Results 91 to 100 of about 365,436 (354)

Totality of evidence in trials of sodium–glucose co-transporter-2 inhibitors in the patients with heart failure with reduced ejection fraction: implications for clinical practice [PDF]

, 2020
Javed Butler, Faı̈ez Zannad, Gerasimos Filippatos, Stefan D. Anker, Milton Packer   +4 more
openalex   +1 more source

Effect of sodium-glucose transporter 2 inhibitors on bone [PDF]

, 2023
Mahdi Baradaranfard, Taha Ameli
openalex   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Diversity, expression, and structural modeling of sugar transporters in Anisakis simplex s. s. L3 and L4 larvae: an in vitro and in silico study

Frontiers in Cellular and Infection Microbiology
IntroductionGlucose transporter (GLUT) research in parasitic nematodes focuses on identifying and characterizing developmentally regulated isoforms, elucidating their regulatory and structural properties, and evaluating their potential as drug targets ...
Iwona Polak, Robert Stryiński, Łukasz Paukszto, Jan Paweł Jastrzębski, Iwona Bogacka, Elżbieta Łopieńska-Biernat   +5 more
doaj   +1 more source

Metformin use in pregnancy: promises and uncertainties [PDF]

, 2017
Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies.
Lindsay, Robert S., Loeken, Mary R.
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa

Malaria Journal, 2011
Glucose is the primary source of energy and a key substrate for most cells. Inhibition of cellular glucose uptake (the first step in its utilization) has, therefore, received attention as a potential therapeutic strategy to treat various unrelated ...
Derbyshire Elvira T, Krishna Sanjeev, Slavic Ksenija, Staines Henry M   +3 more
doaj   +1 more source

The insulin-like growth factor I receptor regulates glucose transport by astrocytes [PDF]

, 2016
Previous findings indicate that reducing brain insulin-like growth factor I receptor (IGF-IR) activity promotes ample neuroprotection. We now examined a possible action of IGF-IR on brain glucose transport to explain its wide protective activity, as ...
Allaman, Barnes, Barros, Barros, Biondi, Booth, Boucher, Bunn, C, Carro, Chuquet, Cohen, Cohen, Dringen, Dull, Fernandez, Fernandez, Gazit, Gontier, Gonzalez, Hamai, Jakoby, Kenyon, Koshy, Kum, Kuntner, L, La Joie, Ligensa, Liu, Loaiza, Lopez-Otin, M, Magalhaes Filho, Masters, Mathiisen, Matsunaga, Mergenthaler, Morgello, Muhic, Munive, Nimmerjahn, Nishijima, Perez-Alvarez, Pfaffl, Porras, Roy, Vilchez, Wieman, Winkler   +49 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

The neurological symptoms clinical diagnostics role in patients with genetic diseases

Сучасні медичні технології, 2019
The purpose of the study. The aim of the publication was to make analysis neurological symptoms peculiarities in patients with the glucose transporter type I deficiency syndrome and to make differential diagnostics with other diseases.
M. A. Trishchynskaya, V. A. Svystilnyk
doaj   +1 more source