Results 31 to 40 of about 1,374,974 (361)

Variation in the Glucose Transporter gene SLC2A2 is associated with glycaemic response to metformin

Nature Genetics, 2016
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,
K. Zhou, S. Yee, E. Seiser, N. Leeuwen, R. Tavendale, A. Bennett, C. Groves, R. Coleman, A. A. Heijden, J. Beulens, J. Beulens, C. E. Keyser, L. Zaharenko, Daniel M. Rotroff, M. Out, K. Jablonski, Ling Chen, M. Javorský, J. Židzik, A. Levin, L. Williams, T. Dujic, T. Dujic, S. Semiz, S. Semiz, M. Kubo, Huan-Chieh Chien, S. Maeda, J. Witte, Longyan Wu, I. Tkáč, A. Kooy, R. H. Schaik, C. Stehouwer, L. Logie, MetGen Investigators, Dpp Investigators, Accord Investigators, Accord Investigators, C. Sutherland, J. Kloviņš, V. Pirags, V. Pirags, A. Hofman, B. Stricker, A. Motsinger-Reif, M. Wagner, F. Innocenti, L. Hart, L. Hart, R. Holman, M. McCarthy, M. McCarthy, M. McCarthy, M. Hedderson, C. Palmer, J. Florez, K. Giacomini, E. Pearson   +58 more
semanticscholar   +1 more source

Effects of insulin on glucose transport and glucose transporters in rat heart [PDF]

Biochemical Journal, 1988
The effect of insulin on glucose transport and glucose transporters was studied in perfused rat heart. Glucose transport was measured by the efflux of labelled 3-O-methylglucose from hearts preloaded with this hexose. Insulin stimulated 3-O-methylglucose transport by: (a) doubling the maximal velocity (Vmax); (b) decreasing the Kd from 6.9 to 2.7 mM ...
Bernard Jeanrenaud, R. Greco-Perotto, D. Zaninetti, Françoise Assimacopoulos-Jeannet   +3 more
openaire   +3 more sources

Clinical response to sodium glucose co‐transporter 2 inhibitor ipragliflozin in a patient with metastatic renal cell carcinoma

IJU Case Reports, 2019
Introduction Sodium glucose co‐transporter 2 inhibitors constitute a new class of antidiabetic medication. Sodium glucose co‐transporter 2 inhibitors have been shown to exert anticancer effects.
Keita Izumi, Yasumasa Iimura, Kiyoshi Hiruma, Tsuguhiro Touma, Tetsuro Tsukamoto   +4 more
doaj   +1 more source

Expression of genes of putative hexose transporters in the yeast Hansenula polymorpha are differentially regulated by glucose sensors Hxs1 and Gcr1

Біологічні студії, 2012
The first and limiting step of metabolism of glucose, the most widespread carbon and energy source for majority of cells, is the transport of this sugar across cytoplasmic membrane.
O. G. Stasyk, I. O. Denega, N. O. Sybirna, O. V. Stasyk   +3 more
doaj   +1 more source

Diet-induced insulin resistance altered cardiac GLUT4 and FATP/CD36 expression in rats

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed to investigate the comparative effects of high fat, high sucrose and salt-induced IR on ...
Oladele Ayobami Afolabi, Babatunde Adebola Alabi, Olufemi Oluranti   +2 more
doaj   +1 more source

The The Impact of Dapagliflozin on Aldosterone Hormone in Rats with Heart Failure

Polytechnic Journal, 2023
The latest anti-diabetic medication sodium-glucose co-transporter inhibitor along with the lowering of blood glucose has a cardioprotective and reno-protective effect, it has the ability to reduce the development of heart failure and decrease ...
Skala Mamand Jawhar, Zana Ahmed Mustafa   +1 more
doaj   +1 more source

Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory

Journal of Neuroscience, 2016
The insulin-regulated glucose transporter-4 (GluT4) is critical for insulin- and contractile-mediated glucose uptake in skeletal muscle. GluT4 is also expressed in some hippocampal neurons, but its functional role in the brain is unclear.
Jiah Pearson-Leary, E. McNay
semanticscholar   +1 more source

Antipsychotics inhibit glucose transport: Determination of olanzapine binding site inStaphylococcus epidermidis glucose/H+ symporter

FEBS Open Bio, 2015
The antipsychotic drug olanzapine is widely prescribed to treat schizophrenia and other psychotic disorders. However, it often causes unwanted side effects, including diabetes, due to disruption of insulin‐dependant glucose metabolism through a mechanism
Petr Babkin, Alayna M. George Thompson, Cristina V. Iancu, D. Eric Walters, Jun-yong Choe   +4 more
doaj   +1 more source

More on glucose transporters: The acinar organization for hepatic glucose transport [PDF]

Hepatology, 1991
The “erythroid/brain” glucose transporter (GT) isoform is expressed only in a subset of hepatocytes, those forming the first row around the terminal hepatic venules, while the “liver” GT is expressed in all hepatocytes. After 3 d of starvation, a three- to fourfold elevation of expression of the erythroid/brain GT mRNA and ...
Jorge J. Gumucio, Bahri Bilir, Jorge J. Gumucio   +2 more
openaire   +4 more sources

An evolved xylose transporter from Zymomonas mobilis enhances sugar transport in Escherichia coli

Microbial Cell Factories, 2009
Background Xylose is a second most abundant sugar component of lignocellulose besides glucose. Efficient fermentation of xylose is important for the economics of biomass-based biorefineries.
Zhang Jingqing, Chen Tingjian, Ren Chuan, Liang Ling, Lin Zhanglin   +4 more
doaj   +1 more source