Results 61 to 70 of about 2,049,261 (287)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Glucose level detection using millimetre-wave metamaterial-inspired resonator [PDF]

, 2022
Millimetre-wave frequencies are promising for sensitive detection of glucose levels in the blood, where the temperature effect is insignificant. All these features provide the feasibility of continuous, portable, and accurate monitoring of glucose levels.
N I M Elamin, Qureshi, S.A., Suhail Asghar Qureshi, See, Chan Hwang, Ashyap, A.Y.I., Huda A Majid, Nebhen, J., See, C.H., Jamel Nebhen, M R Kamarudin, Majid, H.A., Chan Hwang See, Abidin, Z.Z., A. Majid, Huda, Abidin, Zuhairiah Zainal, R A Abd-Alhameed, Ashyap, Adel Y. I., Kamarudin, M. R., Zuhairiah Zainal Abidin, Nebhen, Jamel, Adel Y I Ashyap, Qureshi, Suhail Asghar, Elamin, N.I.M., Abd-Alhameed, Raed, Abd-Alhameed, R. A., Elamin, N. I. M., Kamarudin, M.R.   +26 more
core   +1 more source

Role of glucose variability on linear growth in children with type 1 diabetes

Endocrine Connections, 2023
Objective: Linear growth is impaired in children with type 1 diabetes (T1D) and poor metabolic control. A good metabolic control is a key therapeutic goal to prevent vascular complications and also to ensure appropriate anthropometric development during ...
Annalisa Blasetti, Valeria Castorani, Nella Polidori, Ilaria Mascioli, Francesco Chiarelli, Cosimo Giannini   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Glycemic variability and muscle loss in elderly type 2 diabetes: insights from continuous glucose monitoring and chest CT in 303 patients

Frontiers in Endocrinology
PurposeSarcopenia is common among older adults with type 2 diabetes mellitus (T2DM). Although chronic hyperglycemia is known to contribute to muscle loss, it remains unclear whether glucose fluctuations—independent of average glucose levels—also play a ...
Xiao-le Zhang, Ning Bai, Chun-pu Mao, Chun-yan Liu   +3 more
doaj   +1 more source

Assessment of blood glucose variability by continuous monitoring as a therapy guide for patients with diabetic nephropathy on hemodialysis

The Egyptian Journal of Internal Medicine, 2018
Background Plasma glucose variability may confer a risk for development of chronic diabetic complications. Glycosylated hemoglobin (HbA1c) reflects average glucose level but not glucose variability, which is measured by mean amplitude of glycemic ...
Ayman Abd-Elrahman Mohamed Nsr-Allah, Mohamed Kamar, Ahmed Sharawy, Nermin Raafat   +3 more
doaj   +1 more source

Advances in Understanding Glucose Variability and the Role of Continuous Glucose Monitoring [PDF]

European Endocrinology, 2010
Recent data have suggested that glucose variability may add to or modify the risk of diabetes complications. Glycated haemoglobin (HbA 1c ), an integrated measure of sustained chronic hyperglycaemia, fails to reflect glucose variability and the risks associated with extreme glucose swings ...
Lutz Vogt, Klaus-Dieter Kohnert
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Metformin reduces airway glucose permeability and hyperglycaemia-induced Staphylococcus aureus load independently of effects on blood glucose [PDF]

, 2013
Background Diabetes is a risk factor for respiratory infection, and hyperglycaemia is associated with increased glucose in airway surface liquid and risk of Staphylococcus aureus infection.
Garnett, James P, Tregoning, John S, Baines, DL, Baines, Deborah L, Knight, Gwenan M, Naik, S, Lindsay, JA, Tregoning, JS, Naik, Sonam, Garnett, JP, Baker, EH, Lindsay, Jodi A, Gill, S, Baker, Emma H, Gill, Simren, Knight, GM   +15 more
core   +1 more source