Results 181 to 190 of about 13,497 (214)
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The pharmacokinetics of porcine glucose‐dependent insulinotropic polypeptide (GIP) in man
European Journal of Clinical Investigation, 1982Abstract. The pharmacokinetics of porcine glucose‐dependent insulinotropic polypeptide were investigated in six healthy volunteers. At the maximum infusion dose (0·5 pmol kg‐1 min‐1) a plateau concentration of 115 ± 5·0 pmol/l plasma was obtained. On discontinuation of the infusion, the half‐time of disappearance was calculated to be 20·3 ± 1·2 min ...
D L, Sarson, R C, Hayter, S R, Bloom
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Evolution of the vertebrate glucose-dependent insulinotropic polypeptide (GIP) gene
Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 2006The glucose-dependent insulinotropic polypeptide (GIP) gene is believed to have originated from a gene duplication event very early in vertebrate evolution that also produced the proglucagon gene, yet so far GIP has only been described within mammals. Here we report the identification of GIP genes in chicken, frogs, and zebrafish.
David M, Irwin, Tony, Zhang
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Regulation of glucose-dependent insulinotropic polypeptide release by protein in the rat
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000Glucose-dependent insulinotropic polypeptide (GIP) release has been demonstrated predominantly after ingestion of carbohydrate and fat. These studies were conducted to determine the effects of protein on GIP expression in the rat. Whereas no significant changes in duodenal mucosal GIP mRNA levels were detected in response to peptone, the duodenal GIP ...
M M, Wolfe +4 more
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Functional analysis of glucose-dependent insulinotropic polypeptide fusion proteins
Peptides, 2001To generate functional fluorescently tagged glucose-dependent insulinotropic polypeptide (GIP), a series of GIP expression constructs were devised. These included G1 (complete preprohormone), G2 (lacking the C-terminal extension), G3 (lacking both N- and C-terminal extensions), G4 (G2 fused to green fluorescent protein, GFP), and G5 (G3 fused to GFP ...
K H, Ding +3 more
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Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2010Glucose-dependent insulinotropic polypeptide (GIP) is a hormone released from enteroendocrine K cells in response to meals. Posttranslational processing of the precursor protein pro-GIP at residue 65 by proprotein convertase subtilisin/kexin type 1 (PC1/3) in gut K cells gives rise to the established 42-amino-acid form of GIP (GIP1–42).
Yukihiro, Fujita +4 more
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Glucose-dependent insulinotropic polypeptide augmentation of insulin. Physiology or pharmacology?
Diabetes, 1984Glucose-dependent insulinotropic polypeptide (GIP) is said to be a major physiologic factor in the augmentation of the insulin response to oral glucose. Whether GIP promotes insulin release at physiologic concentrations of glucose or GIP, however, is questionable.
D L, Sarson +3 more
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Journal of Neuroscience Research, 2007
AbstractWe have previously demonstrated that glucose‐dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is present in the adult rat hippocampus. This finding leads to the conclusion that all members of the secretin‐glucagon family of gastrointestinal regulatory polypeptides can be found in the brain.
Jenny, Nyberg +3 more
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AbstractWe have previously demonstrated that glucose‐dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is present in the adult rat hippocampus. This finding leads to the conclusion that all members of the secretin‐glucagon family of gastrointestinal regulatory polypeptides can be found in the brain.
Jenny, Nyberg +3 more
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On the mechanism of action of glucose-dependent insulinotropic polypeptide
2010The interaction of the intestinal insulinotropic hormone GIP (Glucose-dependent Insulinotropic Polypeptide or Gastric Inhibitory Polypeptide) with the stimulus-secretion coupling mechanism of glucose-induced insulin secretion was investigated using the isolated, perfused, rat pancreas technique. The action of GIP in potentiating insulin secretion which
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Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP).
Vitamins and hormones, 2009Glucose-dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is a 42 amino acid hormone that is produced by enteroendocrine K-cells and released into the circulation in response to nutrient stimulation. Both GIP and glucagon-like peptide-1 (GLP-1) stimulate insulin secretion in a glucose-dependent manner and are thus classified as
Christopher H S, McIntosh +2 more
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Alterations of glucose-dependent insulinotropic polypeptide (GIP) during cold acclimation
Regulatory Peptides, 2011Cold acclimation is initially associated with shivering thermogenesis in skeletal muscle followed by adaptive non-shivering thermogenesis, particularly in brown adipose tissue (BAT). In response, hyperphagia occurs to meet increased metabolic demand and thermoregulation.
N, Irwin, J M E, Francis, P R, Flatt
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