Results 31 to 40 of about 84,281 (289)

Glucose represses connexin36 in insulin-secreting cells [PDF]

Journal of Cell Science, 2005
The gap-junction protein connexin36 (Cx36) contributes to control the functions of insulin-producing cells. In this study, we investigated whether the expression of Cx36 is regulated by glucose in insulin-producing cells. Glucose caused a significant reduction of Cx36 in insulin-secreting cell lines and freshly isolated pancreatic rat islets.
ALLAGNAT F, MARTIN D, CONDORELLI, Daniele Filippo, WAEBER G, HAEFLIGER JA   +4 more
openaire   +5 more sources

Hepatic p63 regulates glucose metabolism by repressing SIRT1

Gut, 2022
Objectivep63 is a transcription factor within the p53 protein family that has key roles in development, differentiation and prevention of senescence, but its metabolic actions remain largely unknown. Herein, we investigated the physiological role of p63 in glucose metabolism.DesignWe used cell lines and mouse models to genetically manipulate p63 in ...
Gonzalez-Rellan, Maria J, Novoa, Eva, da Silva Lima, Natalia, Rodriguez, Amaia, Veyrat-Durebex, Christelle, Seoane, Samuel, Porteiro, Begoña, Fondevila, Marcos F, Fernandez, Uxia, Varela-Rey, Marta, Senra, Ana, Iglesias, Cristina, Escudero, Adriana, Fidalgo, Miguel, Guallar, Diana, Perez-Fernandez, Roman, Prevot, Vincent, Schwaninger, Markus, López, Miguel, Dieguez, Carlos, Coppari, Roberto, Frühbeck, Gema, Nogueiras, Ruben   +22 more
openaire   +4 more sources

Role of Elm1, Tos3, and Sak1 Protein Kinases in the Maltose Metabolism of Baker’s Yeast

Frontiers in Microbiology, 2021
Glucose repression is a key regulatory system controlling the metabolism of non-glucose carbon source in yeast. Glucose represses the utilization of maltose, the most abundant fermentable sugar in lean dough and wort, thereby negatively affecting the ...
Xu Yang, Lu Meng, Xue Lin, Xue Lin, Xue Lin, Huan-Yuan Jiang, Xiao-Ping Hu, Xiao-Ping Hu, Xiao-Ping Hu, Cong-Fa Li, Cong-Fa Li, Cong-Fa Li   +11 more
doaj   +1 more source

Genotypic Variation in Ethanolic Fermentation Using New Genetically Recombinants of Saccharomyces cerevisiae [PDF]

Journal of Agricultural Chemistry and Biotechnology, 2020
This study aimed to investigate metabolic changed related to glucose – repression by the analysis of ethanol productivity which is mainly affected by the glucose effect. Five parental isolates and 15 genotypes derived from three crosses were used in this
Manar El. Baz, A. Abd El. Hadi, K. Zaied, Mervat Kamal   +3 more
doaj   +1 more source

Glucose Repression in Saccharomyces cerevisiae Is Related to the Glucose Concentration Rather Than the Glucose Flux [PDF]

Journal of Biological Chemistry, 1998
Glucose plays an important regulatory role in the yeast Saccharomyces cerevisiae, which is mostly reflected at the transcriptional level by glucose repression. The signal that initiates glucose repression is unknown, but data indicate that it is located at or above the level of glucose 6-phosphate, suggesting the involvement of either the intracellular
M M, Meijer, J, Boonstra, A J, Verkleij, C T, Verrips   +3 more
openaire   +2 more sources

Flux-Enabled Exploration of the Role of Sip1 in Galactose Yeast Metabolism

Frontiers in Bioengineering and Biotechnology, 2017
13C metabolic flux analysis (13C MFA) is an important systems biology technique that has been used to investigate microbial metabolism for decades. The heterotrimer Snf1 kinase complex plays a key role in the preference Saccharomyces cerevisiae exhibits ...
Christopher M. Shymansky, Christopher M. Shymansky, Christopher M. Shymansky, George Wang, George Wang, Edward E. K. Baidoo, Edward E. K. Baidoo, Jennifer Gin, Jennifer Gin, Amanda Reider Apel, Amanda Reider Apel, Aindrila Mukhopadhyay, Aindrila Mukhopadhyay, Héctor García Martín, Héctor García Martín, Héctor García Martín, Héctor García Martín, Jay D. Keasling, Jay D. Keasling, Jay D. Keasling, Jay D. Keasling, Jay D. Keasling   +21 more
doaj   +1 more source

Hexokinase and Glucokinases Are Essential for Fitness and Virulence in the Pathogenic Yeast Candida albicans

Frontiers in Microbiology, 2019
The pathogenic yeast Candida albicans is both a powerful commensal and a pathogen of humans that can infect wide range of organs and body sites. Metabolic flexibility promotes infection and commensal colonization by this opportunistic pathogen.
Romain Laurian, Karine Dementhon, Bastien Doumèche, Alexandre Soulard, Thierry Noel, Marc Lemaire, Pascale Cotton   +6 more
doaj   +1 more source

Conventional and emerging roles of the energy sensor Snf1/AMPK in Saccharomyces cerevisiae

Microbial Cell, 2018
All proliferating cells need to match metabolism, growth and cell cycle progression with nutrient availability to guarantee cell viability in spite of a changing environment.
Paola Coccetti, Raffaele Nicastro, Farida Tripodi   +2 more
doaj   +1 more source

The Involvement of Mig1 from Xanthophyllomyces dendrorhous in Catabolic Repression: An Active Mechanism Contributing to the Regulation of Carotenoid Production. [PDF]

PLoS ONE, 2016
The red yeast X. dendrorhous is one of the few natural sources of astaxanthin, a carotenoid used in aquaculture for salmonid fish pigmentation and in the cosmetic and pharmaceutical industries for its antioxidant properties.
Jennifer Alcaíno, Natalia Bravo, Pamela Córdova, Andrés E Marcoleta, Gabriela Contreras, Salvador Barahona, Dionisia Sepúlveda, María Fernández-Lobato, Marcelo Baeza, Víctor Cifuentes   +9 more
doaj   +1 more source

Glucose repression in the yeast Saccharomyces cerevisiae [PDF]

Molecular Microbiology, 1992
SummaryUnderstanding the mechanism of glucose repression in yeast has proved to be a difficult and challenging problem. A multitude of genes in different pathways are repressed by glucose at the level of transcription. The SUC2 gene, which encodes invertase, is an excellent reporter gene for glucose repression, since its expression is controlled ...
openaire   +2 more sources