Results 41 to 50 of about 63,621 (270)

Resveratrol given intraperitoneally does not inhibit the growth of high-risk t(4;11) acute lymphoblastic leukemia cells in a NOD/SCID mouse model. [PDF]

, 2011
The efficacy of resveratrol as a preventive agent against the growth of t(4;11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4;11) ALL SEM cell line.
Ducore, Jonathan M, Keen, Carl L, Newman, John W, Pedersen, Theresa L, Storms, David H, Zunino, Susan J   +5 more
core   +1 more source

Erythrocytes as Carriers of Therapeutic Enzymes. [PDF]

, 2020
Therapeutic enzymes are administered for the treatment of a wide variety of diseases. They exert their effects through binding with a high affinity and specificity to disease-causing substrates to catalyze their conversion to a non-noxious product, to ...
Bax, BE
core   +1 more source

Cultural methods of detection for microorganisms: recent advances and successes [PDF]

, 1997
Most microbiological methods require culture to allow organisms to recover or to selectively increase, and target organisms are identified by growth on specific agar media.
Jian, X., Watkins , J.
core  

Calcium/sodium exchange in purified secretory vesicles from bovine neurohypophyses [PDF]

, 1983
Purified secretory vesicles isolated from bovine neurohypophyses take up Na+ under the same circumstances where an efflux of Ca2+ takes place, suggesting a Na+/Ca2+ exchange. Potassium cannot substitute for Na+ in this process. Also, a Ca2+/Ca2+ exchange
Baker, Bers, Blaustein, Blitz, Borle, Brownstein, Böhlen, Conigrave, Gianetto, Gratzl, Gratzl, Johnson, Krieger-Brauer, Krieger-Brauer, Lever, Njus, Normann, Price, Rasmussen, Russell, Russell, Scherman, Scherman, Sillen, Suchard, Særmark, Særmark, Særmark, Thorn, Torp-Pedersen, Torp-Pedersen, van der Meulen, Vilhardt   +32 more
core   +1 more source

Rational Design, Synthesis, In Vitro, and In Silico Studies of Dihydropyrimidinone Derivatives as β-Glucuronidase Inhibitors

Journal of Chemistry, 2021
In the current study, a series of dihydropyrimidinone derivatives were rationally designed as β-glucuronidase inhibitors. These designed compounds were successfully synthesized and characterized through various spectroscopic techniques such as IR, 1H-NMR,
Somaye Karimian, Yasaman Moghdani, Mahsima Khoshneviszadeh, Somayeh Pirhadi, Aida Iraji, Mehdi Khoshneviszadeh   +5 more
doaj   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Phytohormone-mediated interkingdom signaling shapes the outcome of rice-Xanthomonas oryzae pv. oryzae interactions [PDF]

, 2015
Background: Small-molecule hormones are well known to play key roles in the plant immune signaling network that is activated upon pathogen perception. In contrast, little is known about whether phytohormones also directly influence microbial virulence ...
De Vleesschauwer, David, He, Ya-Wen, Höfte, Monica, Kojima, Mikiko, Sakakibari, Hitoshi, Venturi, Vittorio, Xu, Jing, Zhou, Lian   +7 more
core   +2 more sources

Incidence of Escherichia coli  - Glucuronidase Positive on Goat Milk

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca: Agriculture, 2016
Papers on beta- glucuronidase sensitivity and specificity for identifying Escherichia coli in sources of environment, food, water, etc. have been published since 1976. In this study we conducted a review of the incidence of E.
Zorica Voşgan, Anca Domuţa, Stela Jelea, Lucia Mihălescu, Flavia Pop   +4 more
doaj   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Green tea extract prevents CPT-11-induced diarrhea by regulating the gut microbiota

Scientific Reports, 2023
Irinotecan (CPT-11) is an anticancer drug with indications for use in treating various cancers, but severe diarrhea develops as a side effect. We investigated the effects of green tea extract (GTE) on CPT-11-induced diarrhea, focusing on β-glucuronidase ...
Risako Kon, Nobutomo Ikarashi, Arisa Yamaguchi, Yuka Teshima, Tamami Yamaguchi, Kanako Miyaoka, Moeno Fukuda, Hinata Noguchi, Rei Tomimoto, Hiroyasu Sakai, Junzo Kamei, Tomoo Hosoe   +11 more
doaj   +1 more source