Results 41 to 50 of about 2,150,903 (254)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Evidence of Early Diabetic Nephropathy in Pediatric Type 1 Diabetes

Frontiers in Endocrinology, 2021
BackgroundDiabetic nephropathy (DN) is one of the most common microvascular complications in type 1 diabetes Mellitus (T1D). Urinary markers of renal damage or oxidative stress may signal early stages of DN.
Leena Mamilly, Lucy D. Mastrandrea, Claudia Mosquera Vasquez, Brett Klamer, Brett Klamer, Mahmoud Kallash, Ahmad Aldughiem   +6 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Glycemic variability and muscle loss in elderly type 2 diabetes: insights from continuous glucose monitoring and chest CT in 303 patients

Frontiers in Endocrinology
PurposeSarcopenia is common among older adults with type 2 diabetes mellitus (T2DM). Although chronic hyperglycemia is known to contribute to muscle loss, it remains unclear whether glucose fluctuations—independent of average glucose levels—also play a ...
Xiao-le Zhang, Ning Bai, Chun-pu Mao, Chun-yan Liu   +3 more
doaj   +1 more source

Assessment of blood glucose variability by continuous monitoring as a therapy guide for patients with diabetic nephropathy on hemodialysis

The Egyptian Journal of Internal Medicine, 2018
Background Plasma glucose variability may confer a risk for development of chronic diabetic complications. Glycosylated hemoglobin (HbA1c) reflects average glucose level but not glucose variability, which is measured by mean amplitude of glycemic ...
Ayman Abd-Elrahman Mohamed Nsr-Allah, Mohamed Kamar, Ahmed Sharawy, Nermin Raafat   +3 more
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Results of multivariate logistic regression model for glucose variability subgroup.

, 2017
Results of multivariate logistic regression model for glucose variability subgroup.
Jih-Chang Chen (56326), Zhen-Ying Liu (3687529), Yi-Lin Chan (275752), Gerald N. Blaney (3687535), Kuan-Fu Chen (367490), Shen-Che Lin (3687541), Chun-Kuei Chen (3040362), Chin-Chieh Wu (835569), Hsiao-Yun Chao (3687538), Peng-Hui Liu (3687532), Cho-Ju Wu (3687544)   +10 more
core   +1 more source

To Assess Liraglutide’s Therapeutic Effect in Patients with Type 2 Diabetes Mellitus Using Flash Glucose Monitoring System

Diabetes, Metabolic Syndrome and Obesity, 2021
Jianhong Yin,1,* Minmin Han,1,2,* Linhui Li,3 Yang Li,4 Zi’ang Liu,5,6 Jing Yang,1 Yunfeng Liu1 1Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2First Clinical Medical ...
Yin J, Han M, Li L, Li Y, Liu Z, Yang J, Liu Y   +6 more
doaj  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source