Results 171 to 180 of about 778,750 (285)

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Association between glucose intolerance and psoriatic arthritis features. [PDF]

RMD Open
Mehta S, Yang M, Dimitropoulos L, Thib S, Koppikar S, Cook RJ, Eder L.   +6 more
europepmc   +1 more source

Adipocyte‐specific NIK depletion enhances energy metabolism and glucose tolerance in mice

The FEBS Journal, EarlyView.
Obesity is associated with reduced energy expenditure and increased hepatic lipid accumulation. This study reveals that loss of NIK in adipocytes stimulates FGF21‐driven expression of thermogenic genes, including UCP1, and mitochondrial uncoupled respiration.
Atakan Ozcan, Caroline Uslucan, Aleyna Kizilyer, Samet Agca, Aylin Karatas, Sanaz Naghizadeh, Bahar Zehra Camurdanoglu Weber, Sukru Anil Dogan, Serkan Kir   +8 more
wiley   +1 more source

Prenatal Glucose Intolerance and Child Neurodevelopmental Disorders.

JAMA Netw Open
Grosvenor LP, Gunderson EP, Qian Y, Alexeeff S, Ames JL, Weiss LA, Sahagun E, Ashwood P, Yolken R, Zhu Y, Van de Water J, Croen LA.   +11 more
europepmc   +1 more source

Maternal Programming with a Cafeteria Diet Leads to Glucose Intolerance, Increased Insulinemia, Inflammation, and Intestinal Dysbiosis in Rat Offspring. [PDF]

Prev Nutr Food Sci
Correia Gomes D, Zamora-Briseño JA, Camacho Morales A, Cárdenas Tueme M, Sarmiento CC, Zepeda RC, Viveros Contreras R.   +6 more
europepmc   +1 more source

Blocking protein quality control degradation leads to structural stabilization of DHFR indel variants

The FEBS Journal, EarlyView.
Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet, Caroline H. Suhr, Sarah Gersing, Celeste M. Hackney, Amelie Stein, Kaare Teilum, Rasmus Hartmann‐Petersen   +6 more
wiley   +1 more source

Early-life thymectomy results in visceral adipose tissue inflammation and glucose intolerance. [PDF]

Immun Ageing
Buckley DJ, Zahedi S, Velusamy P, Sharma S, Sabnani M, Flores LC, Tandukar G, Ikeno Y, Fadel PJ, Lesniewski LA, Trott DW.   +10 more
europepmc   +1 more source

Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Hemodialysis International, EarlyView.
ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha, Richard Shamoon, Ameer Almeshagbeh, Samah Masry, Fadel Alqatati, Baha H. Abuajameia, Abdulqadir J. Nashwan   +6 more
wiley   +1 more source

Tryptophan and polyamine metabolism dysregulation serves as an early marker of high-fat diet-induced glucose intolerance. [PDF]

J Lipid Res
Gao J, Zhang L, Zhan S, Peng Z, Du J, Zhang Z, Xu L, Huang S, Wang X, Guo X.   +9 more
europepmc   +1 more source

Lignan‐rich Norway spruce (Picea abies) resin extract exhibits anti‐inflammatory, skin‐regenerative and anti‐acne effects: In vitro, in silico, biocompatibility and exploratory clinical findings

International Journal of Cosmetic Science, EarlyView.
GA text A 30% Picea abies resin extract cream combined antimicrobial, anti‐inflammatory and early pro‐repair activities relevant to acne‐prone skin. The formulation showed strong activity against Cutibacterium acnes, reduced inflammatory cytokines and demonstrated promising tolerability and efficacy in an exploratory in‐use study. Abstract Objective To
Simone Parrotta, Kamilla Yamileva, Laura Punakallio, Maryam Ghanbarirad, Evgen Multia   +4 more
wiley   +1 more source