Results 61 to 70 of about 67,753 (222)

Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide [PDF]

Arthritis Research & Therapy, 2009
Abstract Introduction Immunosuppressants, including anti-TNFα antibodies, have remarkable effects in rheumatoid arthritis; however, they increase infectious events. The present study was designed to examine the effects and immunological change of action of altered peptide ligands (APLs) on glucose-6 ...
Keiichi Iwanami, Isao Matsumoto, Yohei Yoshiga, Asuka Inoue, Yuya Kondo, Kayo Yamamoto, Yoko Tanaka, Reiko Minami, Taichi Hayashi, Daisuke Goto, Satoshi Ito, Yasuharu Nishimura, Takayuki Sumida   +12 more
openalex   +4 more sources

Regulatory Functions of Nilaparvata lugens GSK-3 in Energy and Chitin Metabolism

Frontiers in Physiology, 2020
Glucose metabolism is a biologically important metabolic process. Glycogen synthase kinase (GSK-3) is a key enzyme located in the middle of the sugar metabolism pathway that can regulate the energy metabolism process in the body through insulin signaling.
Yan-Juan Ding, Yan-Juan Ding, Guo-Yong Li, Cai-Di Xu, Yan Wu, Zhong-Shi Zhou, Shi-Gui Wang, Can Li   +7 more
doaj   +1 more source

GPI: An indicator for immune infiltrates and prognosis of human breast cancer from a comprehensive analysis

Frontiers in Endocrinology, 2022
Glucose-6-phosphate isomerase (GPI) plays an important part in gluconeogenesis and glycolysis through the interconversion of d-glucose-6-phosphate and d-fructose-6-phosphate, and its clinical significance still remains unclear in breast cancer (BRCA). We
Jie Zeng, Jianing Yi, Siyi Tan, Yuanjun Zeng, Lianhong Zou, Chaojie Zhang, Luyao Liu, Pingyong Yi, Peizhi Fan, Jie Yu   +9 more
doaj   +1 more source

Phylogenetic analysis of the glucose-6-phosphate isomerase gene in Trypanosoma cruzi

Experimental Parasitology, 2006
Trypanosoma cruzi, the agent of Chagas disease, has a basically clonal population structure with rare hybridization events. The species is subdivided into six "Discrete Typing Units" called DTUs I, IIa-e, distributed into two major phylogenetic lineages, T. cruzi I and II (TC I and II).
/Broutin, Hélène, /Tarrieu, Frédérique, /Tibayrenc, Michel, /Oury, Bruno, /Barnabé, Christian   +4 more
openaire   +4 more sources

The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease

Anais da Academia Brasileira de Ciências, 2007
Trypanosoma cruzi is highly sensitive to oxidative stress caused by reactive oxygen species. Trypanothione, the parasite's major protection against oxidative stress, is kept reduced by trypanothione reductase, using NADPH; the major source of the reduced
Mariana Igoillo-Esteve, Dante Maugeri, Ana L. Stern, Paula Beluardi, Juan J. Cazzulo   +4 more
doaj   +1 more source

Reproductive strategies and genetic variability in tropical freshwater fish

Genetics and Molecular Biology, 2007
We estimated the genetic variability of nine fish species from the Brazilian upper Paraná River floodplain (Astyanax altiparanae, Hoplias malabaricus, Leporinus lacustris, Loricariichthys platymetopon, Parauchenipterus galeatus, Pimelodus maculatus ...
Maria Dolores Peres Lassala, Erasmo Renesto   +1 more
doaj   +1 more source

Activation of Invariant NKT cells with glycolipid ligand α-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis. [PDF]

PLoS ONE, 2012
OBJECTIVE: Invariant natural killer T (iNKT) cells regulate collagen-induced arthritis (CIA) when activated by their potent glycolipid ligand, alpha-galactosylceramide (α-GalCer). Glucose-6-phosphate isomerase (GPI)-induced arthritis is a closer model of
Masanobu Horikoshi, Daisuke Goto, Seiji Segawa, Yohei Yoshiga, Keiichi Iwanami, Asuka Inoue, Yuki Tanaka, Isao Matsumoto, Takayuki Sumida   +8 more
doaj   +1 more source

Síntese e modificações de derivados heterocíclicos de D-arabinose: potenciais inibidores de glicose-6-fosfato isomerase e de glicosamina-6-fosfato sintase Synthesis and modifications of heterocyclic derivatives of D-arabinose: potential inhibitors of glucose-6-phosphate isomerase and glucosamine-6-phosphate synthase

Química Nova, 2008
The synthesis of -5-(D-arabino-1,2,3,4-tetrahydroxybutyl)tetrazole and -2-(D-arabino-1,2,3,4-tetra-acetoxybutyl)-5-methyl-1,3,4-oxadiazole from D-arabinose is described.
Renato Márcio Ribeiro Viana, Maria Auxiliadora Fontes Prado, Ricardo José Alves   +2 more
doaj   +1 more source

GPI Is a Prognostic Biomarker and Correlates With Immune Infiltrates in Lung Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundGlucose-6-phosphate isomerase (GPI) plays an important role in glycolysis and gluconeogenesis. However, the role of GPI in lung adenocarcinoma (LUAD) remains unclear.MethodsAll original data were downloaded from The Cancer Genome Atlas (TCGA ...
Jiahui Han, Jiahui Han, Xinzhou Deng, Xinzhou Deng, Renhuang Sun, Ming Luo, Meng Liang, Bing Gu, Te Zhang, Zhen Peng, Ying Lu, Chao Tian, Yutao Yan, Zhiguo Luo, Zhiguo Luo   +14 more
doaj   +1 more source

Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

Advanced Science, EarlyView.
The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu, Pengling Wei, Lirong Chen, Ling Gao, Xiaole Xia   +4 more
wiley   +1 more source