Results 201 to 210 of about 99,255 (339)

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

open access: yesCell Proliferation, EarlyView.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su   +5 more
wiley   +1 more source

Structural and functional insights into extreme thermal stability and activity of two GH12 domains of a multidomain glycosidase from a hyperthermophilic euryarchaeon

open access: yesThe FEBS Journal, EarlyView.
The multidomain glycosidase MDG from the hyperthermophilic euryarchaeon Thermococcus sp. contains five protein domains: three catalytic domains (GH5, GH12‐1, and GH12‐2) and two cellulose‐binding modules (CBM2). In this study, the GH12‐1 and GH12‐2 domains were individually purified and biochemically characterized.
Kseniya S. Zayulina   +11 more
wiley   +1 more source

Electrostatic potential as a reactivity scoring function in computer‐assisted enzyme engineering

open access: yesThe FEBS Journal, EarlyView.
We present a computational metric that quantifies the electrostatic complementarity of enzymes to the charge distribution of substrates at the transition state. Implemented in BindScan, this metric accurately predicts functionally relevant mutations in glycoside hydrolases.
Aitor Vega, Antoni Planas, Xevi Biarnés
wiley   +1 more source

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