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Regulation of glucose-dependent insulinotropic polypeptide release by protein in the rat
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000Glucose-dependent insulinotropic polypeptide (GIP) release has been demonstrated predominantly after ingestion of carbohydrate and fat. These studies were conducted to determine the effects of protein on GIP expression in the rat. Whereas no significant changes in duodenal mucosal GIP mRNA levels were detected in response to peptone, the duodenal GIP ...
M M, Wolfe +4 more
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Structure-Activity Relationships of Glucose-Dependent Insulinotropic Polypeptide (GIP)
Biological Chemistry, 2003Six GIP(1-NH2) analogs were synthesized with modifications (de-protonation, N-methylation, reversed chirality, and substitution) at positions 1, 3, and 4 of the N-terminus, and additionally, a cyclized GIP derivative was synthesized. The relationship between altered structure to biological activity was assessed by measuring receptor binding affinity ...
Simon A, Hinke +9 more
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Differential processing of pro-glucose-dependent insulinotropic polypeptide in gut
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2010Glucose-dependent insulinotropic polypeptide (GIP) is a hormone released from enteroendocrine K cells in response to meals. Posttranslational processing of the precursor protein pro-GIP at residue 65 by proprotein convertase subtilisin/kexin type 1 (PC1/3) in gut K cells gives rise to the established 42-amino-acid form of GIP (GIP1–42).
Yukihiro, Fujita +4 more
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Glucose-dependent insulinotropic polypeptide augmentation of insulin. Physiology or pharmacology?
Diabetes, 1984Glucose-dependent insulinotropic polypeptide (GIP) is said to be a major physiologic factor in the augmentation of the insulin response to oral glucose. Whether GIP promotes insulin release at physiologic concentrations of glucose or GIP, however, is questionable.
D L, Sarson +3 more
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K-cells and Glucose-Dependent Insulinotropic Polypeptide in Health and Disease
2010In the 1970s, glucose-dependent insulinotropic polypeptide (GIP, formerly gastric inhibitory polypeptide), a 42-amino acid peptide hormone, was discovered through a search for enterogastrones and subsequently identified as an incretin, or an insulinotropic hormone secreted in response to intraluminal nutrients.
Young Min, Cho, Timothy J, Kieffer
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On the mechanism of action of glucose-dependent insulinotropic polypeptide
2010The interaction of the intestinal insulinotropic hormone GIP (Glucose-dependent Insulinotropic Polypeptide or Gastric Inhibitory Polypeptide) with the stimulus-secretion coupling mechanism of glucose-induced insulin secretion was investigated using the isolated, perfused, rat pancreas technique. The action of GIP in potentiating insulin secretion which
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Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP).
Vitamins and hormones, 2009Glucose-dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is a 42 amino acid hormone that is produced by enteroendocrine K-cells and released into the circulation in response to nutrient stimulation. Both GIP and glucagon-like peptide-1 (GLP-1) stimulate insulin secretion in a glucose-dependent manner and are thus classified as
Christopher H S, McIntosh +2 more
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Glucose-Dependent Insulinotropic Polypeptide (GIP)
1999M. Michael Wolfe +3 more
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