Results 101 to 110 of about 4,211,438 (402)
Postnatal β2 adrenergic treatment improves insulin
sensitivity in lambs with IUGR but not persistent defects
in pancreatic islets or skeletal muscle [PDF]
, 2019 Placental insufficiency causes intrauterine growth restriction (IUGR) and disturbances in glucose homeostasis with associated β adrenergic receptor (ADRβ) desensitization.Allen, Ronald E., Anderson, Miranda J., Antolic, Andrew T., Camacho, Leticia E., Davis, Melissa A., Goyal, Ravi, Hay, William W., Jr, Kelly, Amy C., Limesand, Sean W., Papas, Klearchos K., Steyn, Leah V., Yates, Dustin T. +11 morecore +1 more sourceEscape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk +11 morewiley +1 more sourceAssociation of pre-diabetes with the risks of adverse health outcomes and complex multimorbidity: evidence from population-based studies in the NIS and UK Biobank
BMJ Public HealthIntroduction This study aimed to examine the risk of common diseases among people with pre-diabetes and explored the relationship between pre-diabetes and multimorbidity (in this case, two or more comorbid diseases).Methods An observational multicohort ...Yue Zhang, Jiajun Zhao, Zhongshang Yuan, Hang Dong, Mingzhuo Li, Yingzhou Shi, Yafei Wu, Xiude Fan, Zinuo Yuan, Junming Han, Yiping Cheng, Xiaoshan Feng, Zhixiang Wang, Ruirui Xuan, Yingchun Dong, Yang Tian, Qingling Guo, Yongfeng Song +17 moredoaj +1 more source2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
International Journal of Molecular Sciences, 2019 The ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival.Beata Pająk, E. Siwiak, M. Sołtyka, A. Priebe, Rafal Zieliński, I. Fokt, M. Ziemniak, A. Jaśkiewicz, R. Borowski, Tomasz Domoradzki, W. Priebe +10 moresemanticscholar +1 more sourceGlucose Variability [PDF]
Diabetes, 2013 The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia.openaire +2 more sourcesTargeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker +19 morewiley +1 more sourceGlucose Content of Sago Waste After Chloride Acid Pre- Treatment Hydrolysis For Bioethanol Production [PDF]
, 2015 Indonesia is a country with abundant agricultural biological resources. One of the plants as a biological source is sago. Sago processing wastes such as bark and waste about 72%.A, Agustina LN, Djaelani, M.Anwar, Kusdyantini, Endang, Prihastanti, Erma, Sasongko, Priyo Sidik, Setyawan , Agus, Widowati, W. +6 morecore Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam +14 morewiley +1 more sourceAssociation of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis
Lipids in Health and DiseaseBackground and objective This study evaluated the associations of the triglyceride-glucose (TyG) index or its attendant parameters, known as reliable measures of insulin resistance, with asymptomatic intracranial arterial stenosis (aICAS), along with ...Yumeng Yang, Liying Guo, Shiqing Song, Xianglong Kong, Yuanyuan Zhao, Xiaotong Ma, Xiang Wang, Hailing Wang, Qinjian Sun +8 moredoaj +1 more sourceNew genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Nature Genetics, 2010 Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fasting glucose, fasting insulin and indices of beta-cell function ...J. Dupuis, C. Langenberg, I. Prokopenko, R. Saxena, N. Soranzo, A. Jackson, E. Wheeler, N. Glazer, N. Bouatia-Naji, A. Gloyn, C. Lindgren, R. Mägi, A. Morris, J. Randall, T. Johnson, P. Elliott, Denis Rybin, G. Thorleifsson, V. Steinthorsdottir, P. Henneman, H. Grallert, A. Dehghan, J. Hottenga, C. Franklin, P. Navarro, Kijoung