Results 31 to 40 of about 2,150,903 (254)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect [PDF]

, 2011
The brain relies upon glucose as its primary fuel. In recent years, a rich literature has developed from both human and animal studies indicating that increases in circulating blood glucose can facilitate cognitive functioning.
Riby, Leigh, Jonathan K. Foster, Riby, L., Michael A. Smith, Smith, M., van Eekelen, A., van Eekelen, Anke, Foster, Jonathan, J. Anke M. van Eekelen, Smith, Michael, Leigh M. Riby   +10 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Ghrelin deficiency in patients with type 2 diabetes: the relationships with obesity, adipose tissue dysfunction and glucose variability [PDF]

Терапевтический архив, 2019
Aim. Ghrelin, a peptide hormone mostly produced by stomach, plays an important role in regulation of feeding behavior, energy balance and glucose homeostasis.
V V Klimontov, D M Bulumbaeva, O N Fazullina, N B Orlov, V I Konenkov   +4 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A moderately higher time-in-range threshold improves the prognosis of type 2 diabetes patients complicated with COVID-19

Frontiers in Endocrinology
ObjectiveAfter fully lifting coronavirus disease 2019 (COVID-19) pandemic control measures in mainland China in 12/2022, the incidence of COVID-19 has increased markedly, making it difficult to meet the general time-in-range (TIR) requirement.
Riping Cong, Jianbo Zhang, Jianbo Zhang, Lujia Xu, Yujian Zhang, Hao Wang, Jing Wang, Wei Wang, Yingli Diao, Haijiao Liu, Jing Zhang, Kuanxiao Tang   +11 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Postprandial glucose variability in type 1 diabetes: The individual matters beyond the meal

, 2022
To explore intraindividual (between-meals) and interindividual (between-subjects) variability of postprandial glucose response (PGR) in type 1 diabetes (T1DM)
Capuano, M, Annuzzi, G, Cavagnuolo, L, Scidà, G, Bozzetto, L, Corrado, A, Costabile, G, Pacella, D, Rivellese, A A   +8 more
core   +1 more source

Glycemic Variability Before and After Hypoglycemia Across Different Timeframes in Type 1 Diabetes with and Without Automated Insulin Delivery

Diabetology
Background: Managing Type 1 diabetes (T1D) aims to optimize glucose within the target range while minimizing hyperglycemia and hypoglycemia, yet exercise complicates glycemic outcomes.
Ahtsham Zafar, Abiodun A. Solanke, Dana M. Lewis, Arsalan Shahid   +3 more
doaj   +1 more source

Continuous glucose monitoring reveals periodontitis-induced glucose variability, insulin resistance, and gut microbiota dysbiosis in mice. [PDF]

Sci Rep
Diabetes mellitus (DM) management has advanced from self-monitoring blood glucose (SMBG) to continuous glucose monitoring (CGM), which better prevents complications.
Kubota-Takamori M, Omori K, Kamei-Nagata C, Kiyama F, Ishii T, Nakayama M, Gotoh K, Hirai K, Shinoda-Ito Y, Okubo K, Nakamura S, Ikeda A, Saito T, Wada J, Takashiba S.   +14 more
europepmc   +2 more sources