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Central Regulation of Glucose Homeostasis

Comprehensive Physiology, 2017
ABSTRACT The ability of the brain to directly control glucose levels in the blood independently of its effects on food intake and body weight has been known ever since 1854 when Claude Bernard, a French physiologist, discovered that lesioning the floor of the fourth ventricle in rabbits led to a rise of sugar in ...
Tups A.   +4 more
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The glucose homeostasis test

The American Journal of Digestive Diseases, 1955
The diagnosis of functional hyperinsulinism would be made more frequently if the test for that condition were made more reliable and less confusing. It is proposed that the test be called “the glucose homeostasis test” rather than the currently used expression, “six hour glucose tolerance test” because the former term is actually what is determined ...
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Neonatal Glucose Homeostasis

Neonatal Network, 2008
NEWBORNS ARE NURTURED in a uterine environment that provides and regulates their glucose supply. Once the umbilical cord is clamped and the maternal glucose supply is terminated, the neonate must begin glucose regulation. This regulation involves complex metabolic and hormonal pathways that may not be mature immediately after birth.
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Mechanisms of blood glucose homeostasis

Journal of Inherited Metabolic Disease, 1990
SummaryThe mechanisms by which glycogen metabolism, glycolysis and gluconeogenesis are controlled in the liver both by hormones and by the concentration of glucose are reviewed. The control of glycogen metabolism occurs by phosphorylation and dephosphorylation of both glycogen phosphorylase and glycogen synthase catalysed by various protein kinases and
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Polyphenols and Glucose Homeostasis in Humans

Journal of the Academy of Nutrition and Dietetics, 2012
Summary of intervention trials examining the effects of tea consumption on glucose metabolism Author(s), year,reference Study design Intervention Participants Follow-up Measurements ResultsAdverseeventsJosic andcolleagues,2010 28 Randomized,crossover, nonblind300 mL green tea, totalcatechin dose 202 mg,given with test mealn14 (50% men)Age 273yBMI a 22 ...
Martin, de Bock   +2 more
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Genetic determinants of glucose homeostasis

Best Practice & Research Clinical Endocrinology & Metabolism, 2012
Type 2 diabetes is a complex metabolic disorder characterised by varying degrees of impairment in insulin secretion and resistance to the action of insulin. Considerable progress has been made recently in understanding the genetic determinants of diabetes. A logical next step is to describe how these variants relate to the underlying pathophysiological
Adam, Barker   +2 more
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Influence of Ageing on Glucose Homeostasis*

The Journal of Clinical Endocrinology & Metabolism, 1982
The mechanism of age-related glucose intolerance was investigated by comparing forearm glucose uptake (FGU) during 100-g oral glucose tolerance tests (GTTs) in healthy men of different ages: group Y, 19–24 yr (n = 11); group M, 30–45 yr (n = 12); and group E, 70–83 yr (n = 9).
R A, Jackson   +8 more
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Hepatocytes: critical for glucose homeostasis

The International Journal of Biochemistry & Cell Biology, 2004
Maintaining blood glucose levels within a narrow range is a critical physiological function requiring multiple metabolic pathways and involving several cell types, including a prominent role for hepatocytes. Under hormonal control, hepatocytes can respond to either feeding or fasting conditions by storing or producing glucose as necessary.
Peter J, Klover, Robert A, Mooney
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The Genetic Basis of Glucose Homeostasis

Current Diabetes Reviews, 2005
Genetic and environmental determinants play critical roles in insulin resistance and beta-cell function. A model of the complex feedback system for maintenance of glucose tolerance has been developed that reflects the constraint of glycemia within narrow physiologic limits.
Stephen S, Rich, Richard N, Bergman
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GPR55 and the regulation of glucose homeostasis

The International Journal of Biochemistry & Cell Biology, 2017
Pathophysiological conditions such as obesity and type 2 diabetes (T2D) are reportedly associated to over-activation of the endocannabinoid system (ECS). Therefore, modulation of the ECS offers potential therapeutic benefits on those diseases. GPR55, the receptor for L-α-lysophosphatidylinositol (LPI) that has also affinity for various cannabinoid ...
Eva, Tudurí   +4 more
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