Results 41 to 50 of about 31,424 (230)

Synthesis, in vitro β-glucuronidase inhibition of benzoxazole bearing thiosemicarbazide derivatives along with in silico molecular docking study

Results in Chemistry
This study was aimed to design and synthesize hybrid analogues of benzoxazole bearing thiosemicarbazide analogues 1–15 as promising β-Glucuronidase inhibitory activity using D-saccharic acid 1,4-lactone as the reference inhibitor.
Fazal Rahim, Rafaqat Hussain, Shazia Subhan, Hayat Ullah, Sundas Mumtaz, Shoaib Khan, Amjad Hussain, Tayyiaba Iqbal, Naveed Iqbal, Faisal Nawaz, Obaid Ur Rahman Abid, Mounir M. Bekhit, May Salem Alnbaheen, Alanood S. Algarni, Saltanat Aghayeva   +14 more
doaj   +1 more source

A Comprehensive Review on Nutrition, Phytochemistry, Pharmacology and Food Application Perspectives of Bioactive Rich Superfruits

Future Postharvest and Food, EarlyView.
The review critically evaluated and compared the selected superfruit phytochemistry, their bioactive composition and the key health benefits majorly emphasizing the antioxidant potential. It has highlighted the translational challenges in formulating functional foods by addressing the issues related to delivery system, bioavailability mechanism and the
Sharath Kumar Nagaraja, Javid Iqbal Mir, Mahendra Kumar Verma, Aamir Hussain Dar   +3 more
wiley   +1 more source

Activity guided discovery of dual inhibitors of α-glucosidase and β-glucuronidase from the leaves of Millettia pachycarpa Benth

Journal of Enzyme Inhibition and Medicinal Chemistry
Type 2 diabetes mellitus (T2DM) and cancers are two globally prevalent diseases which can increase the incidence of each other. Intestinal α-glucosidase and β-glucuronidase are key targets for glycaemic control and chemotherapy detoxification ...
Yanxi He, Huanran Xu, Shaoqian Tan, Jing Long, Hui Lei, Ling Xiao, Xiaoyi Qi, Mingming Deng, Xia Xiong, Jingcan You, Liangliang Zhu, Muhan Lü, Sicheng Liang   +12 more
doaj   +1 more source

Bioinformatics: A rational combine approach used for the identification and in-vitro activity evaluation of potent β-Glucuronidase inhibitors.

PLoS ONE, 2018
Identification of hotspot drug-receptor interactions through in-silico prediction methods (Pharmacophore mapping, virtual screening, 3DQSAR, etc), is considered as a key approach in drug designing and development process.
Maria Yousuf, Nimra Naveed Shaikh, Zaheer Ul-Haq, M Iqbal Choudhary   +3 more
doaj   +1 more source

Evaluation of Acephate Metabolites Generated by Zebrafish (Danio rerio) Using LC–HRMS and Metabolomics Approach

Journal of Applied Toxicology, EarlyView.
ABSTRACT Acephate is an organophosphate insecticide widely used. This pesticide can be metabolized into methamidophos, a molecule highly toxic. Both have demonstrated the ability to promote serious toxic effects on nontarget organisms and have been identified in surface waters around the world. Therefore, it is important to understand their behavior in
Mariana Laiz Silva de Lima, Lucas Rodrigues Cunha, Karina Taciana Santos Rubio, Maria Elvira Poleti Martucci   +3 more
wiley   +1 more source

Phenoxyacetohydrazide Schiff Bases: β-Glucuronidase Inhibitors

Molecules, 2014
Phenoxyacetohydrazide Schiff base analogs 1–28 have been synthesized and their in vitro β-glucouoronidase inhibition potential studied. Compounds 1 (IC50 = 9.20 ± 0.32 µM), 5 (IC50 = 9.47 ± 0.16 µM), 7 (IC50 = 14.7 ± 0.19 µM), 8 (IC50 = 15.4 ± 1.56 µM),
Waqas Jamil, Shagufta Perveen, Syed Adnan Ali Shah, Muhammad Taha, Nor Hadiani Ismail, Shahnaz Perveen, Nida Ambreen, Khalid M. Khan, Muhammad I. Choudhary   +8 more
doaj   +1 more source

Causal Link Between Obstructive Uropathy, Estradiol, and Risk of Breast Cancer: Insights From Observational Evidence and Genetic Association Analyses

Medicine Advances, EarlyView.
Based on the observational analysis of UK Biobank clinical data, urinary tract obstruction showed a significant negative association with breast cancer risk, accompanied by substantially lower systemic estradiol levels in individuals with obstruction.
Hailu Wang, Yingying Dai, Wenhai Pan, Kaiyuan Mao, Zhiyi Zhang, Yan Zhang, Yifan Chen, Yiyin Zhang   +7 more
wiley   +1 more source

Continuous Spectrophotometric Assay for β-Glucuronidase

BioTechniques, 2001
A continuous spectrophotometric assay has been developed for detecting β-glucuronidase activity. In the assay, Para-nitrophenyl β-d-glucuronide is cleaved to yield a chromophoric product. With the commercial E.
Sanjukta Aich, Louis T.J. Delbaere, Ridong Chen   +2 more
doaj   +1 more source

Seedling resistance and chemical defenses against Psylliodes chrysocephala: the roles of seed age and sinapinic acid in Sinapis alba and Brassica napus

Pest Management Science, EarlyView.
The cabbage stem flea beetle (Psylliodes chrysocephala) is a major pest of winter oilseed rape (Brassica napus). We tested B. napus and Sinapis alba seedlings for feeding resistance and underlying chemical defenses. S. alba was least damaged, while metabolite profiles revealed resistance‐linked compounds, highlighting breeding potential for insect ...
Daniel Rüde, Samantha M Cook, Bernd Ulber, Tobias Pöhnl, Michael Rostás   +4 more
wiley   +1 more source

Upregulation of Jasmonate-Inducible Defense Proteins and Differential Colonization of Roots of Oryza sativa Cultivars with the Endophyte Azoarcus sp.

Molecular Plant-Microbe Interactions, 2006
The endophyte Azoarcus sp. strain BH72 expresses nitrogenase (nif) genes inside rice roots. We applied a proteomic approach to dissect responses of rice roots toward bacterial colonization and jasmonic acid (JA) treatment.
Lucie Miché, Federico Battistoni, Sabrina Gemmer, Maya Belghazi, Barbara Reinhold-Hurek   +4 more
doaj   +1 more source