Results 71 to 80 of about 2,150,903 (254)

Effect of exercise on glucose variability in healthy subjects: randomized crossover trial

Biology of Sport, 2019
The aim of this study was to evaluate the acute effect of aerobic (AER) and eccentric (ECC) exercise on glucose variability, correlating it with circulating markers of inflammation and oxidative stress in healthy subjects.
Franciele Ramos Figueira, Daniel Umpierre, Patrícia Martins Bock, Gustavo Waclawovsky, Ana Paula Guerra, Anderson Donelli, Michael Andrades, Karina Rabello Casali, Beatriz D. Schaan   +8 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Estimation of insulin sensitivity from continuous glucose monitoring and insulin pump data in type 1 diabetes [PDF]

, 2012
Diabetes mellitus is a disease characterized by chronic hyperglycemia either due to a lack of secretion of the hormone insulin (Type 1 Diabetes Mellitus, T1DM) or due to impaired action of this hormone (Type 2 Diabetes Mellitus, T2DM).
Ronca, Gabriele
core  

Effects of myo-inositol on glucose variability in women with gestational diabetes

, 2018
Myoinositol supplementation prevents gestational diabetes (GDM) in women at risk and reduces insulin resistance in women with GDM. No data are available about its effects on glucose variability.
Di Vieste, G, Giunta, L, Corrado, F, Lucisano, G, Pintaudi, B, D'Anna, R, Di Benedetto, A   +6 more
core   +1 more source

Glucose variability in pregnant women with newly diagnosed hyperglycemia

Alʹmanah Kliničeskoj Mediciny, 2020
Background: High-performance parallel next-generation sequencing (NGS) allows for identification of various maturity-onset diabetes of the young (MODY) subtypes also during pregnancy. As this method is expensive and time-consuming, it has proposed to use
M. A. Plekhanova, F. F. Burumkulova, V. A. Petrukhin, T. S. Budykina, A. E. Panov   +4 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Alterations in the Levels of Circulating and Endothelial Progenitor Cells Levels in Young Adults with Type 1 Diabetes: A 2-Year Follow-Up from the Observational METRO Study

Diabetes, Metabolic Syndrome and Obesity, 2020
Miriam Longo,1,2 Lorenzo Scappaticcio,1 Giuseppe Bellastella,1,2 Vlenia Pernice,1 Paolo Cirillo,1 Antonietta Maio,1 Filomena Castaldo,1,2 Dario Giugliano,1,2 Katherine Esposito,1,3 Maria Ida Maiorino1,2 On Behalf of the METRO Study Group1Department of ...
Longo M, Scappaticcio L, Bellastella G, Pernice V, Cirillo P, Maio A, Castaldo F, Giugliano D, Esposito K, Maiorino MI   +9 more
doaj  

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

The relationships between glucose variability and renal function in type 2 diabetes patients on basal-bolus insulin therapy

Сахарный диабет, 2015
Aim. To assess the relationship of glucose variability (GV) and renal function in patients with type 2 diabetes on basal-bolus insulin therapy.Materials and methods.
Vadim V. Klimontov, Natalia E. Myakina
doaj   +1 more source