Results 131 to 140 of about 3,377,180 (268)

Evaluation of a rare glucose-dependent insulinotropic polypeptide receptor variant in a patient with diabetes

, 2019
AIMS: Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that augments insulin secretion in pancreatic β-cells via its glucose-dependent insulinotropic polypeptide receptor (GIPR).
Völzke, H., Alexander Teumer, Völzke, Henry, Kühnen, Peter, Khajavi, Noushafarin, Kleinau, G., Susanna Wiegand, Wiegand, S., Gong, M., Gunnar Kleinau, Homuth, G., Heike Biebermann, Scheerer, Patrick, Jacobi, S.F., Kühnen, P., Henry Völzke, Homuth, Georg, Kleinau, Gunnar, Georg Homuth, Maolian Gong, Patrick Scheerer, Simon F. Jacobi, Scheerer, P., Teumer, A., Biebermann, H., Peter Kühnen, Jacobi, Simon F., Noushafarin Khajavi, Raile, K., Raile, Klemens, Teumer, Alexander, Krude, Heiko, Khajavi, N., Biebermann, Heike, Krude, H., Klemens Raile, Gong, Maolian, Heiko Krude, Wiegand, Susanna   +38 more
core   +1 more source

Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?

Journal of Internal Medicine, EarlyView.
Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello, Emelie Barreby, Umberto Vespasiani‐Gentilucci, Stefano Romeo   +3 more
wiley   +1 more source

Low Weight Loss Response to Incretin Analogs: A Systematic Review

Obesity Reviews, EarlyView.
ABSTRACT The development of GLP‐1 and GIP analogs has been a significant breakthrough in type 2 diabetes and obesity pharmacotherapy. However, individual responses to these medications can vary widely. This systematic review examines factors associated with low or no weight loss response to GLP‐1 and GIP analogs. Key predictors of poor response include
Pamela S. Gaskin, Peter S. Chami
wiley   +1 more source

Glucose-dependent insulinotropic polypeptide lowers branched chain amino acids in hyperglycemic rats.

, 2014
Hypersecretion of the incretin hormone glucose-dependent insulinotropic polypeptide (GIP) has been associated with obesity and glucose intolerance. This condition has been suggested to be linked to GIP resistance.
Wierup, Nils, Lindqvist, Andreas, Sandberg, Monica,, Sandberg, Monica, Spégel, Peter   +4 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits

, 2012
Heritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin,
Ekstrøm, Claus Thorn, Pedersen, Oluf, Hansen, Torben, Eiberg, Hans Rudolf Lytchoff, Gjesing, Anette Marianne Prior, Hansen, Teis, Holst, Jens Juul, Urhammer, Søren, Urhammer, S.A.   +8 more
core   +1 more source

Improved Glucagon Sensitivity Following Weight Loss: A Systematic Review and Meta‐Analysis

Obesity Reviews, EarlyView.
ABSTRACT Objective This systematic review and meta‐analysis investigated the effect of weight loss in people with obesity on two biomarkers of glucagon resistance: fasting plasma glucagon and alanine. Methods A comprehensive search was conducted in Medline and Embase. Random‐effects meta‐analyses and correlation analyses were performed.
Hye‐Rin Charlotte Kim, Lima Hamidi, Anne Majumdar, Matyas Fehervari, Emma Rose McGlone   +4 more
wiley   +1 more source

Glucose-dependent insulinotropic polypeptide receptor agonism improves heart failure with antifibrosis through Akt-dependent nitric oxide signaling

Journal of Biomedical Science
Background Cardiac fibrosis is a pathological remodeling process that contributes to the development and progression of heart failure. Although glucose-dependent insulinotropic polypeptide (GIP) may exert antifibrotic effects, how GIP receptor activation
Ting-Wei Lee, Ting-I Lee, Satoshi Higa, Yu-Hsun Kao, Yi-Jen Chen   +4 more
doaj   +1 more source

Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions

, 2018
Nine structurally modified apelin-13 analogues were assessed for their in vitro and acute in vivo antidiabetic potential. Stability was assessed in mouse plasma and insulinotropic efficacy tested in cultured pancreatic BRIN-BD11 cells and isolated mouse ...
O'Harte, Finbarr P. M., P.R. Flatt, Parthsarathy, Vadivel, Hogg, Christopher, Flatt, Peter R., F.P.M. O’Harte, C. Hogg, V. Parthsarathy   +7 more
core   +1 more source

Incretin‐Based Medications in Women and Reproduction: A Systematic Scoping Review and Consensus Guidelines for Clinical Practice

Obesity Reviews, EarlyView.
ABSTRACT Introduction Pregnancy concurrent with incretin‐based medications is contraindicated due to unknown risk of teratogenicity, as is breastfeeding. The aim of this systematic scoping review was to investigate potential risks and benefits of incretin‐based medications in relation to preconception, pregnancy, and postnatal health, and to propose ...
Kate Maslin, Jill Shawe, Sinead Blowers, Michael Ceulemans, Kathryn Hart, Sam Schoenmakers, Amihai Rottenstreich, Heather Hopper, Mojca Jensterle, Angela C. Flynn, Sarah Siegelaar, Annick Bogaerts, Isy Douek, Nicola Heslehurst, Dries Ceulemans, Tricia Tan, Johnathan Pinkney, Martin Whyte, Shahrad Taheri, Roland Devlieger   +19 more
wiley   +1 more source