Results 51 to 60 of about 408,864 (383)

Diet-induced insulin resistance altered cardiac GLUT4 and FATP/CD36 expression in rats

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed to investigate the comparative effects of high fat, high sucrose and salt-induced IR on ...
Oladele Ayobami Afolabi, Babatunde Adebola Alabi, Olufemi Oluranti   +2 more
doaj   +1 more source

The The Impact of Dapagliflozin on Aldosterone Hormone in Rats with Heart Failure

Polytechnic Journal, 2023
The latest anti-diabetic medication sodium-glucose co-transporter inhibitor along with the lowering of blood glucose has a cardioprotective and reno-protective effect, it has the ability to reduce the development of heart failure and decrease ...
Skala Mamand Jawhar, Zana Ahmed Mustafa   +1 more
doaj   +1 more source

Sugar metabolism and accumulation in the fruit of transgenic apple trees with decreased sorbitol synthesis. [PDF]

, 2018
Both sorbitol and sucrose are synthesized in source leaves and transported to fruit for supporting fruit growth in tree fruit species of the Rosaceae family.
Cheng, Lailiang, Dandekar, Abhaya M, Li, Mingjun, Li, Pengmin, Ma, Fengwang   +4 more
core   +2 more sources

The glucose sensor in HIT cells is the glucose transporter [PDF]

FEBS Letters, 1987
The nature of the rate‐limiting step for glucose utilization by the clonal insulin‐producing cell line HIT‐T15 has been investigated. In contrast to the situation in islets of Langerhans, we find that the HIT cell glucose metabolism is limited by the rate of entry of glucose into the cell. This is evidenced by the low rate of sugar transport and by the
Mark Stubbs, S. J. H. Ashcroft
openaire   +3 more sources

The association of ¹⁸F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients

Journal of Experimental & Clinical Cancer Research, 2010
Background Positron emission tomography imaging of lung cancers with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose is a non-invasive diagnostic, and prognostic tool that measures tumor metabolism.
Lee Chang Hun, Lee Min Ki, Kim In Joo, Hwang Sang-Hyun, Kim Seong-Jang, Lee Sang-Yull, Lee Eun Yup   +6 more
doaj   +1 more source

An emerging protagonist: Sodium Glucose Co-transporters (SGLTs) as a burgeoning target for the treatment of diabetes mellitus [PDF]

, 2012
Contemporary therapies to rationalize the hyperglycaemia in type 2 diabetes mellitus (T2DM) generally involve insulin-dependent mechanisms and lose their effectiveness as pancreatic b-cell function decreases to a greater extent. The kidney emerges out as
Danish Ahmed, Manju Sharma, Pankaj S Yadav, Vikas Kumar   +3 more
core   +2 more sources

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

Nature Communications, 2020
XylE is a bacterial xylose transporter and homologue of human glucose transporters GLUTs 1-4. HDX-MS, mutagenesis and MD simulations suggest that protonation of a conserved aspartate triggers conformational transition from outward- to inward facing state
Ruyu Jia, Chloe Martens, Mrinal Shekhar, Shashank Pant, Grant A. Pellowe, Andy M. Lau, Heather E. Findlay, Nicola J. Harris, Emad Tajkhorshid, Paula J. Booth, Argyris Politis   +10 more
doaj   +1 more source

Astrocytes and neurons communicate via a monocarboxylic acid shuttle [PDF]

, 2020
Since formulation of the Astrocyte-Neuron Lactate Shuttle (ANLS) hypothesis in 1994, the hypothesis has provoked criticism and debate. Our review does not criticise, but rather integrates experimental data characterizing proton-linked monocarboxylate ...
Cottrell, Graeme S., Roosterman, Dirk
core   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source