Results 31 to 40 of about 3,651 (251)

Sex‐Specific Lasting Metabolome Effects of Adverse Gestational Conditions and Prevention by Myo‐Inositol Supplementation During Suckling

Molecular Nutrition &Food Research, EarlyView.
This graphical abstract illustrates the effects of myo‐inositol supplementation during suckling in reducing long‐term metabolic impacts from mild gestational calorie restriction (GCR). Using a metabolomics approach, 164 metabolites were identified, with greater metabolic alterations in males.
Rocío A. Martín‐Chamorro, Jean‐Charles Martin, Pedro Castillo, Mariona Palou, Andreu Palou, Ana María Rodríguez, Catalina Picó   +6 more
wiley   +1 more source

Bear bile powder ameliorates type 2 diabetes via modulation of metabolic profiles, gut microbiota, and metabolites

Frontiers in Pharmacology, 2023
Introduction: Bear bile powder (BBP) is widely used in the clinic and has a hypoglycemic effect, but its mechanism is not clear. Methods: In this study, type 2 diabetes mellitus (T2DM) rats induced by a high-sugar and high-fat diet combined with ...
Xingyuan Chen, Ke Cai, Wen Zhang, S. Su, Li-Hui Zhao, Li-ping Qiu, J. Duan   +6 more
semanticscholar   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

The gut microbiome associated with LGI1‐antibody encephalitis

Epilepsia, EarlyView.
Abstract Objective Autoimmune encephalitis is a cause of brain inflammation characterized by auto‐antibodies, which target cell surface neuronal proteins and lead to neuronal dysfunction. The most common form is associated with auto‐antibodies to leucine‐rich glioma‐inactivated 1 (LGI1) protein, the presentation of which includes frequent focal ...
Edmund Gilbert, Sophie Binks, Valentina Damato, Christopher Uy, Paula Colmenero, Mark Kelly, Mohamed Ibrahim Khalil, Marcus O'Brien, Marcus J Claesson, John F. Cryan, Norman Delanty, Sarosh R. Irani, Gianpiero L. Cavalleri   +12 more
wiley   +1 more source

Effects of Magnesium on Transcriptome and Physicochemical Index of Tea Leaves

Plants, 2023
Magnesium (Mg) is one of the essential elements for the growth of tea tree and is extremely important for its development. In this study, we investigated the effect of Mg on the transcriptome and physicochemical indexes of tea leaves, and the results ...
Ying Zhang, Qi Zhang, Yuhua Wang, S. Lin, Meihui Chen, Pengyuan Cheng, Yuchao Wang, Mengru Du, X. Jia, Haibin Wang, J. Ye   +10 more
semanticscholar   +1 more source

Structural characterisation of nucleotide sugar short‐chain dehydrogenases/reductases from the thermophilic pseudomurein‐containing methanogen Methanothermobacter thermautotrophicus ΔH

The FEBS Journal, EarlyView.
Nucleotide sugar short‐chain dehydrogenases/reductases (NS‐SDRs) are involved in pseudomurein and capsular polysaccharide formation in methanogenic Archaea. Methanothermobacter thermautotrophicus possesses several NS‐SDRs labelled Mth375, Mth380, Mth373, Mth631 and Mth1789.
Vincenzo Carbone, Linley R. Schofield, Patrick J. B. Edwards, Andrew J. Sutherland‐Smith, Ron S. Ronimus   +4 more
wiley   +1 more source

A Study of Metabolic Fate of A New Central Analgetic: 1-(M-Methoxy Phenyl)-2-Dimethyl-Aminomethylcyclohexanol (1) HCl (CG-315)

, 1973
Subcutaneously or per orally administered CG-315 was rapidly absorbed and widely distributed in rat whole body, especially in the lungs, spleen, liver and kidneys etc.
Hiro‐aki Yamamoto, Y. Masuda, H. Furuta, Z. Henmi, T. Murano   +4 more
semanticscholar   +1 more source

Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary Transient expression in Nicotiana benthamiana offers a powerful and versatile platform for rapid production of complex specialized metabolites. Steroidal glycoalkaloids (SGAs) and steroidal saponins produced by members of the Solanaceae family are known for their diverse structures and activities including antimicrobial, anticancer, antiviral ...
Sachin A. Gharat, Adam Jozwiak, Ilana Rogachev, Elinor A. Sharon, Sagit Meir, Ashok P. Giri, Asaph Aharoni   +6 more
wiley   +1 more source

Glucuronoyl Esterase of Pathogenic Phanerochaete carnosa Induces Immune Responses in Aspen Independently of Its Enzymatic Activity

Plant Biotechnology Journal, EarlyView.
ABSTRACT Microbial enzymes expressed in plants add new functionalities but occasionally trigger undesirable immune responses. Phanerochaete carnosa glucuronoyl esterase (PcGCE) hydrolyses the bond between lignin and 4‐O‐methyl‐α‐D‐glucuronic acid substituent of glucuronoxylan.
Evgeniy N. Donev, Marta Derba‐Maceluch, Xiao‐Kun Liu, Henri Colyn Bwanika, Izabela Dobrowolska, Mohit Thapa, Joanna Leśniewska, Jan Šimura, Alex Yi‐Lin Tsai, Konrad S. Krajewski, Dan Boström, Leszek A. Kleczkowski, Maria E. Eriksson, Karin Ljung, Emma R. Master, Ewa J. Mellerowicz   +15 more
wiley   +1 more source

OsSTK‐Mediated Sakuranetin Biosynthesis and Carbon Flux Orchestrate Growth and Defence in Rice

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plants balance resource energy allocation between growth and immunity to ensure survival and reproduction under limited availability. This study reveals that rice cultivars with elevated sucrose levels boost resistance to the fungal pathogen Magnaporthe oryzae by accumulating the phytoalexin sakuranetin, regulated by the transcription factor ...
Jitao Hu, Linying Li, Yao Zhao, Xueying Zhang, Hua Wang, Junmin Wang, Peng Sun, Li Jiang, Jingqi Wang, Lili Chen, Zhongjing Zhou, Jiaoyu Wang, Keke Yi, Yuqing He, Gaojie Hong   +14 more
wiley   +1 more source