Results 141 to 150 of about 111,943 (300)

Blubber Thickening Driven by UCP1 Inactivation: Insights from a Cetacean‐Like Transgenic Mouse Model

Integrative Zoology, EarlyView.
UCP1 inactivation of cetaceans in mice drives BAT whitening and iWAT hyperplasia, promoting fat accumulation for aquatic adaptation. Abstract Cetaceans possess thick blubber, a specialized adipose tissue essential for thermal insulation, a streamlined body form, energy storage, and buoyancy. However, the mechanisms that underpin this adaptation are not
Qian Zhang, Yuehua Wang, Hang Zhang, Guiping Xu, Shixia Xu, Guang Yang   +5 more
wiley   +1 more source

Content validation of the nursing diagnosis “Adult Disuse Syndrome”: A quantitative study

International Journal of Nursing Knowledge, EarlyView.
Abstract Purpose This study aimed to establish the content validity of the proposed nursing diagnosis (ND) “Adult Disuse Syndrome” and all its components. Method This is an exploratory descriptive study of diagnostic content validation under Fehring's proposal.
Edinson Fabian Ardila‐Suárez, Vanessa Sánchez‐Martínez, Paula Escalada‐Hernández   +2 more
wiley   +1 more source

Cardiometabolic Treatment Gap in Routine Psychiatric Care: A Cross‐Sectional Study of 1553 Patients

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background People with severe mental illness (SMI) have elevated cardiometabolic morbidity and mortality, with similar concerns increasingly reported in other psychiatric conditions including anxiety disorders and ADHD. Somatic conditions are often underdiagnosed and pharmacologically undermanaged in this population.
Vincent Achour, Melanie Faugere, Laurent Boyer, Christophe Lançon, Theo Korchia   +4 more
wiley   +1 more source

Early‐ vs. late‐onset gestational diabetes: Differential impact on maternal and neonatal outcomes

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Early‐onset gestational diabetes mellitus (diagnosed before 20 weeks) identifies a clinically higher‐risk phenotype than late‐onset GDM (24–28 weeks), with greater insulin requirement and higher adjusted risks of preeclampsia, cesarean delivery, preterm birth, and adverse neonatal outcomes.
Baolai Li, Wenjun Ji, Rui Zhao, Jinchun Zhang   +3 more
wiley   +1 more source

Glucagon‐like peptide‐1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions

British Journal of Pharmacology, EarlyView.
Abstract Gastric inhibitory polypeptide (GIP)/Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are increasingly prescribed for the management of obesity and type 2 diabetes, yet research pertinent to their effects on muscle health is limited. Considering the central role of muscle strength as a sarcopenia component, this article summarizes emerging ...
Konstantinos Prokopidis
wiley   +1 more source

Impact of Elovl3 Suppression on Sleep Deprivation-Induced Hepatic Steatosis and Glucose Intolerance in Mice. [PDF]

Cureus
Shigiyama F, Tanaka S, Okayama C, Kumashiro N.   +3 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Therapeutic potential of dihydronicotinamide riboside (NRH) on obesity and glucose intolerance in mice. [PDF]

Nat Commun
Rumpler M, van Mierlo G, Vinten KT, Giner MP, Christen S, Hayat F, Makarov MV, Gardeux V, Russeil J, Schomakers BV, van Gijn L, Hashimi H, Steiner C, Giroud-Gerbetant J, Joffraud M, Sanchez Garcia JL, Moco S, Migaud ME, Houtkooper RH, Deplancke B, Canto C.   +20 more
europepmc   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Prenatal Glucose Intolerance and Child Neurodevelopmental Disorders. [PDF]

JAMA Netw Open
Grosvenor LP, Gunderson EP, Qian Y, Alexeeff S, Ames JL, Weiss LA, Sahagun E, Ashwood P, Yolken R, Zhu Y, Van de Water J, Croen LA.   +11 more
europepmc   +1 more source