Results 271 to 280 of about 51,146 (287)

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

<i>Gymnadenia conopsea</i> orchid: a systematic review. [PDF]

Front Pharmacol
Wu JY, Tang RN, Wang JW, Chen WY, Liu X, Wang JW, Li MY, Jiang FS.   +7 more
europepmc   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, Volume 13, Issue 2, 9 January 2026.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

The State of Knowledge of the Primary and Secondary Metabolites of the Iris Genus. [PDF]

Chem Biodivers
Mykhailenko O, Ivanauskas L, Georgiyants V, Gudžinskas Z.   +3 more
europepmc   +1 more source

Ex Vivo Spatiotemporal Characterization of Spermatogenesis in Mouse Testicular Organoids

Advanced Science, Volume 13, Issue 4, 19 January 2026.
To date, in vitro spermatogenesis remains a challenge in reproductive medicine. In this study, Sun et al. developed a promising in vitro strategy to generate testicular organoids that enable germ cells from newborn mice to enter meiosis, complete chromosome recombination and synapsis, and develop into haploid spermatids.
Jiachen Sun, Lifa Zhu, Yutong Li, Jinyan Tang, Tao Zhang, Hengjia Zhang, Wanchu Wang, Lufan Li, Shuhui Bian, Xin Wu   +9 more
wiley   +1 more source

Substrate Selectivities of GH78 α-L-Rhamnosidases from Human Gut Bacteria on Dietary Flavonoid Glycosides. [PDF]

Molecules
Li BC, Wu B, Hou X, Ding GB.
europepmc   +1 more source

Integrative Omics Defines Metabolic Biomarkers and Genetic Regulatory Mechanisms of Mortality Risk

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Understanding mortality mechanisms remains a fundamental challenge. Through multi‐omics analysis of a three‐generation chicken model, are identified 45,585 mQTLs and establish a 16‐metabolite predictor of mortality. An inflammation‐growth trade‐off and evolutionarily conserved pathways involving butyrate–microbiota interactions and L‐cysteine's dual ...
Peihao Liu, Bingxing An, Jumei Zheng, Qiao Wang, Zhirui Yang, Zhengda Li, Dawei Liu, Fan Ying, Jie Wen, Lingzhao Fang, Guiping Zhao   +10 more
wiley   +1 more source

Natural Products Chemistry [PDF]

, 2001
幸田 恭治, 手塚 康弘, 畑中 保丸, 門田 重利   +3 more
core   +1 more source

Heat drastically alters floral color and pigment composition without affecting flower conspicuousness

American Journal of Botany, Volume 113, Issue 1, January 2026.
Abstract Premise Floral pigments primarily serve to attract pollinators through color display and also contribute to protection against environmental stress. Although pigment composition can be plastically altered under stress, its impact on pollinator color perception remains poorly understood.
Eduardo Narbona, Francisco Perfectti, Adela González‐Megías, Luis Navarro, José C. del Valle, Cristina Armas, José M. Gómez   +6 more
wiley   +1 more source

Plant Immunity-Activating Endophytic Bacteria Induce Dynamic Metabolic Changes in Cultured Plant Cells Without Inhibiting Their Growth. [PDF]

Microb Biotechnol
Aikawa Y, Yabuuchi A, Kaneko H, Hashimoto T, Kuchitsu K, Furuya T.   +5 more
europepmc   +1 more source