Results 21 to 30 of about 4,524 (166)

Role of positive glucose challenge test only versus oral glucose tolerance test in pregnancy outcome: a comparative study

Journal of Pathology of Nepal, 2019
Background: Gestational diabetes mellitus is defined as any degree of glucose intolerance which is first recognized during pregnancy and is associated with a number of adverse perinatal outcomes, such as neonatal hypoglycemia, macrosomia with an ...
Neha Homagai, Nirajan Mainali, Sikha Rijal   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Prolonged plasma glucose elevation on oral glucose tolerance test in young healthy Japanese individuals

Endocrinology, Diabetes & Metabolism, 2020
Aims This study aims to assess insulin secretion and resistance through oral glucose tolerance test (OGTT) among young Japanese individuals. Subjects and methods We enrolled 595 young healthy Japanese individuals aged 22‐29 years. They underwent an OGTT,
Hirotaka Ishigaki, Akihiro Yoshida, Osamu Araki, Takao Kimura, Katsuhiko Tsunekawa, Yoshifumi Shoho, Makoto Nara, Tomoyuki Aoki, Takayuki Ogiwara, Masami Murakami   +9 more
doaj   +1 more source

Antihyperglycemic effects of Lysiphyllum strychnifolium leaf extract in vitro and in vivo

Pharmaceutical Biology, 2023
Context Lysiphyllum strychnifolium (Craib) A. Schmitz (LS) (Fabaceae) has traditionally been used to treat diabetes mellitus.Objective This study demonstrates the antidiabetic and antioxidant effects of aqueous extract of LS leaves in vivo and in vitro ...
Arman Syah Goli, Vilasinee Hirunpanich Sato, Hitoshi Sato, Savita Chewchinda, Jiraporn Leanpolchareanchai, Jannarin Nontakham, Jantana Yahuafai, Thavaree Thilavech, Pongsatorn Meesawatsom, Metawee Maitree   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Uptake of Screening for Type 2 Diabetes and Prediabetes by Means of Glycated Hemoglobin versus the Oral Glucose Tolerance Test among 18 to 60-Year-Old People of South Asian Origin: A Comparative Study.

PLoS ONE, 2015
BackgroundDirect comparisons of the effect of a glycated haemoglobin measurement or an oral glucose tolerance test on the uptake and yield of screening in people of South Asian origin have not been made. We evaluated this in 18 to 60-year-old South Asian
Irene G M van Valkengoed, Everlina M A Vlaar, Vera Nierkens, Barend J C Middelkoop, Karien Stronks   +4 more
doaj   +1 more source

To Evaluate the Effect of Edrophonium on Blood Glucose Levels in Euglycemic Albino Rats Through OGTT [PDF]

Journal of Clinical and Diagnostic Research, 2015
Objective: To evaluate the effect of Edrophonium on blood glucose levels in euglycemic albino rats through OGTT. Materials and Methods: Twelve Swiss albino rats weighing around 150-200 gms of either sex were randomly selected from the central animal ...
Siddamma Amoghimath, Suresha R N, Jayanthi M K, Shruthi S L, Vaibhavi PS, Satish A M, Pushpa V H, Kalabharathi H L   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Evaluation of patient satisfaction following oral glucose tolerance test

Northwestern Medical Journal
Aim: Diabetes mellitus (DM) is a common metabolic disease. Early diagnosis of diabetes prevents the increase in mortality and morbidity due to complications.
Püren Gökbulut, Habib Bilen, Emin Murat Akbaş, Çigdem Özdemir, Volkan Gökbulut, Gönül Koç   +5 more
doaj   +1 more source

Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes. [PDF]

PLoS ONE, 2009
BACKGROUND: The prevalence of overweight is increasing globally and has become a serious health problem. Low-grade chronic inflammation in overweight subjects is thought to play an important role in disease development.
Suzan Wopereis, Carina M Rubingh, Marjan J van Erk, Elwin R Verheij, Trinette van Vliet, Nicole H P Cnubben, Age K Smilde, Jan van der Greef, Ben van Ommen, Henk F J Hendriks   +9 more
doaj   +1 more source