Results 1 to 10 of about 8,012 (213)

Anti-biofilm and anti-glucosyltransferase effects of nano liposomal plant extracts against Streptococcus mutans [PDF]

Scientific Reports
The role of Streptococcus mutans in the initiation of caries is related to its acidogenicity, aciduricity, and polysaccharides extracellular layer production by glucosyltransferases in dental biofilms.
Faraz Radmand, Milad Baseri, Mohammad Yousef Memar, Alireza Ebrahimi, Hamed Hamishehkar, Solmaz Asnaashari, Amirreza Naseri, Maryam Kouhsoltani   +7 more
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Water-insoluble exopolysaccharide synthesized by glucosyltransferases mediates the antibacterial activity of ClyR against Streptococcus mutans [PDF]

Journal of Oral Microbiology
Background Dental caries is a widespread global health issue strongly associated with Streptococcus mutans. Bacteriophage-derived lytic enzymes such as ClyR hold considerable promise as antibacterial potential, but the molecular mechanisms underlying ...
Qizhao Ma, Xiaowan Wang, Mai Xu, Ziyi Yang, Dian Zhang, Jiamin Chen, Tao Gong, Hang Yang, Yuqing Li   +8 more
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A novel selective medium Sucrose-Bacitracin agar 10 for accurate isolation and identification of Streptococcus mutans [PDF]

BMC Oral Health
Background To develop and evaluate Sucrose-Bacitracin agar with 10% sucrose (SB-10), a novel selective medium designed to enhance the isolation and identification of Streptococcus mutans, a key cariogenic pathogen in dental caries.
Yuwen Fang, Qizhao Ma, Wei Zhao, Nian Liu, Lei Cheng, Jing Chen, Jing Zou   +6 more
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Molecular insights into antibiofilm inhibitors of Streptococcus mutans glucosyltransferases through in silico approaches [PDF]

Scientific Reports
Streptococcus mutans, a primary cariogenic bacterium, plays a central role in dental caries, one of the most widespread chronic diseases globally. Glucosyltransferases (GTFs) are key virulence factors in this process, as they synthesize extracellular ...
Lubna Atta, Ali Raza Siddiqui, Mamona Mushtaq, Sajida Munsif, Mohammad Nur-e-Alam, Aftab Ahmed, Zaheer Ul-Haq   +6 more
doaj   +2 more sources

Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis [PDF]

Nature Communications
Collagen glucosyltransferases catalyze collagen glucosylation critical for biology and diseases, yet their structural regulation remains unclear. Here, we report crystal structures of a mimiviral collagen glucosyltransferase in its apo form and in ...
Jeong Seon Kim, Zhenhang Chen, Sara Andrea Espinosa Garcia, Christoph Buhlheller, Botao Zhang, Stephen J. Richards, Tingfei Chen, Jingjing Wu, Ronald C. Bruntz, Marisa E. Gilliam, Mitsuo Yamauchi, Bo Liang, Houfu Guo   +12 more
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Nasal immunization with Streptococcus mutans membrane vesicles and eggshell-derived hydroxyapatites elicits enhanced antigen-specific mucosal IgA responses [PDF]

Scientific Reports
Nasal vaccines characterized by secretory IgA (SIgA) induction are effective in preventing mucosal infection. SIgA induction is potentiated by mucosal adjuvants, and the exploration of new safe and effective candidates is important.
Tomomi Hashizume-Takizawa, Chihiro Mochizuki, Yuki Sakai, Koichi Nakamura, Hirotaka Kobayashi, Hidenobu Senpuku   +5 more
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The biosynthesis of trillin 6′-O-glucoside: A low-abundance yet pharmacologically active polyphyllin from Paris polyphylla [PDF]

Synthetic and Systems Biotechnology
Natural products from medicinal plants serve as an invaluable resource for drug discovery and development. However, low-abundance natural products are often understudied due to the challenges of obtaining sufficient quantities for pharmacological testing
Yaran Suo, Shuyu Li, Haining Lyu, Xin Zhao, Jiale Xing, Xin Chai, Qian Zhang, Chunjin Fu, Chengchao Xu, Jingjing Liao   +9 more
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Virtual Screening, Synthesis and Biological Evaluation of Streptococcus mutans Mediated Biofilm Inhibitors

Molecules, 2022
Dental caries, a global oral health concern, is a biofilm-mediated disease. Streptococcus mutans, the most prevalent oral microbiota, produces extracellular enzymes, including glycosyltransferases responsible for sucrose polymerization.
Lubna Atta, Ruqaiya Khalil, Khalid Mohammed Khan, Moatter Zehra, Faiza Saleem, Mohammad Nur-e-Alam, Zaheer Ul-Haq   +6 more
doaj   +1 more source

Ursolic Acid Targets Glucosyltransferase and Inhibits Its Activity to Prevent Streptococcus mutans Biofilm Formation

Frontiers in Microbiology, 2021
Streptococcus mutans (S. mutans), the prime pathogen of dental caries, can secrete glucosyltransferases (GTFs) to synthesize extracellular polysaccharides (EPSs), which are the virulence determinants of cariogenic biofilms.
Yucui Liu, Yucui Liu, Yanxin Huang, Cong Fan, Cong Fan, Zhongmei Chi, Miao Bai, Luguo Sun, Li Yang, Chunlei Yu, Zhenbo Song, Xiaoguang Yang, Xiaoguang Yang, Jingwen Yi, Jingwen Yi, Shuyue Wang, Lei Liu, Guannan Wang, Lihua Zheng   +18 more
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Streptococcus mutans Membrane Vesicles Harboring Glucosyltransferases Augment Candida albicans Biofilm Development

Frontiers in Microbiology, 2020
Candida albicans, as the most common fungus in the oral cavity, is often detected in early childhood caries. Streptococcus mutans is the major etiological agent of dental caries, but the role of S. mutans on C.
Ruixue Wu, Ruixue Wu, Ye Tao, Ye Tao, Yina Cao, Yina Cao, Yan Zhou, Yan Zhou, Huancai Lin, Huancai Lin   +9 more
doaj   +1 more source