Results 101 to 110 of about 21,060 (195)

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

open access: yesNeuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng   +9 more
wiley   +1 more source

Trikafta Rescues F508del‐CFTR by Tightening Specific Phosphorylation‐Dependent Interdomain Interactions

open access: yesNatural Sciences, EarlyView.
The most common cystic fibrosis mutation, F508del, destabilizes the first of two nucleotide‐binding domains (NBD1 and NBD2) and compromises Mg/ATP‐dependent gating at the interface between two transmembrane domains (TMD1 and TMD2) in the human cystic fibrosis transmembrane conductance regulator (CFTR).
Guangyu Wang
wiley   +1 more source

Chemical Characterization, Antioxidant and Enzyme‐Inhibitory Activities of Different Extracts from Three Phlomis Species

open access: yesChemistryOpen, EarlyView.
The tested Phlomis species are a rich source of bioactive molecules with potential therapeutic applications, and selecting appropriate extraction solvents is crucial for achieving the targeted biological activity. Phlomis species (family Lamiaceae) are highly valued as food and herbal medicine.
Sakina Yagi   +8 more
wiley   +1 more source

Studies Concerned with the Structure and Synthesis of the Anti‐viral Tropolone Glycoside Liriosmaside A

open access: yesChemistryOpen, EarlyView.
The core of the anti‐viral troponoid natural product liriosmaside A lacking the 3‐hydroxy‐3‐methylglutaric acid (HMGA) side‐chain at C6′ has been prepared. The early steps involved the gem‐dibromocyclopropane‐mediated ring‐expansion of a readily‐obtained Robinson annulation product.
Qi Chen   +9 more
wiley   +1 more source

Quality Control of Shenqi Tongmai Oral Liquid Based on Quantitative Analysis of Multicomponents by Single Marker, Molecular Docking, and Multivariate Statistics

open access: yesPhytochemical Analysis, EarlyView.
ABSTRACT Introduction Shenqi Tongmai oral liquid (SQTM) is famous for its remarkable effect in the treatment of cardiovascular diseases. However, the SQTM quality evaluation system has not been established. Objective The objective of this study is to establish a method for the determination of nine components of SQTM and to screen quality control ...
Qian Li   +6 more
wiley   +1 more source

Quality Control Strategies for Differentiation of Kalanchoe Species

open access: yesPhytochemical Analysis, EarlyView.
ABSTRACT Kalanchoe species products are commercially available in local markets and by internationally accessible online retailers and may exhibit quality issues because of misidentification from similar common names and anatomical similarities among related species used as feedstock. This study proposes an approach using UPLC‐MS/MSE and HPTLC, coupled
Evelyn A. de Andrade   +8 more
wiley   +1 more source

Anti‐Inflammatory Saponins From an Edible Aquatic Plant Nymphoides hydrophylla

open access: yesPhytochemical Analysis, EarlyView.
ABSTRACT Introduction The present investigation of Nymphoides hydrophylla is a Taiwan indigenous edible aquatic plant, belongs to the Menyanthaceae family, and has been used as a traditional food with potential medicinal values against fever, insect bites, ulcer, and skin diseases.
Ching‐Yeu Chen   +6 more
wiley   +1 more source

Irrigation using slightly saline water from emerging desalination technologies as a solution to short‐term drought

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
With global weather patterns becoming more extreme and unpredictable, sourcing reliable irrigation water is vital for improving food security and conserving drinking water in drought‐prone areas. Emerging desalination technologies, which are still in the development phase, could potentially provide large quantities of slightly saline water for ...
Harry Myrans   +5 more
wiley   +1 more source

A comprehensive review of the genetic control of cooking time in dry beans (Phaseolus vulgaris L.)

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Reducing cooking time could increase dry beans (Phaseolus vulgaris) consumption. Cooking is an essential processing step needed to unlock the nutrients in dry beans and to make them palatable and safe for consumption. Long cooking times have consequences for dry bean use, especially where cooking fuel cost is high and when people prefer foods that are ...
Hannah R. Jeffery   +3 more
wiley   +1 more source

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