Results 121 to 130 of about 276,644 (306)

Oral glucose tolerance test in unstimulated saliva of healthy individuals [PDF]

open access: yes, 2016
Objective: The aim of this study was to investigate oral glucose tolerance test (OGTT) in unstimulated whole saliva as a diagnostic specimen in clinical practice for detection of diabetes mellitus (DM).
Mirzaii-Dizgah, I.   +2 more
core  

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng   +14 more
wiley   +1 more source

The role of biological rhythms and blood glucose levels in maintaining a positive mood state. [PDF]

open access: yes, 2008
A thesis submitted in partial fulfilment of the requirements of the University of Wolverhampton for the degree of Doctor of PhilosophyAlthough the effects of both the menstrual and circadian cycles on mood have been well documented, the question of ...
Martino, Orsolina I.
core  

Rebreathing‐induced hypoxemia improves glucose tolerance in adults with type 2 diabetes

open access: yesPhysiological Reports
Hypoxia stimulates glucose uptake in isolated skeletal muscle through an insulin‐independent pathway. Intermittent hypoxia can lower glucose concentration in adults with type 2 diabetes, but its application remains limited by the use of gas tanks to ...
Jiahui Zhao   +2 more
doaj   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

open access: yesAdvanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu   +8 more
wiley   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

open access: yesAdvanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai   +7 more
wiley   +1 more source

The Impact of glucose and glucoregulation on memory [PDF]

open access: yes
The effect of glucose on memory has been investigated for in excess of 25 years, with some consensus generated amongst the literature indicating that glucose has a facilitating effect.
Elliott, Jade
core  

Anthropometry, glucose tolerance and insulin concentrations in South Indian children: relationships to maternal glucose tolerance during pregnancy [PDF]

open access: yes, 2005
Earlier studies have shown that individuals whose mothers were diabetic when they were in utero, have an increased risk of early obesity, and impaired glucose tolerance (lGT) and type 2 diabetes in adult life.
Krishnaveni, Ghattu Vedamurthy
core  

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

open access: yesAdvanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao   +11 more
wiley   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

open access: yesAdvanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao   +11 more
wiley   +1 more source

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