Results 31 to 40 of about 43,079 (209)
PLoS ONE, 2011 A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337
Ai-Sheng Xiong +6 more
doaj +1 more source
BETA GLUCURONIDASE ACTIVITY IN DIABETES ASSOCIATED PERIODONTITIS
, 2020 Diabetes mellitus is a risk factor for development of periodontal disease with progressive periodontal destruction seen in diabetic patients. Advances in oral and periodontal disease diagnostic research are moving towards methods whereby periodontal risk
Padhye A, Gawali S, Chavan P
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British Journal of Clinical Pharmacology, EarlyView.Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen +7 more
wiley +1 more source
Theoretical investigation and design of some indole derivatives as potent β-glucuronidase inhibitors
Bulletin of the National Research Centre, 2020 Background β-glucuronidase enzyme is mostly found in plants and animals. It plays a vital role in detoxification of reactive metabolites that are interrelated to several illnesses and the growth of colon cancer.
Muhammad Tukur Ibrahim +3 more
doaj +1 more source
Modifications of β-glucuronidase as a reporter gene for protein sorting in saccharomyces cerevisiae [PDF]
, 1989 Several carboxypeptidase Y-/3-glucuronidase (CPY-GUS) plasmids were expressed in yeast. The CPY-GUS fusion proteins were inactivated during passage through the secretory pathway. This work was done in an attempt to recover GUS activity in yeast.
Leung, Keith Kai-Hung
core
Studies on β- Glucuronidase enzyme inhibition and insecticidal activity from Echinops Echinatus
, 2020 β-glucuronidase is a common enzyme which cleaves in β linkage and converts aglycone to a glucuronic acid. Studies have been made on this enzyme and a lot of work has been reported about specific inhibition of β-glucuronidase enzyme and insecticidal ...
Khawar Saeed +3 more
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Drug Testing and Analysis, EarlyView.Betamethasone concentrations in 20 horses from Japan and Germany following IV, IM, and INJ administration of betamethasone phosphate were analyzed using population pharmacokinetic modeling. For IV administration of 0.04 mg/kg q24 h, IPC and IUC were 0.012 and 0.31 ng/mL, respectively; the IUC approximated the IFHA urine ISL (0.20 ng/mL).
Taisuke Kuroda +9 more
wiley +1 more source
Glycosaminoglycan accumulation with partial deficiency of β-glucuronidase in the C3H strain of mice [PDF]
, 1977 Young (60–80 days) mice of the low β-glucuronidase strain, C3H/HeJ, showed no differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the randombred, “normal” Swiss-Webster mice of the same age.
Sandman, Robert +7 more
core +1 more source
Drug Testing and Analysis, EarlyView.Supercritical fluid chromatography was employed in the sample preparation for IRMS determinations in sports drug testing for the first time and the developed method was successfully validated. Cholesterol (CHOL) was introduced as a novel endogenous reference compound and population‐based Δ‐values were established as shown here.
Thomas Piper, Jana Drewes, Mario Thevis
wiley +1 more source
Beta-glucuronidase-mediated drug release
, 2002 The selective activation of a relatively non-toxic prodrug by an enzyme present only in the tumour should enhance the drug concentration at the tumour site and result in a better anti-tumour effect and a reduction in systemic toxicity as compared to ...
Boven, E +3 more
core +1 more source