Results 61 to 70 of about 365,436 (354)

Modulation of Glucose Takeup by Glucose Transport on the Isolated OHCs

Neural Plasticity, 2018
Glucose is a fundamental source of energy for mammalian cells; however, whether glucose is taken up through the lateral walls of cochlear outer hair cells (OHCs) is unknown. The OHC lateral wall is complex, composed of a plasma membrane, cortical lattice,
Xiao-ting Cheng, Feng-bo Yang, Qing-qing Jiang, Rong Zhang, Shi-ming Yang, Ning Yu   +5 more
doaj   +1 more source

Transmissible Gastroenteritis Virus Infection Enhances SGLT1 and GLUT2 Expression to Increase Glucose Uptake. [PDF]

PLoS ONE, 2016
Transmissible gastroenteritis virus (TGEV) is a coronavirus that causes villus atrophy, followed by crypt hyperplasia, reduces the activities of intestinal digestive enzymes, and disrupts the absorption of intestinal nutrients.
Lei Dai, Wei Wei Hu, Lu Xia, Mi Xia, Qian Yang   +4 more
doaj   +1 more source

Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer—the relationship with regulatory hypoxia-inducible factor-1α expression, tumor invasiveness, and patient prognosis [PDF]

, 2014
Increased glucose uptake mediated by glucose transporters and reliance on glycolysis are common features of malignant cells. Hypoxia-inducible factor-1α supports the adaptation of hypoxic cells by inducing genes related to glucose metabolism.
Anna Krześlak, AP Demasi, AW Eckert, AW Eckert, BW Kim, C Zhang, CM Douglas, DE Burstein, DW Li, E Cadman, Ewa Brzezińska-Błaszczyk, Ewa Forma, FR Ayala, GL Semenza, H Kaida, H Kaida, Iwona Lewy-Trenda, J Xie, JL Roh, JL Thorne, K Müssig, K Starska, Katarzyna Starska, L Lan, L Zhang, M Kobayashi, M Mueckler, M Shimanishi, Magdalena Bryś, ML Schrijvers, O Koperek, OJ Kwon, Paweł Jóźwiak, R Cabanillas, R Ciampi, R Rashmi, S Kondo, S Ohba, S Zhou, SB Edge, SW Jing, SX Yan, T Yamada, W Fenske, W Ping, X Zhang, XH Chen, XH Wu, XP Sun, Y Cui, Y Kondo, YY Xu   +51 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Sodium-glucose transporter 2 inhibitors and their antiarrhythmic role: New insights and future perspective

Acta Marisiensis - Seria Medica
Sodium-glucose transporter 2 inhibitors have been identified as pleiotropic pharmacological agents with demonstrated efficacy in a wide range of pathologies.
Prația-Aron Diana-Ioana, Cozac Dan-Alexandru, Scridon Alina   +2 more
doaj   +1 more source

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

Nature Communications, 2020
XylE is a bacterial xylose transporter and homologue of human glucose transporters GLUTs 1-4. HDX-MS, mutagenesis and MD simulations suggest that protonation of a conserved aspartate triggers conformational transition from outward- to inward facing state
Ruyu Jia, Chloe Martens, Mrinal Shekhar, Shashank Pant, Grant A. Pellowe, Andy M. Lau, Heather E. Findlay, Nicola J. Harris, Emad Tajkhorshid, Paula J. Booth, Argyris Politis   +10 more
doaj   +1 more source

The role of zinc in renal pathological changes in diabetic status [PDF]

, 2015
Diabetes mellitus (DM) was the 8th leading cause of death in 2011, resulting in 1.4 million deaths worldwide. One of the complications of DM is chronic kidney disease, which accounts for nearly 44% of all new cases of kidney failure in the US in 2011 ...
Fernando, Julie, Zhou, Shaobo
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity

Cellular Physiology and Biochemistry, 2017
Background/Aims: Rodent islets are often used for basic science research but they do not always recapitulate signalling events in human islets. This study evaluated the glucose-dependent responses of human and mouse islets in terms of dynamic insulin ...
Attilio Pingitore, Inmaculada Ruz-Maldonado, Bo Liu, Guo Cai Huang, Pratik Choudhary, Shanta J. Persaud   +5 more
doaj   +1 more source

Endothelial Sirtuin 3 Dictates Glucose Transport to Cardiomyocyte and Sensitizes Pressure Overload‐Induced Heart Failure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Alterations of energetic metabolism are suggested to be an important contributor to pressure overload (PO)‐induced heart failure. Our previous study reveals that knockout of endothelial Sirtuin 3 (SIRT3) alters glycolysis and impairs diastolic
Heng Zeng, Xiaochen He, Jian‐Xiong Chen   +2 more
doaj   +1 more source