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Glucose Transport and Glucose Transporters in Muscle and Their Metabolic Regulation
Diabetes Care, 1990Skeletal muscle is the primary tissue responsible for insulin-dependent glucose uptake in vivo; therefore, glucose uptake by this tissue plays an important role in determining glycemia. Glucose uptake in muscle occurs by a system of facilitated diffusion involving at least two distinct glucose transporters, GLUT-1 and GLUT-4.
Amira Klip, Michel R Pâquet
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Disorders of Glucose Transport [PDF]
, 2006 To date, four congenital defects of monosaccharide transport are known (Fig. 11.1). Their clinical picture depends on tissue-specific expression and substrate specificity of the affected transporter. SGLT1 deficiency causes intestinal glucose-galactose malabsorption, a condition that presents with severe osmotic diarrhea and dehydration soon after ...
René Santer, Joerg Klepper
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Glucose Transporters in the Transepithelial Transport of Glucose
Journal of Electron Microscopy, 1996Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally-related substances across the cellular membranes. Two families of glucose transporter have been identified: the facilitated-diffusion glucose transporter family (GLUT family), and the NA(+)-dependent glucose transporter one (SGLT family).
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Erythroid glucose transporters
Current Opinion in Hematology, 2009Animals are heterotrophic and use sugar as their principal source of carbon. Every cell possesses at least one hexose transport system and of all cells, human erythrocytes express the highest level of the facilitative glucose transporter 1 (GLUT1). On the basis of human data, it was assumed that all mammalian erythrocytes express GLUT1 and that this ...
Naomi Taylor +2 more
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Trypanosome glucose transporters
Molecular and Biochemical Parasitology, 1998, by contrast adopts an intracellularenvironment within their mammalian hosts. Inva-sion and passage through different anatomicallocations within insect vectors also distinguishesthe parasites.All trypanosome species use glucose as a crucialsource of energy, and all have specific plasmamembrane transporters to facilitate the uptake ofthis molecule. Four
Théo Baltz +4 more
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Glucose Transporters in the Thyroid
Thyroid, 2005Glucose transport, mediated by proteins expressed from the glucose transporter genes, plays an essential role in cellular metabolism. Increased uptake of glucose compared to cells in normal tissue is a defining characteristic of malignant cells.
Orlo H. Clark +5 more
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Regulated transport of the glucose transporter GLUT4
Nature Reviews Molecular Cell Biology, 2002In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from an intracellular location to the cell surface, where it facilitates the reduction of plasma glucose levels. Understanding the molecular mechanisms that mediate this translocation event involves integrating our knowledge of two fundamental processes--the ...
Bryant, Nia J +2 more
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Glucose transport in the heart
Frontiers in Bioscience, 2004The heart is a unique organ in many ways. It consists of specialized muscle cells (cardiomyocytes), which are adapted to contract constantly in a coordinated fashion. This is vital to the survival of the organism given the central role of the heart in the maintenance of the cardiovascular system that delivers oxygen, metabolic substrates and hormones ...
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Advances in Pediatrics, 1998
Concentrative and facilitative glucose transporters are responsible for the movement of glucose across the plasma membrane of human cells. Defects in concentrative glucose transporters cause renal glycosuria and glucose-galactose malabsorption. Alterations in facilitative glucose transporters explain the newly discovered syndrome of low CNS glucose in ...
N, Longo, L J, Elsas
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Concentrative and facilitative glucose transporters are responsible for the movement of glucose across the plasma membrane of human cells. Defects in concentrative glucose transporters cause renal glycosuria and glucose-galactose malabsorption. Alterations in facilitative glucose transporters explain the newly discovered syndrome of low CNS glucose in ...
N, Longo, L J, Elsas
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The dynamics of the glucose transporter
Trends in Biochemical Sciences, 1988Abstract Recent advances in characterizing the molecular structure and kinetic properties of the human erythrocyte glucose transporter are now starting to give an insight into the dynamics of the transporter.
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