Results 91 to 100 of about 2,150,903 (254)

Glucose variability during delirium in diabetic and non-diabetic intensive care unit patients: A prospective cohort study [PDF]

, 2018
Purpose To determine whether glucose variability is altered during delirium days compared to non-delirious days in critically ill patients with and without diabetes in the intensive care unit (ICU).
Slooter, Arjen J C, Eibert R Heerdink, Egberts, Toine C.G., van der Linden, Paul D, Paul D. van der Linden (5978810), Wilma Knol, Arjen J. C. Slooter (475584), Svetlana V Belitser, Slooter, Arjen J.C., Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Knol, Wilma, Kris van Keulen, Toine C. G. Egberts (447045), Heerdink, Eibert R, Wilma Knol (4848094), Irene J Zaal, Toine C G Egberts, Eibert R. Heerdink (5978813), Belitser, Svetlana V., Zaal, Irene J, Irene J. Zaal (475583), Belitser, Svetlana V, van der Linden, Paul D., Kris van Keulen (5978807), Egberts, Toine C G, Paul D van der Linden, Svetlana V. Belitser (135612), Heerdink, Eibert R., Arjen J C Slooter, van Keulen, Kris, Zaal, Irene J., Regenerative Medicine and Stem Cells, Brain, Apotheek Onderzoek, Child Health, Infection & Immunity, PECP - Centre for Pharmacoepidemiology, AIOS Anesthesiologie, MS Geriatrie, Circulatory Health, Medische Staf Intensive Care, PECP – Centre for Clinical Therapeutics   +42 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

US Climate Variability & Predictability Program Science Plan

, 2013
This report discusses the strategic scientific plan for the United States Climate Variability & Predictability ...
U.S. Climate Variability & Predictability Program. Scientific Steering Committee.
core  

Translating Glucose Variability Metrics into the Clinic via Continuous Glucose Monitoring: A Graphical User Interface for Diabetes Evaluation (CGM-GUIDE) [PDF]

, 2011
Background: Several metrics of glucose variability have been proposed to date, but an integrated approach that provides a complete and consistent assessment of glycemic variation is missing.
Renata A. Rawlings, Patrick W. Nelson, William Brehm, Brehm, William, Pop-Busui, Rodica, Yuan, Lo-Hua, Hang Shi, Shi, Hang, Rawlings, Renata A., Lo-Hua Yuan, Nelson, Patrick W., Rodica Pop-Busui   +11 more
core   +1 more source

Future horizons in diabetes: integrating AI and personalized care

Frontiers in Endocrinology
Diabetes is a global health crisis with rising incidence, mortality, and economic burden. Traditional markers like HbA1c are insufficient for capturing short-term glycemic fluctuations, leading to the need for more precise metrics such as Glucose ...
Kaiqi Zhang, Yun Qi, Wenjun Wang, Xinyi Tian, Jiahui Wang, Lili Xu, Xu Zhai   +6 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Variability Of Glucose And Lifestyle In Continuous Glucose Monitoring (CGM) [PDF]

, 2018
Background: Investigation of glucose variability is crucial for patient with Type 1 Diabetes mellitus (T1DM) on insulin treatment. For Continuous Glucose Monitoring (CGM), FreeStyle Libre (Abbott) has been introduced to clinical practice with useful and ...
Kawata, Takafumi, Kawahito, Atsuko, カナガワ, ヒロエ, カワヒト, アツコ, バンドウ, ヒロシ, スエキ, エツコ, Kanazawa, Setsuko, カワタ, タカフミ, カナザワ, セツコ, 185, Tanaka, Mayumi, Bando, Hiroshi, タナカ, マユミ, Sueki, Etsuko, 60228690, Kato, Yoshikane, 板東, 浩, Kanagawa, Hiroe, カトウ, ヨシカネ   +18 more
core  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Increased Postoperative Glycemic Variability Is Associated with Increased Revision Surgery Rates in Diabetic Patients Undergoing Hip Fracture Fixation

Surgical Techniques Development
Background: An association between increased postoperative glycemic variability (GV) and inferior postoperative outcomes following hip arthroplasty procedures has been previously reported.
Itay Ashkenazi, Nissan Amzallag, Shai Factor, Nadav Graif, Or Shaked, Yaniv Warschawski, Tomer Ben-Tov, Amal Khoury   +7 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source