., Cánovas, Manuel, Gonçalves, Luís G., Goodner, Bradley W., Nieto Gutiérrez, Joaquín José, Pagán, Juan P., Pastor, José M., Reynolds, Kathryn A., Vargas Macías, Carmen   +12 more
core   +1 more source

Metabolic flexibilities and vulnerabilities in the pentose phosphate pathway of the zoonotic pathogen Toxoplasma gondii.

PLoS Pathogens, 2022
Metabolic pathways underpin the growth and virulence of intracellular parasites and are therefore promising antiparasitic targets. The pentose phosphate pathway (PPP) is vital in most organisms, providing a reduced form of nicotinamide adenine ...
Ningbo Xia, Xuefang Guo, Qinghong Guo, Nishith Gupta, Nuo Ji, Bang Shen, Lihua Xiao, Yaoyu Feng   +7 more
doaj   +1 more source

How are proteins reduced in the endoplasmic reticulum? [PDF]

, 2018
The reversal of thiol oxidation in proteins within the endoplasmic reticulum (ER) is crucial for protein folding, degradation, chaperone function, and the ER stress response. Our understanding of this process is generally poor but progress has been made.
Bulleid, Neil, Ellgaard, Lars, Sevier, Carolyn S.   +2 more
core   +2 more sources