Results 21 to 30 of about 89,193 (344)

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]

, 2010
Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W., Bartholomé, R., Bast, A., Dagnelie, P.C., Haenen, G., Hollman, P.C.H., Keijer, J., Kroon, P.A., Needs, P.W., Roos, D.   +9 more
core   +2 more sources

Impact of host and environmental factors on β-glucuronidase enzymatic activity: implications for gastrointestinal serotonin.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2020
The gastrointestinal tract houses a reservoir of bacterial-derived enzymes which can directly catalyze the metabolism of drugs, dietary elements, and endogenous molecules.
J. Walsh, L. Olavarría‐Ramírez, G. Lach, Marcus Boehme, T. Dinan, J. Cryan, B. Griffin, N. Hyland, G. Clarke   +8 more
semanticscholar   +1 more source

Serum beta-glucuronidase determination in normal subjects and in neurological and mental patients, a provisional report [PDF]

, 1963
Using the method given by GOLDSTEIN (1961)9 for the determination of serum beta-glucuronidase activity, this value was determined in both normal and patients with epilepsy, neuroses, psychoses and multiple sclerosis.
Plum, Claus Munk
core   +1 more source

The coordinated action of glucuronoyl esterase and α‐glucuronidase promotes the disassembly of lignin–carbohydrate complexes

FEBS Letters, 2020
Glucuronoxylans represent a significant fraction of woody biomass, and its decomposition is complicated by the presence of lignin–carbohydrate complexes (LCCs).
O. Raji, Jenny Arnling Bååth, Thu V. Vuong, J. Larsbrink, L. Olsson, E. Master   +5 more
semanticscholar   +1 more source

Inhibitory Activity of Bioactive Phloroglucinols from the Rhizomes of Dryopteris crassirhizoma on Escherichia coli β-Glucuronidase: Kinetic Analysis and Molecular Docking Studies

Metabolites, 2022
Phloroglucinols—one of the major secondary metabolites in Dryopteris crassirhizoma—exhibit various pharmacological effects, such as antiviral, antioxidant, and antidiabetic activities. This study evaluated 30 phloroglucinols isolated from the rhizomes of
Nguyen Viet Phong, Yan Zhao, Byung Sun Min, Seo Young Yang, Jeong Ah Kim   +4 more
doaj   +1 more source

Phylogenomic study of Burkholderia glathei-like organisms, proposal of 13 novel Burkholderia species and emended descriptions of Burkholderia sordidicola, Burkholderia zhejiangensis, and Burkholderia grimmiae [PDF]

, 2016
Partial gyrB gene sequence analysis of 17 isolates from human and environmental sources revealed 13 clusters of strains and identified them as Burkholderia glathei Glade (BGC) bacteria.
Cooper, Vaughn S, De Brandt, Evie, Meier-Kolthoff, Jan P, Peeters, Charlotte, Vandamme, Peter, Verheyde, Bart   +5 more
core   +3 more sources

Immunohistochemical expression of heparanase isoforms and syndecan-1 proteins in colorectal adenomas

European Journal of Histochemistry, 2016
The proteoglycan syndecan-1 and the endoglucuronidases heparanase-1 and heparanase-2 are involved in molecular pathways that deregulate cell adhesion during carcinogenesis.
J. Waisberg, T.R. Theodoro, L.L. Matos, F.B. Orlandi, R.L. Serrano, G.T. Saba, M.A.S. Pinhal   +6 more
doaj   +1 more source

Synthesis of 2-Aminopyrimidine Derivatives and Their Evaluation as β-Glucuronidase Inhibitors: In Vitro and In Silico Studies

Molecules, 2022
Currently the discovery and development of potent β-glucuronidase inhibitors is an active area of research due to the observation that increased activity of this enzyme is associated with many pathological conditions, such as colon cancer, renal diseases,
Sarosh Iqbal, Nimra Naveed Shaikh, Khalid Mohammed Khan, Shumaila Kiran, Sehrish Naz, Zaheer Ul-Haq, Shahnaz Perveen, M. Iqbal Choudhary   +7 more
doaj   +1 more source

UDP-glucuronosyltransferase genetic variation in North African populations: a comparison with African and European data

Annals of Human Biology, 2018
Background: Genetic variation in glucuronosyltransferases (UGT) is crucial in drug metabolism and risk of some diseases. Aim: To examine genetic variation in UGT in North African populations.
Apolonia Novillo, María Gaibar, Alicia Romero-Lorca, Hassen Chaabani, Nadir Amir, Pedro Moral, M. Esther Esteban, Ana Fernández-Santander   +7 more
doaj   +1 more source

Genetic diversity of b-glucuronidase activity among 14 strains of the dominant human gut anaerobe Ruminococcus gnavus

Genetics and Molecular Biology, 2006
Bacterial beta-glucuronidase activity in the gut increases the enterohepatic circulation of toxic compounds and plays a major role in the etiology of colon cancer.
Diane Beaud, Monique Ladiré, Vasco Azevedo, Chantal Bridonneau, Jamila Anba-Mondoloni   +4 more
doaj   +1 more source