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The dynamics of the glucose transporter
Trends in Biochemical Sciences, 1988Abstract Recent advances in characterizing the molecular structure and kinetic properties of the human erythrocyte glucose transporter are now starting to give an insight into the dynamics of the transporter.
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Diabetes Care, 1992
Three major metabolic abnormalities contribute to hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM) including defective glucose-induced insulin secretion, elevated rates of hepatic glucose output, and insulin's impaired ability to stimulate glucose uptake in peripheral target tissues (insulin resistance). These functions involve cellular
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Three major metabolic abnormalities contribute to hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM) including defective glucose-induced insulin secretion, elevated rates of hepatic glucose output, and insulin's impaired ability to stimulate glucose uptake in peripheral target tissues (insulin resistance). These functions involve cellular
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Structural basis of inhibition of the human SGLT2–MAP17 glucose transporter
Nature, 2021Yange Niu +7 more
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TISSUE GLUCOSE TRANSPORT AND GLUCOSE TRANSPORTERS IN SUCKLING RATS WITH ENDOTOXIC SHOCK
Shock, 1996Hypoglycemia occurs without hyperinsulinemia in suckling rats with endotoxic shock. However, tissue glucose uptake during endotoxic shock is not well known in the newborn. GLUT1 is insulin insensitive and is the predominant glucose transporter in 10 day old rats.
Ciril Krzisnik +3 more
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Biochimica et Biophysica Acta (BBA) - Biomembranes, 1990
The human erythrocyte glucose transporter is a fully integrated membrane glycoprotein having only one N-linked carbohydrate chain on the extracellular part of the molecule. Several authors have suggested the involvement of the carbohydrate moiety in glucose transport, but not definitive results have been published to date. Using transport glycoproteins
Yves Goussault +5 more
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The human erythrocyte glucose transporter is a fully integrated membrane glycoprotein having only one N-linked carbohydrate chain on the extracellular part of the molecule. Several authors have suggested the involvement of the carbohydrate moiety in glucose transport, but not definitive results have been published to date. Using transport glycoproteins
Yves Goussault +5 more
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1993
Decreased peripheral utilization of glucose is an important pathogenic mechanism in diabetes. Although it is universally acknowledged that insulin resistance plays a major role in the reduction of glucose consumption by peripheral tissues, and many defects have been described in the function of insulin receptors (see chapter by Olefsky), indirect ...
Danielle Melloul +3 more
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Decreased peripheral utilization of glucose is an important pathogenic mechanism in diabetes. Although it is universally acknowledged that insulin resistance plays a major role in the reduction of glucose consumption by peripheral tissues, and many defects have been described in the function of insulin receptors (see chapter by Olefsky), indirect ...
Danielle Melloul +3 more
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Exercise training, glucose transporters, and glucose transport in rat skeletal muscles
American Journal of Physiology-Cell Physiology, 1992It was previously found that voluntary wheel running induces an increase in the insulin-sensitive glucose transporter, i.e., the GLUT4 isoform, in rat plantaris muscle (K. J. Rodnick, J. O. Holloszy, C. E. Mondon, and D. E. James. Diabetes 39: 1425-1429, 1990).
Kenneth J. Rodnick +3 more
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Glucose Transport in Lactation
2004Lactose is the major carbohydrate of human milk and is also the major osmotic constituent of human milk. Therefore, synthesis of lactose is the major determinant of the volume of milk produced by the lactating human mammary gland. Lactose issynthesized from free glucose and UDP-galactose.
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Facilitative glucose transport proteins and sodium-glucose co-transporters in the kidney
Current Opinion in Nephrology and Hypertension, 1995Cloning studies have characterized a large gene family of facilitative glucose transporters that are expressed in a tissue-specific manner, and at least two sodium-glucose co-transporters in brush-border membranes of intestinal and renal epithelia. These different transporters play specific roles in glucose transport and homeostasis because of their ...
Brenda B. Hoffman, Fuad N. Ziyadeh
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Sequence and structure of a human glucose transporter.
Science, 1985The amino acid sequence of the glucose transport protein from human HepG2 hepatoma cells was deduced from analysis of a complementary DNA clone. Structural analysis of the purified human erythrocyte glucose transporter by fast atom bombardment mapping ...
M. Mueckler +8 more
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