Results 61 to 70 of about 65,595 (212)

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage. [PDF]

, 2016
In metabolism, available free energy is limited and must be divided across pathway steps to maintain a negative ΔG throughout. For each reaction, ΔG is log proportional both to a concentration ratio (reaction quotient to equilibrium constant) and to a ...
Amador-Noguez, Daniel, Fan, Jing, Park, Junyoung O, Rabinowitz, Joshua D, Rubin, Sara A, Shlomi, Tomer, Xu, Yi-Fan   +6 more
core   +2 more sources

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen, Wei Liu, Dan Zhou, Shuhua Liu, Yalun Guan, Zongyu Miao, Lei Cai, Xuejiao Li, Yunfeng Li, Zhongqiang Huang, Yi Jin, Ge Li, Yu Zhang   +12 more
wiley   +1 more source

Metabolic engineering of Pichia pastoris for myo-inositol production by dynamic regulation of central metabolism

Microbial Cell Factories, 2022
Background The methylotrophic budding yeast Pichia pastoris GS115 is a powerful expression system and hundreds of heterologous proteins have been successfully expressed in this strain. Recently, P.
Qiquan Zhang, Xiaolu Wang, Huiying Luo, Yaru Wang, Yuan Wang, Tao Tu, Xing Qin, Xiaoyun Su, Huoqing Huang, Bin Yao, Yingguo Bai, Jie Zhang   +11 more
doaj   +1 more source

Die Funktion des Responseregulators ARR2 in der Entwicklung von Arabidopsis thaliana [PDF]

, 2004
In dieser Arbeit konnte mittels physiologischer Experimente, Expressionsanalysen, Phosphorylierungsassays und Transaktivierungsanalysen eine komplexe Funktion von ARR2 in verschiedenen Signaltransduktionswegen von Arabidopsis aufgedeckt werden.
Haß, Claudia
core  

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Using phosphoglucose isomerase-deficient (pgi1Δ) Saccharomyces cerevisiae to map the impact of sugar phosphate levels on d-glucose and d-xylose sensing

Microbial Cell Factories, 2022
Background Despite decades of engineering efforts, recombinant Saccharomyces cerevisiae are still less efficient at converting d-xylose sugar to ethanol compared to the preferred sugar d-glucose.
Celina Borgström, Viktor C. Persson, Oksana Rogova, Karen O. Osiro, Ester Lundberg, Peter Spégel, Marie Gorwa-Grauslund   +6 more
doaj   +1 more source

Evaluation of rate law approximations in bottom-up kinetic models of metabolism. [PDF]

, 2016
BackgroundThe mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters.
A Bordbar, A Dräger, A Flamholz, A Joshi, A Kinoshita, AB Canelas, Andreas Dräger, AR Tzafriri, BD Bennett, Bernhard O. Palsson, Bin Du, BO Palsson, BO Palsson, C Chassagnole, D Visser, D Visser, DA Fell, Daniel C. Zielinski, E Noor, Erol S. Kavvas, F Hadlich, Garri A. Arzumanyan, GE Briggs, J Almquist, J Schellenberger, JJ Heijnen, JR Karr, Justin Tan, K Smallbone, K Takahashi, Kayla E. Ruggiero, KR Sanft, LA Segel, LA Segel, M Bier, M Salter, M Scheer, N Jamshidi, N Jamshidi, N Jamshidi, N Zamboni, O Kotte, PJ Mulquiney, R Grima, S Schnell, SA Becker, U Alon, W Liebermeister, Y-Y Liu, Zhen Zhang   +49 more
core   +4 more sources

Lifelong evolution of autoreactive plasma cell numbers, affinity and anatomical location in arthritic K/BxN mice

Arthritis &Rheumatology, Accepted Article.
Objective The spontaneous K/BxN mouse model of rheumatoid arthritis has been used extensively to study chronic inflammation, contribution of immune cells, and the primordial role of autoreactive antibodies in disease initiation and severity. Only the ubiquitous enzyme glucose‐6‐phosphate isomerase (GPI) is the target of IgG autoantibodies secreted by ...
Thibault Vanhoucke, Carlos Castrillon, Odile Richard‐Le Goff, Angga Perima, Matteo Broketa, Andrew D. Griffiths, Patrick England, François Huetz, Pierre Bruhns   +8 more
wiley   +1 more source

Esculetin Inhibits Cancer Cell Glycolysis by Binding Tumor PGK2, GPD2, and GPI

Frontiers in Pharmacology, 2020
Glycolysis can improve the tolerance of tissue cells to hypoxia, and its intermediates provide raw materials for the synthesis and metabolism of the tumor cells.
Song-Tao Wu, Bo Liu, Bo Liu, Bo Liu, Zhong-Zhu Ai, Zhong-Zhu Ai, Zhong-Zhu Ai, Zong-Chao Hong, Peng-Tao You, Peng-Tao You, Peng-Tao You, He-Zhen Wu, He-Zhen Wu, He-Zhen Wu, Yan-Fang Yang, Yan-Fang Yang, Yan-Fang Yang   +16 more
doaj   +1 more source

Evaluating the typing power of six isoenzymatic systems for differentiation of clinical and standard isolates of Candida species

Advanced Biomedical Research, 2023
Background: Due to the increasing prevalence of candidiasis, early detection of the causative agents may pave the way for the management of this infection.
Gholamreza Hatam, Hamid Morovati, Marzieh Alikhani, Amir Rahimi, Keyvan Pakshir, Sara Amini, Kamiar Zomorodian   +6 more
doaj   +1 more source