Results 31 to 40 of about 2,570 (187)
Fermentation, 2023 The purpose of this study was to investigate the effects of replacing a portion of whole-plant corn silage with straw on the rumen microbial community structure and carbohydrate-active enzyme activity.
Yubin Ma +6 more
doaj +1 more source
Identification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease. [PDF]
PLoS ONE, 2015 Gaucher disease, a recessive inherited metabolic disorder caused by defects in the gene encoding glucosylceramidase (GlcCerase), can be divided into three subtypes according to the appearance of symptoms associated with central nervous system involvement.
Hila Zigdon +5 more
doaj +1 more source
Glucosylceramidases and malignancies in mammals
Biochimie, 2016 Sphingolipids represent a major class of lipids that are essential constituents of eukaryotic cells. They are predominantly located in plasma membrane microdomains, and play an important structural role in regulating membrane fluidity. They are also bioactive effectors involved in diverse key cellular functions such as apoptosis and proliferation.
Astudillo, Leonardo +5 more
openaire +3 more sources
Sphingolipid Distribution, Content and Gene Expression during Olive-Fruit Development and Ripening
Frontiers in Plant Science, 2018 Plant sphingolipids are involved in the building of the matrix of cell membranes and in signaling pathways of physiological processes and environmental responses.
Carla Inês +7 more
doaj +1 more source
Glucosylceramidase Maintains Influenza Virus Infection by Regulating Endocytosis [PDF]
Journal of Virology, 2019 Influenza virus is the pathogen responsible for the second largest pandemic in human history. A better understanding of how influenza virus enters host cells may lead to the development of more-efficacious therapies against emerging strains of the virus.
Kelly Drews +11 more
openaire +2 more sources
Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease. [PDF]
PLoS ONE, 2011 The neuropathic glycosphingolipidoses are a subgroup of lysosomal storage disorders for which there are no effective therapies. A potential approach is substrate reduction therapy using inhibitors of glucosylceramide synthase (GCS) to decrease the ...
Karen M Ashe +12 more
doaj +1 more source
Biomedicines, 2022 Exosomes/microvesicles originate from multivesicular bodies that allow the secretion of endolysosome components out of the cell. In the present work, we investigated the effects of rottlerin, a polyphenol, on exosome/microvesicle secretion in a model of ...
Yessenia L. Molina +10 more
doaj +1 more source
Glucosylceramidase Beta (GBA) Genotyping v1
, 2021 This protocol details the steps for GBA genotyping. This protocol has been adapted from the PRoBaND Clinical Consortium (incorporating methods described by Neuman et al., 2009 and Stone et al., 2000) and has been used for all publications for PRoBaND / Tracking Parkinson's describing clinical data and outcomes with respect to GBA status
Huw Morris, Nigel Williams
openaire +1 more source
Loss-of-Function NUBPL Mutation May Link Parkinson's Disease to Recessive Complex I Deficiency
Frontiers in Neurology, 2020 In an unbiased genome-wide screen for copy number variants (CNVs) on a cohort of Parkinson's disease (PD) patients, we identified in one patient a complex chromosomal rearrangement involving the nucleotide binding protein-like (NUBPL) gene on chromosome ...
Peggy S. Eis +4 more
doaj +1 more source
Interaction of saposins, acidic lipids, and glucosylceramidase.
Journal of Biological Chemistry, 1990 Activity of lysosomal glucosylceramidase is stimulated by two small glycoproteins, saposin A and C, which are, together with two other similar glycoproteins, derived from a single precursor protein. This enzyme is also stimulated by naturally occurring acidic lipids, such as phosphatidylserine and gangliosides. Using highly purified glucosylceramidase,
S, Morimoto +7 more
openaire +2 more sources