Results 101 to 110 of about 3,748 (212)

Genome-Wide Expression Analysis in Drosophila Reveals Genes Controlling Circadian Behavior [PDF]

, 2002
In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation.
Ceriani, Maria Fernanda, Hogenesch, John B., Kay, Steve A., Panda, Satchidananda, Straume, Martin, Yanovsky, Marcelo Javier   +5 more
core   +1 more source

Progress of non‐motor symptoms in early‐onset Parkinson's disease

Ibrain, Volume 11, Issue 4, Page 422-438, Winter 2025.
This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang, Aidi Luo, Shusheng Liao, Mei Liu, Jun Zhang, Zucai Xu   +5 more
wiley   +1 more source

Sex-biased gene expression in the brown alga Fucus vesiculosus [PDF]

, 2013
Background The fucoid brown algae (Heterokontophyta, Phaeophyceae) are increasingly the focus of ecological genetics, biodiversity, biogeography and speciation research. The molecular genetics underlying mating system variation, where repeated dioecious
Martins, Maria João F., Mota, Catarina, Pearson, G. A.   +2 more
core   +1 more source

Parkinson's Disease and Cancer: Mechanistic Insights and Therapeutic Opportunities From Cancer Neuroscience

MedComm – Oncology, Volume 4, Issue 4, December 2025.
Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan, Lin Yuan, Ruoyang Zhao, Liting Lu, Yinghao Zhi, Yuying Li, Min Wu, Yongye Huang   +7 more
wiley   +1 more source

Beta2-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes. [PDF]

, 2014
Fragmentation of amyloid fibrils produces fibrils that are reduced in length but have an otherwise unchanged molecular architecture. The resultant nanoscale fibril particles inhibit the cellular reduction of the tetrazolium dye 3-(4,5-dimethylthi-azol-2 ...
Appelqvist, Argilés, Baglioni, Beattie, Beaufay, Berridge, Berthelot, Boot, Bucciantini, Casey, Chafekar, Chiti, Colvin, Cremades, Dehay, Dell'Angelica, Desplats, Eisenberg, Eskelinen, Follett, Friedrich, García-García, Gharibyan, Goodchild, Grudzielanek, Halle, Harold, Heegaard, Isobe, Jahn, Jiang, Julien, Kanatsu, Kayed, Kepp, Kerokoski, Khurana, Kubo, Kurz, Kågedal, Lee, Lee, Lesné, Liu, Liu, Liu, Lorincz, Macia, MacLeod, Martins, Mazzulli, Milanesi, Monti, Morten, Mossuto, Mossuto, Myers, Münch, Nekooki-Machida, Nesterov, Nixon, Novitskaya, Petkova, Pieri, Pols, Porter, Reixach, Ren, Shankar, Sheynis, Simoneau, Sims, Sipe, Sorkin, Soura, Stefani, Torres, Treusch, Uversky, Villamil Giraldo, Walsh, Winner, Xue, Xue, Xue, Zhang, Zhang, Zhao   +87 more
core   +2 more sources

Splenic Artery Aneurysm in Gaucher Disease: A Hybrid Study Combining Case Report, Scoping Review, and Clinical Survey

JIMD Reports, Volume 66, Issue 6, November 2025.
ABSTRACT Gaucher disease (GD) is a rare lysosomal storage disorder caused by pathogenic variants in the GBA gene. Splenic artery aneurysm (SAA) is an uncommon and underrecognized complication of GD, particularly in the absence of traditional risk factors. SAA carries a high risk of rupture and significant mortality.
Paolo Manzi, Anita Vergatti, Veronica Abate, Nadia Altavilla, Michelina Sibilio, Pietro Venetucci, Paolo Tirelli, Domenico Rendina, Antonio Barbato   +8 more
wiley   +1 more source

Effects of X‐Ray Irradiation on the Biological Parameters, Gut Microbiota, and Gene Expression of Bactrocera dorsalis: Implications for the Sterile Insect Technique

Evolutionary Applications, Volume 18, Issue 10, October 2025.
ABSTRACT The sterile insect technique (SIT), traditionally reliant on gamma irradiation, has been an effective strategy for controlling Bactrocera dorsalis. However, strict regulations governing gamma radiation sources and the limited research on the responses of B. dorsalis to X‐ray irradiation have hindered the further development of SIT.
Jia Lin, Wensha Ding, Jun Chen, Guoqing Yue, Bo Wang, Qing'e Ji   +5 more
wiley   +1 more source

Role of glucosylceramidase in cutaneous melanoma

, 2021
Cutaneous melanoma (CM) is the most severe skin cancer whom the incidence is keeping growing. Despite of the remarkable improvement of CM management thanks to the development of targeted therapies and immune checkpoint inhibitors, the prognostic of CM patients remains still bad. Some alterations in sphingolipid (SL) metabolism have been described in CM
openaire   +1 more source

Xylan degrading enzymes from fungal sources [PDF]

, 2015
Fungi have the ability to degrade xylan as the major component of plant cell wall hemicellulose. Fungi have evolved batteries of xylanolytic enzymes that concertedly act to depolymerise xylan backbones decorated with variable carbohydrate branches. As an
Connerton, Ian F., Kirikyali, N.
core   +2 more sources

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development

Journal of Neurochemistry, Volume 169, Issue 10, October 2025.
Ceramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Kaviya Chinnappa, Fiona Ballorin, Fiona Francis   +2 more
wiley   +1 more source