Results 101 to 110 of about 3,930 (214)

Piceatannol, a Natural Polyphenol From Grape, Inhibits Helicobacter pylori Through Targeted Suppression of Its Secreted Urease

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
Piceatannol significantly inhibits the growth of Helicobacter pylori through targeted suppression of its secreted urease activity. The inhibition of piceatannol against H. pylori urease (HPU) and jack bean urease (JBU) was characterized in a slow‐binding, mixed‐type and slow‐binding, noncompetitive type, respectively.
Qiang Lu, Yuhong Xie, Xuefei Wang, Haohui Chen, Yifei Xu, Cailan Li   +5 more
wiley   +1 more source

oxLDL and eLDL Induced Membrane Microdomains in Human Macrophages. [PDF]

PLoS ONE, 2016
Extravasation of macrophages and formation of lipid-laden foam cells are key events in the development and progression of atherosclerosis. The degradation of atherogenic lipoproteins subsequently leads to alterations in cellular lipid metabolism that ...
Stefan Wallner, Margot Grandl, Gerhard Liebisch, Markus Peer, Evelyn Orsó, Alexander Sigrüner, Andrzej Sobota, Gerd Schmitz   +7 more
doaj   +1 more source

Ferroptosis in Haematological Malignancies: From Regulatory Networks to Novel Therapeutic Opportunities

Journal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Haematological malignancies encompass a wide spectrum of blood cell disorders with diverse prognoses. Despite recent advances in therapy, many of these disorders remain incurable or exhibit relapse and drug resistance. Ferroptosis, an iron‐dependent form of cell death caused by lipid peroxidation, holds promise as a strategy to overcome the ...
Maryam Shayanmanesh, Seyed Esmaeil Ahmadi, Ali Amini   +2 more
wiley   +1 more source

Transcriptome profiling of a spirodiclofen susceptible and resistant strain of the European red mite Panonychus ulmi using strand-specific RNA-seq [PDF]

, 2015
Background: The European red mite, Panonychus ulmi, is among the most important mite pests in fruit orchards, where it is controlled primarily by acaricide application.
Bajda, Sabina, Clark, Richard M, Dermauw, Wannes, Greenhalgh, Robert, Nauen, Ralf, Tirry, Luc, Van Leeuwen, Thomas   +6 more
core   +17 more sources

Courtship Is a Major Factor of Mating‐Shortened Male Lifespan in an Egg Parasitoid

Ecology and Evolution, Volume 15, Issue 8, August 2025.
Mating is vital for population survival but often leads to reduced post‐mating longevity in both sexes. In many insects, sperm‐related factors are thought to cut male longevity, while in Anastatus disparis, mating also affects male longevity, with courtship being the main cause. Transcriptomic analyses of A.
Zi‐Yin Wang, Jing Li, Jia‐Min Tang, Lan‐Feng Qiu, Hao‐Yuan Hu, Peng‐Cheng Liu   +5 more
wiley   +1 more source

Molecular basis and clinical management of Gaucher disease

Cardiogenetics, 2013
Gaucher disease (GD) type I is an autosomal recessive disease caused by a genetic deficiency of lysosomal β-glucocerebrosidase that leads to accumulation of undergraded substrate glucocerebroside and other glycolipids, thus causing damage in ...
Maja Di Rocco, Andrea Loggini, Pierluigi Russo   +2 more
doaj   +1 more source

Thirty-year clinical outcomes after haematopoietic stem cell transplantation in neuronopathic Gaucher disease

Orphanet Journal of Rare Diseases, 2022
Background Neuronopathic Gaucher Disease (nGD) describes the condition of a subgroup of patients with the Lysosomal Storage Disorder (LSD), Gaucher disease with involvement of the central nervous system (CNS) which results from inherited deficiency of β ...
Aimee Donald, Cecilia Kämpe Björkvall, Ashok Vellodi, GAUCHERITE Consortium, Timothy M. Cox, Derralyn Hughes, Simon A. Jones, Robert Wynn, Maciej Machaczka   +8 more
doaj   +1 more source

Enhancing Functional Protein Design Using Heuristic Optimization and Deep Learning for Anti‐Inflammatory and Gene Therapy Applications

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 7, Page 1238-1256, July 2025.
ABSTRACT Protein sequence design is a highly challenging task, aimed at discovering new proteins that are more functional and producible under laboratory conditions than their natural counterparts. Deep learning‐based approaches developed to address this problem have achieved significant success.
Ayşenur Soytürk Patat, Özkan Ufuk Nalbantoğlu   +1 more
wiley   +1 more source

Eye movement biomarkers allow for the definition of phenotypes in Gaucher Disease

Orphanet Journal of Rare Diseases, 2020
Background Neurological forms of Gaucher disease, the inherited disorder of β-Glucosylceramidase caused by bi-allelic variants in GBA1, is a progressive disorder which lacks a disease-modifying therapy.
Aimee Donald, Chong Y. Tan, Anupam Chakrapani, Derralyn A. Hughes, Reena Sharma, Duncan Cole, Stanislav Bardins, Martin Gorges, Simon A. Jones, Erich Schneider   +9 more
doaj   +1 more source

Beta2-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes. [PDF]

, 2014
Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium dye 3-(4,5-dimethylthi-azol-2 ...
Appelqvist, Argilés, Baglioni, Beattie, Beaufay, Berridge, Berthelot, Boot, Bucciantini, Casey, Chafekar, Chiti, Colvin, Cremades, Dehay, Dell'Angelica, Desplats, Eisenberg, Eskelinen, Follett, Friedrich, García-García, Gharibyan, Goodchild, Grudzielanek, Halle, Harold, Heegaard, Isobe, Jahn, Jiang, Julien, Kanatsu, Kayed, Kepp, Kerokoski, Khurana, Kubo, Kurz, Kågedal, Lee, Lee, Lesné, Liu, Liu, Liu, Lorincz, Macia, MacLeod, Martins, Mazzulli, Milanesi, Monti, Morten, Mossuto, Mossuto, Myers, Münch, Nekooki-Machida, Nesterov, Nixon, Novitskaya, Petkova, Pieri, Pols, Porter, Reixach, Ren, Shankar, Sheynis, Simoneau, Sims, Sipe, Sorkin, Soura, Stefani, Torres, Treusch, Uversky, Villamil Giraldo, Walsh, Winner, Xue, Xue, Xue, Zhang, Zhang, Zhao   +87 more
core   +2 more sources