Results 21 to 30 of about 2,368 (129)
Sphingolipid Distribution, Content and Gene Expression during Olive-Fruit Development and Ripening
Frontiers in Plant Science, 2018 Plant sphingolipids are involved in the building of the matrix of cell membranes and in signaling pathways of physiological processes and environmental responses.
Carla Inês +7 more
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Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease. [PDF]
PLoS ONE, 2011 The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there are no effective therapies. A potential approach is substrate reduction therapy using inhibitors of glucosylceramide synthase (GCS) to decrease the ...
Karen M Ashe +12 more
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Biomedicines, 2022 Exosomes/microvesicles originate from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of rottlerin, a polyphenol, on exosome/microvesicle secretion in a model of ...
Yessenia L. Molina +10 more
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Loss-of-Function NUBPL Mutation May Link Parkinson's Disease to Recessive Complex I Deficiency
Frontiers in Neurology, 2020 In an unbiased genome-wide screen for copy number variants (CNVs) on a cohort of Parkinson's disease (PD) patients, we identified in one patient a complex chromosomal rearrangement involving the nucleotide binding protein-like (NUBPL) gene on chromosome ...
Peggy S. Eis +4 more
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Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction. [PDF]
PLoS ONE, 2012 To determine whether changes in sphingolipid composition are associated with age-related immune dysfunction, we analyzed the core sphingolipidome (i.e., all of the metabolites through the first headgroup additions) of young and aged CD4(+) T cells. Since
Alberto Molano +9 more
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The Enigmatic Role of GBA2 in Controlling Locomotor Function
Frontiers in Molecular Neuroscience, 2017 The non-lysosomal glucosylceramidase GBA2 catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. Loss of GBA2 function results in accumulation of glucosylceramide.
Marina A. Woeste +2 more
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Oral Microbiota Identifies Patients in Early Onset Rheumatoid Arthritis
Microorganisms, 2021 Rheumatoid arthritis (RA) is the most common autoimmune inflammatory disease, and single periodontitis-associated bacteria have been suggested in disease manifestation. Here, the oral microbiota was characterized in relation to the early onset of RA (eRA)
Anders Esberg +3 more
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Frontiers in Nutrition, 2022 Obesity is a growing global health problem; it has been forecasted that over half of the global population will be obese by 2030. Obesity is complicated with many diseases, such as diabetes and cardiovascular diseases, leading to an economic impact on ...
Jiaqi Liu +5 more
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Chinese Journal of Contemporary Neurology and NeurosurgeryLipid metabolism may play a role in the onset and progression of Parkinson's disease （PD）, involving various pathological mechanisms such as abnormal folding and accumulation of α‑synuclein (α‑Syn), ferroptosis, GBA1 gene mutation, and mitochondrial ...
XU Ying, GUI Ya‑xing
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A novel mutation in the GBA2 gene in a Japanese patient with SPG46: A case report
eNeurologicalSci, 2020 Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder characterized by pyramidal weakness and spasticity of the lower limbs. SPG46, one of autosomal recessive HSP, is clinically characterized by spasticity and pyramidal weakness of the ...
Keiko Nakamura-Shindo +6 more
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