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Facilitative glucose transporters [PDF]

European Journal of Biochemistry, 1994
Facilitative glucose transport is mediated by members of the Glut protein family that belong to a much larger superfamily of 12 transmembrane segment transporters. Six members of the Glut family have been described thus far. These proteins are expressed in a tissue‐ and cell‐specific manner and exhibit distinct kinetic and regulatory properties that ...
Mike Mueckler
openalex   +5 more sources

Structure and mechanism of a phosphotransferase system glucose transporter [PDF]

Nature Communications
Glucose is the primary source of energy for many organisms and is efficiently taken up by bacteria through a dedicated transport system that exhibits high specificity.
Patrick Roth, Jean-Marc Jeckelmann, Inken Fender, Zöhre Ucurum, Thomas Lemmin, Dimitrios Fotiadis   +5 more
doaj   +2 more sources

Osteopontin upregulates the expression of glucose transporters in osteosarcoma cells. [PDF]

PLoS ONE, 2014
Osteosarcoma is the most common primary malignancy of bone. Even after the traditional standard surgical therapy, metastasis still occurs in a high percentage of patients.
I-Shan Hsieh, Rong-Sen Yang, Wen-Mei Fu
doaj   +1 more source

Glucose Transport and Transporters in the Endomembranes [PDF]

International Journal of Molecular Sciences, 2019
Glucose is a basic nutrient in most of the creatures; its transport through biological membranes is an absolute requirement of life. This role is fulfilled by glucose transporters, mediating the transport of glucose by facilitated diffusion or by secondary active transport.
Beáta Lizák, András Szarka, Yejin Kim, Kyu-sung Choi, Csilla E. Németh, Paola Marcolongo, Angelo Benedetti, Gábor Bánhegyi, Éva Margittai   +8 more
openaire   +5 more sources

Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes [PDF]

, 2012
Increased renal clearance of thiamine (vitamin B1) occurs in experimental and clinical diabetes producing thiamine insufficiency mediated by impaired tubular re-uptake and linked to the development of diabetic nephropathy.
A Adaikalakoteswari, A AntonySunil, A Makino, A Turano, Anindita Das, AO Phillips, B Ashokkumar, B Dutta, B Sihag, BR Chamberlain, CME Tallaksen, Daniel Zehnder, ED Schleicher, Fang Zhang, G Gastaldi, GLJ Page, Guerman Molostvov, H Lum, H Smithline, HM Said, I Hubatsch, J Rieck, James R. Larkin, JC Reidling, JC Reidling, JC Reidling, JD Eudy, KA Robinson, Lisa Godfrey, MJ Boulware, MJ Ryan, MW Pfaffl, N Rabbani, N Rabbani, N Takahashi, N Tasevska, Naila Rabbani, Paul J. Thornalley, PJ Thornalley, R Babaei-Jadidi, S Sander, SM Nabokina, VS Subramanian   +42 more
core   +7 more sources

The GLUT4 Glucose Transporter [PDF]

Cell Metabolism, 2007
Few physiological parameters are more tightly and acutely regulated in humans than blood glucose concentration. The major cellular mechanism that diminishes blood glucose when carbohydrates are ingested is insulin-stimulated glucose transport into skeletal muscle.
Michael P. Czech, Shaohui Huang
openaire   +3 more sources

Assessing glucose uptake through the yeast hexose transporter 1 (Hxt1). [PDF]

PLoS ONE, 2015
The transport of glucose across the plasma membrane is mediated by members of the glucose transporter family. In this study, we investigated glucose uptake through the yeast hexose transporter 1 (Hxt1) by measuring incorporation of 2-NBDG, a non ...
Adhiraj Roy, Angela D Dement, Kyu Hong Cho, Jeong-Ho Kim   +3 more
doaj   +1 more source

Glucose Metabolism and Glucose Transporters in Breast Cancer [PDF]

Frontiers in Cell and Developmental Biology, 2021
Breast cancer is the most common malignancy in women worldwide and is associated with high mortality rates despite the continuously advancing treatment strategies. Glucose is essential for cancer cell metabolism owing to the Warburg effect. During the process of glucose metabolism, various glycolytic metabolites, such as serine and glycine metabolites,
Ja Seung Koo, Eunah Shin
openaire   +5 more sources

The Mammalian Glucose Transporters [PDF]

Pediatric Research, 1992
We have described the properties of glucose transporters expressed in several mammalian tissues and have summarized some of the adaptations that take place involving these molecules in various normal and abnormal states. With the exception of a few cell types, such as adipocytes and skeletal muscle, glucose transport is not a rate-limiting step in ...
Mike Mueckler, Sherin U. Devaskar
openaire   +3 more sources

Dysregulation of Glucose Homeostasis Following Chronic Exogenous Administration of Leptin in Healthy Sprague-Dawley Rats [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: Impaired glucose utilization is seen in chronic hyperleptinaemia associated conditions such as obesity and type 2 diabetes mellitus. It is unclear if this impaired glucose utilization is due to the effect of persistent hyperleptinaemia on
Khalil Wjidan, Effendi Ibrahim, Brinnell Caszo, Justin Gnanou, Harbindarjeet Singh   +4 more
doaj   +1 more source