Song, A. Goel, J. Perry, J. Egan, T. Lajunen, N. Grarup, T. Sparsø, A. Doney, B. Voight, H. Stringham, Man Li, S. Kanoni, P. Shrader, Christine Cavalcanti-Proença, M. Kumari, L. Qi, N. Timpson, C. Gieger, C. Zabena, G. Rocheleau, E. Ingelsson, P. An, J. O’Connell, J. Luan, A. Elliott, S. Mccarroll, F. Payne, R. Roccasecca, F. Pattou, P. Sethupathy, K. Ardlie, Y. Ariyurek, B. Balkau, P. Barter, J. Beilby, Y. Ben-Shlomo, R. Benediktsson, A. Bennett, S. Bergmann, M. Bochud, E. Boerwinkle, A. Bonnefond, L. Bonnycastle, K. Borch-Johnsen, Y. Böttcher, E. Brunner, S. Bumpstead, G. Charpentier, Y. Chen, P. Chines, R. Clarke, L. Coin, M. Cooper, M. Cornelis, Gabriel J Crawford, L. Crisponi, I. Day, E. D. de Geus, J. Delplanque, C. Dina, M. Erdos, A. Fedson, A. Fischer-Rosinský, N. Forouhi, C. Fox, R. Frants, M. Franzosi, P. Galan, M. Goodarzi, J. Graessler, C. Groves, S. Grundy, R. Gwilliam, U. Gyllensten, S. Hadjadj, G. Hallmans, Naomi Hammond, Xijing Han, A. Hartikainen, N. Hassanali, C. Hayward, S. Heath, S. Hercberg, C. Herder, A. Hicks, D. Hillman, A. Hingorani, A. Hofman, J. Hui, J. Hung, B. Isomaa, P. Johnson, T. Jørgensen, A. Jula, M. Kaakinen, J. Kaprio, Y. Kesaniemi, M. Kivimaki, B. Knight, S. Koskinen, P. Kovacs, K. Kyvik, G. Lathrop, D. Lawlor, O. Le Bacquer, C. Lecoeur, Yun Li, V. Lyssenko, R. Mahley, M. Mangino, A. Manning, M. Martínez-Larrad, J. Mcateer, L. McCulloch, R. McPherson, C. Meisinger, D. Melzer, D. Meyre, B. Mitchell, M. Morken, S. Mukherjee, S. Naitza, Narisu Narisu, M. Neville, B. Oostra, M. Orrù, R. Pakyz, C. Palmer, G. Paolisso, C. Pattaro, Daniel S Pearson, J. Peden, N. Pedersen, M. Perola, A. Pfeiffer, I. Pichler, O. Polašek, D. Posthuma, Simon C. Potter, A. Pouta, M. Province, B. Psaty, W. Rathmann, N. W. Rayner, K. Rice, S. Ripatti, F. Rivadeneira, M. Roden, O. Rolandsson, A. Sandbaek, M. Sandhu, S. Sanna, A. Sayer, P. Scheet, L. Scott, U. Seedorf, S. Sharp, B. Shields, G. Sigurðsson, E. J. G. Sijbrands, A. Silveira, Laila Simpson, A. Singleton, N. Smith, U. Sovio, A. Swift, H. Syddall, A. Syvänen, Toshiko Tanaka, B. Thorand, J. Tichet, A. Tönjes, T. Tuomi, A. Uitterlinden, K. W. van Dijk, M. van Hoek, Dhiraj Varma, S. Visvikis-Siest, V. Vitart, N. Vogelzangs, G. Waeber, Peter J Wagner, A. Walley, G. Walters, K. Ward, H. Watkins, M. Weedon, S. Wild, G. Willemsen, J. Witteman, J. Yarnell, E. Zeggini, D. Zélénika, B. Zethelius, G. Zhai, J. Zhao, M. Zillikens, I. Borecki, R. Loos, P. Meneton, P. Magnusson, D. Nathan, G. Williams, A. Hattersley, K. Silander, V. Salomaa, G. Smith, S. Bornstein, P. Schwarz, J. Spranger, F. Karpe, A. Shuldiner, C. Cooper, G. Dedoussis, M. Serrano-Ríos, A. Morris, L. Lind, L. Palmer, F. Hu, P. Franks, S. Ebrahim, M. Marmot, W. Kao, J. Pankow, M. Sampson, J. Kuusisto, M. Laakso, T. Hansen, O. Pedersen, P. Pramstaller, H. Wichmann, T. Illig, I. Rudan, A. Wright, M. Stumvoll, H. Campbell, James F. Wilson, A. Hamsten, R. Bergman, T. Buchanan, F. Collins, K. Mohlke, J. Tuomilehto, T. Valle, D. Altshuler, J. Rotter, D. Siscovick, B. Penninx, D. Boomsma, P. Deloukas, T. Spector, T. Frayling, L. Ferrucci, A. Kong, U. Thorsteinsdóttir, K. Stefánsson, C. V. van Duijn, Y. Aulchenko, A. Cao, A. Scuteri, D. Schlessinger, M. Uda, A. Ruokonen, M. Jarvelin, D. Waterworth, P. Vollenweider, L. Peltonen, V. Mooser, G. Abecasis, N. Wareham, R. Sladek, P. Froguel, R. Watanabe, J. Meigs, L. Groop, M. Boehnke, M. McCarthy, J. Florez, I. Barroso +303 moresemanticscholar +1 more source
