Results 191 to 200 of about 111,943 (300)

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response. [PDF]

Int J Oral Sci
Lê S, Sturaro E, Thomas C, Canceill T, Ekambi B, Fellouah N, Knauf C, Abot A, Tenailleau C, Duployer B, Loubieres P, Prosper A, Diemer S, Burcelin R, Diemer F, Minty M, Blasco-Baque V.   +16 more
europepmc   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone. [PDF]

Bone Res
Valle-Tenney R, Peredo N, De Samblancx K, Nefyodova E, Cardoen R, Dehaemers T, Farlay D, Chapurlat R, Van der Schueren B, Mathieu C, Vangoitsenhoven R, Maes C.   +11 more
europepmc   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Pancreatic α-cell sodium-glucose cotransporter 1 (SGLT1) does not appear to contribute to hyperglucagonemia and glucose intolerance in diabetic mice. [PDF]

Endocr J
Ikeuchi Y, Kikuchi O, Kobayashi M, Tabei Y, Hashimoto H, Kobayashi R, Horii T, Hatada I, Miyatsuka T, Kitamura T.   +9 more
europepmc   +1 more source

Blocking protein quality control degradation leads to structural stabilization of DHFR indel variants

The FEBS Journal, EarlyView.
Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet, Caroline H. Suhr, Sarah Gersing, Celeste M. Hackney, Amelie Stein, Kaare Teilum, Rasmus Hartmann‐Petersen   +6 more
wiley   +1 more source

A long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin secretion in mice. [PDF]

Sci Adv
Gallop MR, Vieira RFL, Mower PD, Matsuzaki ET, Liou W, Smart FE, Roberts S, Evason KJ, Holland WL, Chaix A.   +9 more
europepmc   +1 more source

Functional Outcomes of Prosthetic Rehabilitation in Older Adults With Tooth Loss: A Systematic Review and Meta‐Analysis

Gerodontology, EarlyView.
ABSTRACT Objectives To assess the effect of prosthodontic treatment and management on oral function and oral‐health‐related patient reported outcome measures (PROMs) in older adults with tooth loss. Methods A systematic search of four databases identified clinical studies (≥ 10 participants) reporting functional or PROM outcomes in partially or fully ...
Pedro Molinero‐Mourelle, Azize Bell, Najla Chebib, Manabu Kanazawa, Frauke Müller, Annika Neri, Takahiro Ono, Masako Shiramizu, Sayaka Tada   +8 more
wiley   +1 more source

Increased TGF-β/Activin-Smad2 signaling is associated with pancreatic β-cell dysfunction and glucose intolerance in gestational diabetes mellitus. [PDF]

Mol Metab
Boronat-Belda T, Ferrero H, Soriano S, Ribes-García E, Betoret-Gustems R, Martínez-Bañón D, Serrano-Selva M, Martínez-Pinna J, Nadal Á, Quesada I, Alonso-Magdalena P.   +10 more
europepmc   +1 more source