Results 11 to 20 of about 3,748 (212)
Function of saposin C in the reconstitution of glucosylceramidase by phosphatidylserine liposomes [PDF]
FEBS Letters, 1993 The function of saposin C (Sap C), a glucosylceramidase activator protein, in the enzyme stimulation by phosphatidylserine (PS) liposomes has been investigated. Using gel filtration experiments evidence was obtained for Sap C binding to PS large unilamellar vesicles (LUV) but not to glucosylceramidase.
Anna Maria Vaccaro +2 more
exaly +5 more sources
The binding of glucosylceramidase to glucosylceramide is promoted by its activator protein [PDF]
FEBS Letters, 1987 A protein activator of glucosylceramidase (EC 3.2.1.45) has been previously identified by us in human placenta [(1985) Biochim. Biophys. Acta 836, 157–166]. In the present paper we report that its function in vitro is to stimulate the binding of the enzyme to its substrate, glucosylceramide. After the purification step which frees the enzyme of most of
Anna Maria Vaccaro +2 more
exaly +4 more sources
Journal of Biological Chemistry, 2020 Cellular membranes contain many lipids, some of which, such as sphingolipids, have important structural and signaling functions. The common sphingolipid glucosylceramide (GlcCer) is present in plants, fungi, and animals. As a major plant sphingolipid, GlcCer is involved in the formation of lipid microdomains, and the regulation of GlcCer is key for ...
Fang-Cheng Bi, Nan Yao
exaly +4 more sources
Salmonella Type III Secretion Effector SrfJ: A Glucosylceramidase Affecting the Lipidome and the Transcriptome of Mammalian Host Cells. [PDF]
Int J Mol Sci, 2023 Type III secretion systems are found in many Gram-negative pathogens and symbionts of animals and plants. Salmonella enterica has two type III secretion systems associated with virulence, one involved in the invasion of host cells and another involved in maintaining an appropriate intracellular niche.
Aguilera-Herce J +5 more
europepmc +7 more sources
Journal of Medicinal Chemistry, 2014 This work details the evaluation of a number of N-alkylated deoxynojirimycin derivatives on their merits as dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. Building on our previous work, we synthesized a series of D-gluco and L-ido-configured iminosugars N-modified with a variety of hydrophobic functional groups.
Anneke Strijland +2 more
exaly +5 more sources
Glucosylceramidase Beta (GBA) Genotyping v1
, 2021 This protocol details the steps for GBA genotyping. This protocol has been adapted from the PRoBaND Clinical Consortium (incorporating methods described by Neuman et al., 2009 and Stone et al., 2000) and has been used for all publications for PRoBaND / Tracking Parkinson's describing clinical data and outcomes with respect to GBA status
Huw R. Morris, Nigel Williams
openalex +2 more sources
Identification of plasma biomarkers in a PTZ-induced Sudden Unexpected Death-like model through integrated proteomics and metabolomics methods [PDF]
Frontiers in MedicineIntroductionSudden Unexpected Death in Epilepsy (SUDEP) refers to the unexplained, sudden death of individuals with epilepsy, and its incidence is closely linked to the severity and duration of seizures.
Gaolin Zheng +6 more
doaj +2 more sources
Biodistribution of AAV1, AAV5, AAV9, and AAVDJ serotypes after intra-cisterna magna delivery in non-human primates [PDF]
Molecular Therapy: Methods & Clinical DevelopmentDelivering drugs effectively to the central nervous system (CNS) is a major challenge in drug development, including adeno-associated virus (AAV) gene therapy.
Takuro Okai +12 more
doaj +2 more sources