Fermentation, 2023 The purpose of this study was to investigate the effects of replacing a portion of whole-plant corn silage with straw on the rumen microbial community structure and carbohydrate-active enzyme activity.
Yubin Ma +6 more
doaj +1 more source
Evolution of substrate-specific gene expression and RNA editing in brown rot wood-decaying fungi. [PDF]
, 2019 Fungi that decay wood have characteristic associations with certain tree species, but the mechanistic bases for these associations are poorly understood.
Ahrendt, Steven +10 more
core +1 more source
Identification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease. [PDF]
PLoS ONE, 2015 Gaucher disease, a recessive inherited metabolic disorder caused by defects in the gene encoding glucosylceramidase (GlcCerase), can be divided into three subtypes according to the appearance of symptoms associated with central nervous system involvement.
Hila Zigdon +5 more
doaj +1 more source
Novel homozygous GBA2 mutation in a patient with complicated spastic paraplegia [PDF]
, 2018 Hereditary spastic paraplegias (HSPs) are a heterogeneous group of neurological disorders characterized primarily by a pyramidal syndrome with lower limb spasticity, which can manifest as pure HSP or associated with a number of neurological or non ...
Bertini, Enrico +10 more
core +1 more source
Molecular Pathogenesis of Memory Impairment in Parkinson's Disease: An Exploration of Underlying Mechanisms. [PDF]
Health Sci RepABSTRACT Background and Aim Parkinson's disease (PD) is primarily known for its motor symptoms but is increasingly recognized for its substantial cognitive effects, particularly on memory. This narrative review aims to clarify the complex molecular mechanisms contributing to memory impairment in PD by integrating findings from both animal and clinical ...
Pourfridoni M +3 more
europepmc +2 more sources
Ambroxol improves lysosomal biochemistry in glucocerebrosidase mutation-linked Parkinson disease cells. [PDF]
, 2014 Gaucher disease is caused by mutations in the glucocerebrosidase gene, which encodes the lysosomal hydrolase glucosylceramidase. Patients with Gaucher disease and heterozygous glucocerebrosidase mutation carriers are at increased risk of developing ...
Abramov, AY +10 more
core +1 more source
Glucosylceramidases and malignancies in mammals
Biochimie, 2016 Sphingolipids represent a major class of lipids that are essential constituents of eukaryotic cells. They are predominantly located in plasma membrane microdomains, and play an important structural role in regulating membrane fluidity. They are also bioactive effectors involved in diverse key cellular functions such as apoptosis and proliferation.
Astudillo, Leonardo +5 more
openaire +3 more sources
Sphingolipid Distribution, Content and Gene Expression during Olive-Fruit Development and Ripening
Frontiers in Plant Science, 2018 Plant sphingolipids are involved in the building of the matrix of cell membranes and in signaling pathways of physiological processes and environmental responses.
Carla Inês +7 more
doaj +1 more source
Cytosolic Glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease [PDF]
, 2019 A new paradigm for Niemann-Pick C disease is presented where lysosomal storage leads to a deficit in cytoplasmic glucosylceramide (GlcCer) where it performs important functions.
Bhardwaj, Meenakshi +5 more
core +1 more source