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Acute activation of glucose uptake by glucose deprivation in L929 fibroblast cells
Biochimie, 2006Glucose is a very important energy source for a wide variety of cells, and the ability of cells to respond to changes in glucose availability or other cell stresses is of critical importance. Many mammalian cells respond to acute stress by increasing the V(max) of transport through GLUT1; the most ubiquitously expressed glucose transporter isoform ...
Brian, Roelofs +5 more
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Effects of Glucose Deprivation or Glucose Instability on Mesangial Cells in Culture
American Journal of Nephrology, 2008Mesangial cell (MC) abnormalities play a central role in diabetic nephropathy. Variations in plasma glucose levels may contribute to MC dysfunction. This study evaluated the effects of glucose deprivation or fluctuations on MC viability, glucose uptake, and mesangial matrix production. The expression levels of fibronectin and glucose transporters (GLUT-
Carla, de Lima E Santos +3 more
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Stabilization of glucose transporter mRNA by insulin/IGF-1 and glucose deprivation
Biochemical and Biophysical Research Communications, 1990Chronic exposure of L6 myocytes to insulin/IGF-1 or glucose deprivation results in an increase in the level of brain-type glucose transporter (GLUT1) mRNA. We have investigated the effects of insulin and glucose deprivation on GLUT1 mRNA stability. The half-life of GLUT1 mRNA in control cells was 2-2.5 h. Insulin increased GLUT1 mRNA levels by 5- to 10-
F, Maher, L C, Harrison
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HspB8 is Neuroprotective during Oxygen Glucose Deprivation and Reperfusion
Current Neurovascular Research, 2015Heat shock protein B8 (HspB8) is a chaperone protein that is highly and constitutively expressed in the brain, cardiac tissue and many other organs. Recently, it has been shown that HspB8 can enhance cardiac function and render cardioprotection. However, the potential benefits of HspB8 action on ischemic stroke and the underlying mechanism(s) are ...
Binbin, Yang +4 more
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Ethanol and glucose-deprivation neurotoxicity in cortical cell cultures
Metabolism, 1994The toxic effects of ethanol on rat cortical cell cultures were compared with neuronal damage induced by glucose deprivation. Exposure to decreased glucose concentrations produced dose-dependent neuronal injury, as indicated by the release of lactate dehydrogenase (LDH) into the culture medium.
S P, Singh, S, Ehmann, A K, Snyder
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Killing of Glucose-Deprived Hypoxic Cells with Moderate Hyperthermia
Radiation Research, 1978Investigations were carried out to determine the importance of glucose as a modifying factor for hyperthermic cellular damage. HeLa S-3 cells were heated under oxic and hypoxic conditions, in the presence and absence of D-glucose. Temperatures as low as 41?C selectively enhanced killing of the glucose deprived hypoxic cell. Glucose deprivation (37?C, 2
J H, Kim, S H, Kim, E W, Hahn
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Pathways Involved in Oxygen Glucose Deprivation Damage of Astrocytes
Journal of Molecular Neuroscience, 2016This present paper focus on transcriptome changes of astrocytes before and after oxygen glucose deprivation (OGD) injury. Cortical astrocytes of Sprague-Dawley (SD) rats were cultured in OGD condition for 6 h, and the damage of cells was analyzed by cell's activity detection, lactate dehydrogenase leakage rate detection, annexin V-FITC (fluorescein ...
Shuyong, Wei +4 more
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Glucagon Release: Paradoxical Stimulation by Glucose During Calcium Deprivation
Science, 1975During calcium deprivation, the rate of glucagon release by the isolated perfused rat pancreas is positively related to the glucose concentration of the perfusion medium. It is suggested that such a paradoxical behavior, which is reminiscent of the abnormality of glucagon secretion recently disclosed in diabetic subjects, results from a perturbation in
Leclercq Meyer, Viviane +3 more
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Hypoxic Cell Radiosensitization by Moderate Hyperthermia and Glucose Deprivation
Radiation Research, 1983Cell culture studies were carried out to determine whether moderate hyperthermia reduces the oxygen enhancement ratio of cells under well-defined cultural conditions. Using asynchronously growing HeLa cells, the OER of cells with and without glucose was determined following exposure of cells to moderate hyperthermia, 40.5 degrees C for 1 hr ...
J H, Kim, S H, Kim, E W, Hahn
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