Results 111 to 120 of about 3,748 (212)

Altered gene expression in highly purified enterocytes from patients with active coeliac disease [PDF]

, 2008
Background Coeliac disease is a multifactorial inflammatory disorder of the intestine caused by ingestion of gluten in genetically susceptible individuals.
Suzanne Bracken, Greg Byrne, Jacinta Kelly, John Jackson, Conleth Feighery   +4 more
core   +2 more sources

Phylogenetic and chronological analysis of proteins causing Alzheimer's, Parkinson's and Huntington's diseases [PDF]

, 2012
It is evident that Neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's) have many similarities at cellular and molecular level as they carry parallel mechanisms including protein aggregation and inclusion body formation caused by ...
Bilal Hussain, Hina Khalid, Saima Aslam, Shahid Nadeem, Tayyaba Sultana   +4 more
core  

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.

PLoS Genetics
Mutations in GBA (glucosylceramidase beta), which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the strongest genetic risk factor for the neurodegenerative disorders Parkinson's disease (PD) and Lewy body dementia.
Evelyn S Vincow, Ruth E Thomas, Gillian Milstein, Gautam Pareek, Theo K Bammler, James MacDonald, Leo J Pallanck   +6 more
doaj   +1 more source

Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]

, 2015
No abstract ...
Alvarez-Curto, Elisa, Caltabiano, Gianluigi Caltabiano, Liste, María José Varela, Marsango, Sara, Milligan, Graeme   +4 more
core   +1 more source

Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes.

PLoS ONE, 2015
Gaucher disease is characterized by lysosomal accumulation of glucosylceramide due to deficient activity of lysosomal glucocerebrosidase (GBA). In cells, glucosylceramide is also degraded outside lysosomes by the enzyme glucosylceramidase 2 (GBA2) of ...
Daniela Herrera Moro Chao, Wouter W Kallemeijn, Andre R A Marques, Marie Orre, Roelof Ottenhoff, Cindy van Roomen, Ewout Foppen, Maria C Renner, Martina Moeton, Marco van Eijk, Rolf G Boot, Willem Kamphuis, Elly M Hol, Jan Aten, Hermen S Overkleeft, Andries Kalsbeek, Johannes M F G Aerts   +16 more
doaj   +1 more source

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential [PDF]

, 2015
Autophagy is a conserved homeostatic process active in all human cells and affecting a spectrum of diseases. Here we use a pharmaceutical screen to discover new mechanisms for activation of autophagy.
Ahmed, Zahra, Arko-Mensah, John, Bhaskar, Kiran, Blanchet, Fabien, Bradfute, Steven B., Chauhan, Santosh, Deretic, Vojo, Jiang, Shanya, Kimura, Tomonori, Mandell, Michael A., Maphis, Nicole, Mudd, Michal H., Piguet, Vincent, Sklar, Larry, Timmins, Graham S., Waller, Anna, Won Choi, Seong   +16 more
core   +3 more sources

Patterns of prokaryotic lateral gene transfers affecting parasitic microbial eukaryotes [PDF]

, 2013
Background: The influence of lateral gene transfer on gene origins and biology in eukaryotes is poorly understood compared with those of prokaryotes.
Alsmark, Cecilia, Foster, Peter G, Hirt, Robert P, Martin Embley, T, Nakjang, Sirintra, Sicheritz-Pontén, Thomas   +5 more
core   +3 more sources

Delineating pathological pathways in a chemically-induced mouse model of Gaucher disease [PDF]

, 2016
Great interest has been shown in understanding the pathology of Gaucher disease (GD), due to the recently discovered genetic relationship with Parkinson's disease. For such studies, suitable animal models of GD are required.
Eilam, R, Futerman, AH, Kenwood, BM, Klein, AD, Massaro, G, Merrill, AH, Meshcheriakova, A, Rahim, AA, Vardi, A, Vitner, EB, Yaacobi, C, Zigdon, H   +11 more
core   +1 more source

Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease. [PDF]

, 2016
Glucocerebrosidase (GBA1) gene mutations increase the risk of Parkinson disease (PD). While the cellular mechanisms associating GBA1 mutations and PD are unknown, loss of the glucocerebrosidase enzyme (GCase) activity, inhibition of autophagy and ...
Doherty, MK, Gegg, ME, Magalhaes, J, Migdalska-Richards, A, Schapira, AH, Whitfield, PD   +5 more
core   +2 more sources

Ruthenibacterium lactatiformans gen. nov., sp.nov., an anaerobic, lactate-producing member of the family Ruminococcaceae isolated from human faeces [PDF]

, 2016
Two novel strains of Gram-stain-negative, rod-shaped, obligately anaerobic, non-spore-forming, non-motile bacteria were isolated from the faeces of healthy human subjects.
Bozhenko, Vladimir K., Chaplin, Andrei V., Efimov, Boris A., Kafarskaia, Lyudmila I., Shcherbakova, Victoria A., Shkoporov, Andrei N., Suzina, Natalia E.   +6 more
core   +1 more source