Results 111 to 120 of about 171,724 (348)

Aging-associated Alteration in the Cardiac MIF-AMPK Cascade in Response to Ischemic Stress [PDF]

, 2008
An important role for a macrophage migration inhibitory factor (MIF)-AMP-activated protein kinase (AMPK) signaling pathway in ameliorating myocardial damage following ischemia/reperfusion has been described. An aging-associated reduction in AMPK activity
Erin Lane, Heng Ma, Ji Li, Jingying Wang, Jun Ren, Lin Leng, Richard Bucala, Wenkui Wang   +7 more
core   +1 more source

Intersection between metabolic dysfunction, high fat diet consumption, and brain aging [PDF]

, 2010
Deleterious neurochemical, structural, and behavioral alterations are a seemingly unavoidable aspect of brain aging. However, the basis for these alterations, as well as the basis for the tremendous variability in regards to the degree to which these ...
Adami, Adams, Adelman, Aguero-Torres, Ahima, Ahren, Akomolafe, Antuna-Puente, Arribas, Arvanitakis, Arvanitakis, Astrup, Bannon, Baran, Barber, Bartus, Barzilai, Baumbach, Baumbach, Baumbach, Behrendt, Bellinger, Berlett, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bertoni-Freddari, Bjorntorp, Blander, Boden, Bolton, Bordone, Bordone, Brandes, Braun, Bravo, Broughton, Bruce-Keller, Buettner, Bugalho, Bullo, Cai, Calabrese, Calabrese, Calabrese, Calabrese, Calabrese, Carlsson, Carr, Cecarini, Cefalu, Cefalu, Chen, Chen, Chen, Clark, Clayton, Clayton, Comfort, Coon, Coyle, Coyle, Craft, Craft, Curb, Damjanovic, De Feo, de la Torre, Dechenes, DeFronzo, DeFronzo, DeKosky, Desai, Ding, Diniz, Droge, Dunn, d’Alessio, Eckles-Smith, Elahi, Elias, Elias, Elias, Fagot-Campagna, Fantuzzi, Farr, Fassbender, Ferrannini, Ferrannini, Ferrannini, Festa, Finch, Finkel, Franceschi, Freund, Fridlyand, Friedman, Frohman, Frolich, Fruhbeck, Fujimoto, Furukawa, Gabbita, Gabriely, Gazzaley, Gemma, Gibson, Gibson, Giunta, Gold, Gonzalez, Good, Granholm, Gray, Greenwood, Griffin, Gunning-Dixon, Gupta, Guttmann, Haan, Handschin, Harvey, Haslam, Heistad, Heitner, Ho, Hosokawa, Howard, Hoyer, Hsu, Hu, Hultsch, Hynd, Iqbal, Itateyama, Iyo, Izumi, James, Jankowsky, Janson, Jia, Joseph, Juhan-Vague, Kaasinen, Kanoski, Kennedy, Kirwan, Kissebah, Kitani, Klann, Klann, Knapp, Koenig, Kuk, Kumar, Kumari, Kuo, Kuriyama, Kuriyama, Laakso, Lamarche, Langan, Lau, Launer, Lee, Leibson, Leone, Lesser, Li, Lippa, Luchsinger, MacKnight, Magnusson, Maier, Manev, Mantena, Massaad, Matia, Matsuzawa-Nagata, Mattson, Mattson, Mattson, Mattson, McClearn, McNay, McNay, Medawar, Mendall, Meng, Messier, Michikawa, Miller, Miller, Milne, Moller, Moreira, Morin, Morrison, Muckle, Nag, Nagai, Navarro, Newton, Nielsen, Nisoli, Nunomura, Nyberg, Oakes, Ogawa, Oomura, Osmond, Ott, O’Shaughnessy, Pacini, Paolisso, Park, Partridge, Pasinetti, Pasinetti, Patterson, Pedigo, Peila, Peiris, Perlmuter, Perry, Perry, Petrovitch, Pfluger, Picard, Pinteaux, Pistell, Qiu, Qu, Rasouli, Razay, Rinne, Rizza, Rizza, Robertson-Tchabo, Roher, Roman, Rosamond, Rowe, Sattler, Sayre, Scacchi, Scheff, Schmitt-Schillig, Shen, Shi, Shimokata, Smith, Smith, Smith, Sohal, Sonntag, Souza, Spulber, Stadtman, Stadtman, Steemburgo, Steen, Strauss, Svedberg, Tanner, Tariot, Taylor, Terao, Terao, Terry, Tha, Thiels, Thiels, Tohgi, Tschop, Urakawa, Uz, van der Heide, van Exel, Vannucchi, Volkow, Wahrenberg, Wang, Wang, Wang, Ward, Wenk, White, Wieringa, Williams, Winocur, Wong, Woods, Wu, Wu, Xiao, Yaffe, Yasui, Ye, Yudkin, Zhang, Zhao, Zlokovic   +302 more
core   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

