Evolutionary dynamics of glucose-deprived cancer cells: insights from experimentally-informed mathematical modelling [PDF]
, 2023 Glucose is a primary energy source for cancer cells. Several lines of evidence support the idea that monocarboxylate transporters, such as MCT1, elicit metabolic reprogramming of cancer cells in glucose-poor environments, allowing them to reuse lactate, a byproduct of glucose metabolism, as an alternative energy source with serious consequences for ...
arxiv +1 more source
GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker
Clinics, 2011 OBJECTIVE: To analyze glucose transporter 1 expression patterns in malignant tumors of various cell types and evaluate their diagnostic value by immunohistochemistry.
Kátia C. Carvalho +9 more
doaj +1 more source
Tacrolimus Induces Insulin Resistance and Increases the Glucose Absorption in the Jejunum: A Potential Mechanism of the Diabetogenic Effects. [PDF]
PLoS ONE, 2015 The use of the immunosuppressive drug tacrolimus (TAC) is related to new onset diabetes after transplantation. Herein, we examined the effect of intraperitoneal administered TAC on intestinal glucose absorption in mice.Animals received low, medium, or ...
Zhiwei Li +9 more
doaj +1 more source
Multiparametric Cardiac 18F-FDG PET in Humans: Kinetic Model Selection and Identifiability Analysis [PDF]
IEEE Transactions on Radiation and Plasma Medical Sciences 2020, 2020 Cardiac 18F-FDG PET has been used in clinics to assess myocardial glucose metabolism. Its ability for imaging myocardial glucose transport, however, has rarely been exploited in clinics. Using the dynamic FDG-PET scans of ten patients with coronary artery disease, we investigate in this paper appropriate dynamic scan and kinetic modeling protocols for ...
arxiv +1 more source
Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality [PDF]
, 2010 A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and the use of a glucose analogue inhibitor permitted chemical validation of PfHT ...
Doerig, C +6 more
core +2 more sources
A Different SLC2A1 Gene Mutation in Glut 1 Deficiency Syndrome: c.734A>C
Balkan Medical Journal, 2017 Background: Glucose transporter type 1 deficiency syndrome is the result of impaired glucose transport into the brain. Patients with glucose transporter type 1 syndrome may present with infantile seizures, developmental delay, acquired microcephaly ...
Rüya Çolak +4 more
doaj +1 more source
PLoS ONE, 2021 The taste stimulus glucose comprises approximately half of the commercial sugar sweeteners used today, whether in the form of the di-saccharide sucrose (glucose-fructose) or half of high-fructose corn syrup (HFCS).
Paul A S Breslin +7 more
doaj +1 more source
Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders. [PDF]
, 2010 Neuronal glucose transporter (GLUT) isoform 3 deficiency in null heterozygous mice led to abnormal spatial learning and working memory but normal acquisition and retrieval during contextual conditioning, abnormal cognitive flexibility with intact gross ...
Devaskar, SU +8 more
core +2 more sources
Human Glucose Transporters in Renal Glucose Homeostasis [PDF]
International Journal of Molecular Sciences, 2021 The kidney plays an important role in glucose homeostasis by releasing glucose into the blood stream to prevent hypoglycemia. It is also responsible for the filtration and subsequent reabsorption or excretion of glucose. As glucose is hydrophilic and soluble in water, it is unable to pass through the lipid bilayer on its own; therefore, transport takes
Aleksandra Sędzikowska +1 more
openaire +2 more sources
Functional characterization of a hexose transporter from root endophyte Piriformospora indica
Frontiers in Microbiology, 2016 Understanding the mechanism of photosynthate transfer at symbiotic interface by fungal monosaccharide transporter is of substantial importance. The carbohydrate uptake at the apoplast by the fungus is facilitated by PiHXT5 hexose transporter in root ...
mamta Rani +5 more
doaj +1 more source