Results 61 to 70 of about 3,748 (212)

Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder proteomic profiles [PDF]

, 2017
Hulme, Charlotte H. & Wilson, Emma L. - Equal contributorsBackground Autologous chondrocyte implantation (ACI) can be used in the treatment of focal cartilage injuries to prevent the onset of osteoarthritis (OA).
AI Vasara, B Hopwood, BT Sherman, Charlotte H. Hulme, CM Stoscheck, CT Thorpe, D Saris, D Seny de, DA Wolff, Deborah M. Simpson, DL Cecil, DS Gibson, E Ehrich, E Roos, Emma L. Wilson, F Ceuninck De, FE Watt, G Knutsen, G Murphy, H Smith, H Zreiqat, I Tchetverikov, J Lysholm, J Mateos, J Shen, J Wanner, JA Vizcaino, James B. Richardson, JB Richardson, K Nganvongpanit, Karina T. Wright, KT Wright, LA Collins-Racie, Mandy J. Peffers, MF Hsueh, MF Pietschmann, MJ Peffers, MJ Peffers, MK Lotz, MN Dugard, N Balmain, P Germain, P Niemeyer, P Niemeyer, P Niemeyer, Pete Gallacher, PK Jaiswal, PM Jungmann, R Serra, RR Yammani, S Hartwig, S Roberts, Sally Roberts, SD Gillogly, SM Wasilko, SY Ritter, V Kraus, VB Kraus, W Liao, W Liao, X Yang, Y Su, Y Yoshihara   +62 more
core   +1 more source

Transcriptome profiling of a spirodiclofen susceptible and resistant strain of the European red mite Panonychus ulmi using strand-specific RNA-seq [PDF]

, 2015
Background: The European red mite, Panonychus ulmi, is among the most important mite pests in fruit orchards, where it is controlled primarily by acaricide application.
Bajda, Sabina, Clark, Richard M, Dermauw, Wannes, Greenhalgh, Robert, Nauen, Ralf, Tirry, Luc, Van Leeuwen, Thomas   +6 more
core   +17 more sources

Preclinical insights into fucoidan as a nutraceutical compound against perfluorooctanoic acid-associated obesity via targeting endoplasmic reticulum stress

Frontiers in Nutrition, 2022
Obesity is a growing global health problem; it has been forecasted that over half of the global population will be obese by 2030. Obesity is complicated with many diseases, such as diabetes and cardiovascular diseases, leading to an economic impact on ...
Jiaqi Liu, Chao Guo, Yuqin Wang, Min Su, Wenjun Huang, Keng Po Lai   +5 more
doaj   +1 more source

The influence of dysregulated lipid metabolism on the progression of Parkinson's disease and its clinical implications

Chinese Journal of Contemporary Neurology and Neurosurgery
Lipid metabolism may play a role in the onset and progression of Parkinson's disease （PD）, involving various pathological mechanisms such as abnormal folding and accumulation of α‑synuclein (α‑Syn), ferroptosis, GBA1 gene mutation, and mitochondrial ...
XU Ying, GUI Ya‑xing
doaj   +1 more source

Acid Sphingomyelinase Regulates the Localization and Trafficking of Palmitoylated Proteins [PDF]

, 2019
In human, loss of Acid Sphingomeylinase (ASM/SMPD1) causes Niemann-Pick Disease, type A. ASM hydrolyzes sphingomyelins to produce ceramides but protein targets of ASM remain largely unclear. ...
Kim, Yongsoon, Lee, Chia-Fang, Li, Wenjing, Sun, Hong, Xiong, Xiahui, Yu, Jiekai, Zhang, Hul, Zhu, Linyu   +7 more
core   +2 more sources

Gaucher disease: A 10 year old girl with anemia and huge spelenomegaly (a case report)

, 2008
Gaucher's disease is a rare lipid storage disorder, affecting one in 40,000-200,000 people and results from a genetic deficiency of the enzyme glucocerebrosidase (glucosylceramidase).
Davarian, A., Mirbehbahani, N.B.
core   +1 more source

Transcriptomic characterization of tissues from patients and subsequent pathway analyses reveal biological pathways that are implicated in spastic ataxia

Cell & Bioscience, 2022
Background Spastic ataxias (SAs) encompass a group of rare and severe neurodegenerative diseases, characterized by an overlap between ataxia and spastic paraplegia clinical features. They have been associated with pathogenic variants in a number of genes,
Andrea C. Kakouri, Christina Votsi, Anastasis Oulas, Paschalis Nicolaou, Massimo Aureli, Giulia Lunghi, Maura Samarani, Giacomo M. Compagnoni, Sabrina Salani, Alessio Di Fonzo, Thalis Christophides, George A. Tanteles, Eleni Zamba-Papanicolaou, Marios Pantzaris, George M. Spyrou, Kyproula Christodoulou   +15 more
doaj   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

A novel mutation in the GBA2 gene in a Japanese patient with SPG46: A case report

eNeurologicalSci, 2020
Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder characterized by pyramidal weakness and spasticity of the lower limbs. SPG46, one of autosomal recessive HSP, is clinically characterized by spasticity and pyramidal weakness of the ...
Keiko Nakamura-Shindo, Kenjiro Ono, Kishin Koh, Hiroyuki Ishiura, Shoji Tsuji, Yoshihisa Takiyama, Masahito Yamada   +6 more
doaj   +1 more source

Autosomal recessive cerebellar ataxia with spasticity due to a rare mutation in GBA2 gene in a large consanguineous Saudi family

Genes and Diseases, 2021
The nonlysosomal glucosylceramidase β2 (GBA2) gene encode an enzyme that catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. Mutations in the GBA2 gene have been reported to cause hereditary spastic paraplegia, autosomal recessive ...
Hussein Algahtani, Bader Shirah, Ikram Ullah, Mohammad H. Al-Qahtani, Angham Abdulrahman Abdulkareem, Muhammad Imran Naseer   +5 more
doaj   +1 more source