Results 1 to 10 of about 11,017 (271)

Anti-biofilm and anti-glucosyltransferase effects of nano liposomal plant extracts against Streptococcus mutans. [PDF]

Sci Rep
The role of Streptococcus mutans in the initiation of caries is related to its acidogenicity, aciduricity, and polysaccharides extracellular layer production by glucosyltransferases in dental biofilms.
Radmand F, Baseri M, Memar MY, Ebrahimi A, Hamishehkar H, Asnaashari S, Naseri A, Kouhsoltani M.   +7 more
europepmc   +2 more sources

Structure, function, and pathology of protein O-glucosyltransferases [PDF]

Cell Death and Disease, 2021
Protein O-glucosylation is a crucial form of O-glycosylation, which involves glucose (Glc) addition to a serine residue within a consensus sequence of epidermal growth factor epidermal growth factor (EGF)-like repeats found in several proteins, including
Muhammad Zubair Mehboob, Minglin Lang
doaj   +3 more sources

Molecular insights into antibiofilm inhibitors of Streptococcus mutans glucosyltransferases through in silico approaches. [PDF]

Sci Rep
Streptococcus mutans, a primary cariogenic bacterium, plays a central role in dental caries, one of the most widespread chronic diseases globally. Glucosyltransferases (GTFs) are key virulence factors in this process, as they synthesize extracellular ...
Atta L, Siddiqui AR, Mushtaq M, Munsif S, Nur-E-Alam M, Ahmed A, Ul-Haq Z.   +6 more
europepmc   +2 more sources

Glucosyltransferase activity-based screening identifies tannic acid as an inhibitor of <i>Streptococcus mutans</i> biofilm. [PDF]

Front Microbiol
Dental caries is a biofilm-related chronic infectious disease. Streptococcus mutans is the core microorganism that leads to caries, with its capacity to form biofilms via glucosyltransferases (Gtfs) being the predominant virulence factor contributing to ...
Xu M, Wang X, Gong T, Yang Z, Zhang D, Ma Q, Li Y.   +6 more
europepmc   +2 more sources

Virtual Screening, Synthesis and Biological Evaluation of Streptococcus mutans Mediated Biofilm Inhibitors

Molecules, 2022
Dental caries, a global oral health concern, is a biofilm-mediated disease. Streptococcus mutans, the most prevalent oral microbiota, produces extracellular enzymes, including glycosyltransferases responsible for sucrose polymerization.
Lubna Atta, Ruqaiya Khalil, Khalid Mohammed Khan, Moatter Zehra, Faiza Saleem, Mohammad Nur-e-Alam, Zaheer Ul-Haq   +6 more
doaj   +1 more source

Involvement of NADH Oxidase in Biofilm Formation in Streptococcus sanguinis [PDF]

, 2016
Biofilms play important roles in microbial communities and are related to infectious diseases. Here, we report direct evidence that a bacterial nox gene encoding NADH oxidase is involved in biofilm formation. A dramatic reduction in biofilm formation was
Ge, Xiuchun, Kitten, Todd, Kong, Fanxiang, Liu, Jinlin, Shi, Limei, Shi, Xiaoli, Stone, Victoria, Xu, Ping   +7 more
core   +16 more sources

Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

Frontiers in Microbiology, 2021
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are the virulence determinants of cariogenic biofilms.
Yucui Liu, Yucui Liu, Yanxin Huang, Cong Fan, Cong Fan, Zhongmei Chi, Miao Bai, Luguo Sun, Li Yang, Chunlei Yu, Zhenbo Song, Xiaoguang Yang, Xiaoguang Yang, Jingwen Yi, Jingwen Yi, Shuyue Wang, Lei Liu, Guannan Wang, Lihua Zheng   +18 more
doaj   +1 more source

Glucosylation of (±)-Menthol by Uridine-Diphosphate-Sugar Dependent Glucosyltransferases from Plants

Molecules, 2021
Menthol is a cyclic monoterpene alcohol of the essential oils of plants of the genus Mentha, which is in demand by various industries due to its diverse sensorial and physiological properties. However, its poor water solubility and its toxic effect limit
Elisabeth Kurze, Victoria Ruß, Nadia Syam, Isabelle Effenberger, Rafal Jonczyk, Jieren Liao, Chuankui Song, Thomas Hoffmann, Wilfried Schwab   +8 more
doaj   +1 more source

Streptococcus mutans Membrane Vesicles Harboring Glucosyltransferases Augment Candida albicans Biofilm Development

Frontiers in Microbiology, 2020
Candida albicans, as the most common fungus in the oral cavity, is often detected in early childhood caries. Streptococcus mutans is the major etiological agent of dental caries, but the role of S. mutans on C.
Ruixue Wu, Ruixue Wu, Ye Tao, Ye Tao, Yina Cao, Yina Cao, Yan Zhou, Yan Zhou, Huancai Lin, Huancai Lin   +9 more
doaj   +1 more source

A Muti-Substrate Flavonol O-glucosyltransferases from Safflower

Molecules, 2023
To explore the complete biosynthesis process of flavonoid glycosides in safflower, specifically the key glycosyltransferase that might be involved, as well as to develop an efficient biocatalyst to synthesize flavonoid glycosides, a glycosyltransferase ...
Shuyi Qi, Beixuan He, Haotian Wang, Yaqian Duan, Lunuan Wang, Yue Gao, Meili Guo   +6 more
doaj   +1 more source