SAT045 Sexually Dimorphic Effects Of CCN5/WISP2 Overexpression On HFD-STZ Induced Diabetes And Glucose Intolerance

, 2023
Tara Alami, Mahvash Zakikhani, Viktoria Xega, Jun‐Li Liu   +3 more
openalex   +1 more source

A worldwide correlation of lactase persistence phenotype and genotypes [PDF]

, 2010
Background: The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research.
Ingram, C.J.E., Itan, Y., Jones, B.L., Swallow, D.M., Thomas, M.G.   +4 more
core   +3 more sources

Comparison of the effectiveness, safety and tolerability of Perampanel and Levetiracetam as monotherapy in Chinese patients with focal‐onset seizures: A single‐center, ambispective, open‐label, real‐world observational study

Epilepsia Open, EarlyView.
Abstract Objective To compare the effectiveness and safety of Perampanel (PER) and Levetiracetam (LEV) as monotherapy in Chinese patients with focal‐onset seizures (FOS). Methods This is a single‐center, ambispective, open‐label, real‐world observational study.
Haiyan Ma, Rui Zhang, Yan Zhang, Honghao Xu, Xuefeng Qu, Yiqing Yang, Jiajia Li, Lu Yang, Qigang Zhou, Haitao Zhu   +9 more
wiley   +1 more source

Current trends in the management of childhood gastroenteritis in the community [PDF]

, 1989
Infection of the gastrointestinal tract are still amongst the most common infections of childhood. Despite improvements in the standard of living over the last fifty years, gastroenteritis still constitutes a sizeable amount of general practitioner ...
Vella, Cecil
core  

High-protein-low-carbohydrate diet: deleterious metabolic and cardiovascular effects depend on age [PDF]

, 2014
High-protein-low-carbohydrate (HP-LC) diets have become widespread. Yet their deleterious consequences, especially on glucose metabolism and arteries, have already been underlined.
A. Ayer, C. Marchiol-Fournigault, C.H. Cottart, D. Henrion, E. Vessieres, F. Noble, F. Vibert, J.L. Beaudeux, J.L. Golmard, J.L. Paul, S. Baron, T. Bedarida, V. Nivet-Antoine   +12 more
core   +3 more sources

Bioengineered Isoflavone–Probiotic Functional Foods for Sustainable Modulation of Metabolic and Reproductive Health in PCOS

Food Bioengineering, EarlyView.
Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi, Panneerselvam Sneha, Dhanapal Saravanan Mridula, Keerthivasan Nimithasree, Valliappan Sanjay   +4 more
wiley   +1 more source

The Usefulness of Homeostatic Measurement Assessment-Insulin Resistance (HOMA-IR) for Detection of Glucose Intolerance in Thai Women of Reproductive Age with Polycystic Ovary Syndrome

International Journal of Endocrinology, 2012
Objectives. To study the cut-off point of Homeostatic Measurement Assessment-Insulin Resistance (HOMA-IR) as a screening test for detection of glucose intolerance in Thai women with polycystic ovary syndrome (PCOS). Study Design.
Thanyarat Wongwananuruk, Manee Rattanachaiyanont, Pichai Leerasiri, Suchada Indhavivadhana, Kitirat Techatraisak, Surasak Angsuwathana, Prasong Tanmahasamut, Chongdee Dangrat   +7 more
doaj   +1 more source