Results 21 to 30 of about 38,854 (228)

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]

, 2010
Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W., Pieter C. Dagnelie, Needs, P.W., Paul A. Kroon, Jaap Keijer, Paul W. Needs, Keijer, J., Kroon, P.A., Roger Bartholomé, Hollman, P.C.H., Dirk Roos, Ilja C.W. Arts, Haenen, G., Peter C.H. Hollman, Dagnelie, P.C., Guido Haenen, Roos, D., Bartholomé, R., Bast, A., Aalt Bast   +19 more
core   +1 more source

Immunohistochemical expression of heparanase isoforms and syndecan-1 proteins in colorectal adenomas

European Journal of Histochemistry, 2016
The proteoglycan syndecan-1 and the endoglucuronidases heparanase-1 and heparanase-2 are involved in molecular pathways that deregulate cell adhesion during carcinogenesis.
J. Waisberg, T.R. Theodoro, L.L. Matos, F.B. Orlandi, R.L. Serrano, G.T. Saba, M.A.S. Pinhal   +6 more
doaj   +1 more source

Synthesis of 2-Aminopyrimidine Derivatives and Their Evaluation as β-Glucuronidase Inhibitors: In Vitro and In Silico Studies

Molecules, 2022
Currently the discovery and development of potent β-glucuronidase inhibitors is an active area of research due to the observation that increased activity of this enzyme is associated with many pathological conditions, such as colon cancer, renal diseases,
Sarosh Iqbal, Nimra Naveed Shaikh, Khalid Mohammed Khan, Shumaila Kiran, Sehrish Naz, Zaheer Ul-Haq, Shahnaz Perveen, M. Iqbal Choudhary   +7 more
doaj   +1 more source

PEG-mediated and Agrobacterium-mediated transformation in the mycopathogen Verticillium fungicola [PDF]

, 2002
Verticillium fungicola, a severe mycopathogen of the cultivated mushroom Agaricus bisporus, was successfully transformed using both PEG-mediated and Agrobacterium-mediated techniques.
Bailey, Andy M., Mills, P. R., Foster, Gary D., Bailey, AM, Foster, GD, Athey-Pollard, A, Burns, AC, Amey, Richard C., Mills, PR, Athey-Pollard, Anna, Burns, C. (Claire), Amey, RC   +11 more
core   +1 more source

UDP-glucuronosyltransferase genetic variation in North African populations: a comparison with African and European data

Annals of Human Biology, 2018
Background: Genetic variation in glucuronosyltransferases (UGT) is crucial in drug metabolism and risk of some diseases. Aim: To examine genetic variation in UGT in North African populations.
Apolonia Novillo, María Gaibar, Alicia Romero-Lorca, Hassen Chaabani, Nadir Amir, Pedro Moral, M. Esther Esteban, Ana Fernández-Santander   +7 more
doaj   +1 more source

Genetic diversity of b-glucuronidase activity among 14 strains of the dominant human gut anaerobe Ruminococcus gnavus

Genetics and Molecular Biology, 2006
Bacterial beta-glucuronidase activity in the gut increases the enterohepatic circulation of toxic compounds and plays a major role in the etiology of colon cancer.
Diane Beaud, Monique Ladiré, Vasco Azevedo, Chantal Bridonneau, Jamila Anba-Mondoloni   +4 more
doaj   +1 more source

Synthesis, Molecular Docking and β-Glucuronidase Inhibitory Potential of Indole Base Oxadiazole Derivatives

Molecules, 2019
β-glucuronidase is a lysosomal glycosidase enzyme which catalyzes the extracellular matrix of cancer and normal cells and the glycosaminoglycans of the cell membrane, which is important for cancer cell proliferation, invasion, and metastasis.
El Hassane Anouar, Moustapha Eid Moustapha, Muhammad Taha, Mohammed H. Geesi, Zeinab R. Farag, Fazal Rahim, Noor Barak Almandil, Rai Khalid Farooq, Muhammad Nawaz, Ashik Mosaddik   +9 more
doaj   +1 more source

Synthesis of Uronic Acid 1-Azasugars as Putative Inhibitors of a-Iduronidase, b-Glucuronidase and Heparanase

, 2022
1-Azasugar analogues of L-iduronic acid (L-IdoA) and D-glucuronic acid (D-GlcA) and their corresponding enantiomers were synthesized as potential pharmacological chaperones for mucopolysaccharidosis I (MPS I), a lysosomal storage disease caused by ...
Zach, Armstrong, Roger, Ashmus, David, Vocadlo, Vito, Ferro, Norbert, Wimmer, Marco, Maccarana, Jin-ping, Li, Gideon, Davies, Geraldine, Ler, Paul, Bernhardt, Gareth , Doherty, Yasmin, Kayal   +11 more
core   +1 more source

Assessment of gut microbial β-glucuronidase and β-glucosidase activity in women with polycystic ovary syndrome

Scientific Reports, 2023
PCOS is a prevalent endocrine disorder among women of reproductive age, characterized by hormonal imbalances and metabolic disturbances. This study explores the correlation between gut microbial β-glucuronidase and β-glucosidase and PCOS, focusing on ...
Jalpa Patel, Hiral Chaudhary, Kiransinh Rajput, Bhavin Parekh, Rushikesh Joshi   +4 more
doaj   +1 more source

Exploring Enzymatic Hydrolysis of Urine Samples for Investigation of Drugs Associated with Drug-Facilitated Sexual Assault

Pharmaceuticals, 2023
Analyzing urine is common in drug-facilitated sexual assault cases if the analysis of blood is not optimal. The efficient enzymatic pretreatment of urine is important for cleaving glucuronides and improving the detection of the parent drug.
Kathrine Skov, Sys Stybe Johansen, Kristian Linnet, Brian Schou Rasmussen, Marie Katrine Klose Nielsen   +4 more
doaj   +1 more source