Results 191 to 200 of about 778,750 (285)

Association of GLP‐1 Receptor Agonists With Gastrointestinal and Liver Outcomes in Adults With Type 2 Diabetes: A Target Trial Emulation Study

Diabetes, Obesity and Metabolism, EarlyView.
Dazheng Zhang, Ying Lu, Xinyao Jian, Haoyuan Wang, Jacquelyn Hatch‐Stein, Ronen Stein, Jennifer Panganiban, Yong Chen   +7 more
wiley   +1 more source

Frailty and low body mass index as key determinants of sodium‐glucose cotransporter 2 inhibitor‐specific adverse event‐related discontinuation in adults aged ≥75 years: A multicenter real‐world retrospective cohort study

Journal of Diabetes Investigation, EarlyView.
Among Japanese adults aged ≥75 years newly initiating SGLT2 inhibitors, SGLT2 inhibitor–specific adverse event‐related discontinuation occurred in 9.1% within 180 days. Frailty and low BMI, rather than chronological age, were the key predictors, highlighting the importance of assessing physiological reserve before treatment initiation.
Taisuke Uchida, Hiroaki Ueno, Ayaka Konagata, Hiroki Nabekura, Yuki Kikuchi, Takumi Beppu, Akari Sekishima, Hirotaka Sekishima, Takayuki Nakamura, Fumiko Kogo, Yudai Uehira, Yuri Tanaka, Hideki Yamaguchi, Kazuya Shimoda   +13 more
wiley   +1 more source

Circulating 1,5-anhydroglucitol levels combined with pre-pregnancy BMI is a simple predictive marker of future glucose intolerance in women with gestational diabetes. [PDF]

J Endocrinol Invest
Quansah DY, Jiménez-Sánchez C, Maechler P, Puder JJ.   +3 more
europepmc   +1 more source

Influence of age on the development of stress hyperglycemia during first‐onset ST‐elevation myocardial infarction

Journal of Diabetes Investigation, EarlyView.
Among 8,779 non‐diabetic patients with first‐onset STEMI, older age was associated with a higher likelihood of stress hyperglycemia. However, the excess mortality risk associated with stress hyperglycemia was greatest in younger patients and attenuated with advancing age, highlighting the possibility of age‐dependent prognostic significance.
Hon Jen Wong, Joy Xin Yi Au, Yao Hao Teo, Yao Neng Teo, Chen Ee Low, Chun En Yau, Norman H.Y. Lin, Pei Chia Eng, Li Feng Tan, Reshma A. Merchant, Ping Chai, Anand Adinath Ambhore, James W. L. Yip, Andrew Fu‐Wah Ho, David Foo, Pow‐Li Chia, Patrick Zhan‐Yun Lim, Khung Keong Yeo, Weien Chow, Daniel Thuan Tee Chong, Derek J. Hausenloy, Mark Y. Y. Chan, Ching‐Hui Sia   +22 more
wiley   +1 more source

Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response. [PDF]

Int J Oral Sci
Lê S, Sturaro E, Thomas C, Canceill T, Ekambi B, Fellouah N, Knauf C, Abot A, Tenailleau C, Duployer B, Loubieres P, Prosper A, Diemer S, Burcelin R, Diemer F, Minty M, Blasco-Baque V.   +16 more
europepmc   +1 more source

Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End‐of‐Life Palliative Care

Journal of Evidence-Based Medicine, EarlyView.
ABSTRACT Older patients receiving end‐of‐life palliative care often present with multiple geriatric syndromes, frailty, and comorbid symptom burden, resulting in a high risk of medication‐related harm. This guideline focuses on pharmacological management of distressing symptoms in older patients receiving end‐of‐life or hospice‐oriented palliative care,
Daiping Li, Yanwu Yang, Yan Zhang, Jirong Yue, Birong Dong, Meiling Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University   +7 more
wiley   +1 more source

Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone. [PDF]

Bone Res
Valle-Tenney R, Peredo N, De Samblancx K, Nefyodova E, Cardoen R, Dehaemers T, Farlay D, Chapurlat R, Van der Schueren B, Mathieu C, Vangoitsenhoven R, Maes C.   +11 more
europepmc   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source

Pancreatic α-cell sodium-glucose cotransporter 1 (SGLT1) does not appear to contribute to hyperglucagonemia and glucose intolerance in diabetic mice. [PDF]

Endocr J
Ikeuchi Y, Kikuchi O, Kobayashi M, Tabei Y, Hashimoto H, Kobayashi R, Horii T, Hatada I, Miyatsuka T, Kitamura T.   +9 more
europepmc   +1 more source

The Oral‐Hepatic Axis: Epidemiological and Mechanistic Links Between Periodontal and Liver Diseases

Journal of Periodontal Research, EarlyView.
This review summarizes current epidemiological, clinical and mechanistic evidence linking periodontitis and chronic liver diseases, highlighting the oral‐gut‐liver axis, shared immunometabolic and nutritional pathways and opportunities for integrated preventive and therapeutic strategies.
Sinem Esra Sahingur, Kinga Grzech‐Leśniak, Samuel F. Suslavich, Janina Golob Deeb   +3 more
wiley   +1 more source