Results 31 to 40 of about 204,438 (163)

Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs

Neural Plasticity, 2018
Glucose is a fundamental source of energy for mammalian cells; however, whether glucose is taken up through the lateral walls of cochlear outer hair cells (OHCs) is unknown. The OHC lateral wall is complex, composed of a plasma membrane, cortical lattice,
Xiao-ting Cheng, Feng-bo Yang, Qing-qing Jiang, Rong Zhang, Shi-ming Yang, Ning Yu   +5 more
doaj   +1 more source

Sodium-glucose transporter 2 inhibitors and their antiarrhythmic role: New insights and future perspective

Acta Marisiensis - Seria Medica
Sodium-glucose transporter 2 inhibitors have been identified as pleiotropic pharmacological agents with demonstrated efficacy in a wide range of pathologies.
Prația-Aron Diana-Ioana, Cozac Dan-Alexandru, Scridon Alina   +2 more
doaj   +1 more source

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

Nature Communications, 2020
XylE is a bacterial xylose transporter and homologue of human glucose transporters GLUTs 1-4. HDX-MS, mutagenesis and MD simulations suggest that protonation of a conserved aspartate triggers conformational transition from outward- to inward facing state
Ruyu Jia, Chloe Martens, Mrinal Shekhar, Shashank Pant, Grant A. Pellowe, Andy M. Lau, Heather E. Findlay, Nicola J. Harris, Emad Tajkhorshid, Paula J. Booth, Argyris Politis   +10 more
doaj   +1 more source

Effects of glucocorticoids on the gene expression of nutrient transporters in different rabbit intestinal segments

Animal, 2020
Glucocorticoids (GCs) are counterregulatory hormones with broad effects on the digestion and absorption of dietary carbohydrates, lipids and proteins, but the underlying molecular mechanisms of these effects remain unclear.
H. Liu, L. Liu, F. Li
doaj   +1 more source

Integrated control of transporter endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5

eLife, 2014
After endocytosis, membrane proteins can recycle to the cell membrane or be degraded in lysosomes. Cargo ubiquitylation favors their lysosomal targeting and can be regulated by external signals, but the mechanism is ill-defined. Here, we studied the post-
Michel Becuwe, Sébastien Léon
doaj   +1 more source

Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake. [PDF]

PLoS ONE, 2016
Transmissible gastroenteritis virus (TGEV) is a coronavirus that causes villus atrophy, followed by crypt hyperplasia, reduces the activities of intestinal digestive enzymes, and disrupts the absorption of intestinal nutrients.
Lei Dai, Wei Wei Hu, Lu Xia, Mi Xia, Qian Yang   +4 more
doaj   +1 more source

Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload‐Induced Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Alterations of energetic metabolism are suggested to be an important contributor to pressure overload (PO)‐induced heart failure. Our previous study reveals that knockout of endothelial Sirtuin 3 (SIRT3) alters glycolysis and impairs diastolic
Heng Zeng, Xiaochen He, Jian‐Xiong Chen   +2 more
doaj   +1 more source

Effect of Exercise and Insulin Signaling on Glucose Transporter Type 4 in Skeletal Muscles: A narrative review

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2023
Introduction: Glucose transporter type 4 (GLUT4) is a membrane glucose transporter that is influenced by insulin signaling and muscle contraction.
Akbar Ghalavand, Marya Rahmani Ghobadi
doaj  

Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity

Cellular Physiology and Biochemistry, 2017
Background/Aims: Rodent islets are often used for basic science research but they do not always recapitulate signalling events in human islets. This study evaluated the glucose-dependent responses of human and mouse islets in terms of dynamic insulin ...
Attilio Pingitore, Inmaculada Ruz-Maldonado, Bo Liu, Guo Cai Huang, Pratik Choudhary, Shanta J. Persaud   +5 more
doaj   +1 more source

Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa

Malaria Journal, 2011
Glucose is the primary source of energy and a key substrate for most cells. Inhibition of cellular glucose uptake (the first step in its utilization) has, therefore, received attention as a potential therapeutic strategy to treat various unrelated ...
Derbyshire Elvira T, Krishna Sanjeev, Slavic Ksenija, Staines Henry M   +3 more
doaj   +1 more source