Results 181 to 190 of about 590,245 (355)

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Human glycogenins maintain glucose homeostasis by regulating glycogen metabolism. [PDF]

Nat Commun
Weng TH, Pien YC, Chen CJ, Chen PP, Tseng YT, Chen YC, Hsiao WP, Lee YT, Chen YA, Chen YC, Lim C, Hsu TH, Lin SJ, Yen HY, Hsia KC, Tsai SY.   +15 more
europepmc   +1 more source

Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activate hepatic gluconeogenesis

Molecular Metabolism
The circadian clock regulates tissue-specific homeostasis, and its disruption is associated with metabolic disorders. Both host metabolic processes and the gut microbiota exhibit diurnal regulation, and both contribute to the maintenance of glucose ...
Jian Tan, Jemma Justine Taitz, Duan Ni, Camille Potier-Villette, Gabriela Pinget, Tamara Pulpitel, Dragana Stanley, Ralph Nanan, Laurence Macia   +8 more
doaj  

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Molecular dissection of the role of ACE2 in glucose homeostasis. [PDF]

Physiol Rev
Chhabra KH, Shoemaker R, Herath CB, Thomas MC, Filipeanu CM, Lazartigues E.   +5 more
europepmc   +1 more source

Foxa3 (Hepatocyte Nuclear Factor 3γ) Is Required for the Regulation of Hepatic GLUT2 Expression and the Maintenance of Glucose Homeostasis during a Prolonged Fast [PDF]

, 2001
Wei Shen, L. Marie Scearce, John Brestelli, Newman J. Sund, Klaus H. Kaestner   +4 more
openalex   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Glucose homeostasis and cognitive functions in schizophrenia: a systematic review and meta-analysis. [PDF]

Sci Rep
Kancsev A, Virág-Tulassay EÉ, Engh MA, Kiss-Dala S, Horváth AA, Hegyi P, Kéri S.   +6 more
europepmc   +1 more source

Limited Value of the Homeostasis Model Assessment to Predict Insulin Resistance in Older Men With Impaired Glucose Tolerance [PDF]

, 2001
Cynthia M. Ferrara, Andrew P. Goldberg
openalex   +1 more source

NAD+‐Boosters Improve Mitochondria Quality Control In Parkinson's Disease Models Via Mitochondrial UPR

Advanced Science, EarlyView.
Treatment of MPTP‐incubated cells with NAD+‐boosters increase the UPRmt/mitophagy‐related mitochondria quality control (MQC). Disturbed plasma UPRmt‐mitophagy‐mediated MQC profiles in PD patient samples. NMN inhibits motor deficit and forestalls neuropathology phenotypes of PD mice, which is required the atf4‐medicated UPRmt pathway.
Shuoting Zhou, Xi Xiong, Jialong Hou, Qi Duan, Yi Zheng, Tao Jiang, Jiani Huang, Haijun He, Jiaxue Xu, Keke Chen, Wenwen Wang, Jinlai Cai, Jingjing Qian, Huijun Chen, Weihong Song, XinShi Wang, Chenglong Xie   +16 more
wiley   +1 more source