Results 151 to 160 of about 42,320 (201)
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Hydrolysis of Morphine Glucuronide
Journal of Forensic Sciences, 1974Abstract In procedures requiring the quantitative analysis for total morphine in body fluids there is a need to liberate the bound drug, and for the hydrolysis of conjugates in urine there are alternative methods of acid or enzyme hydrolysis.
F, Fish, T S, Hayes
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2021
Glucuronidation catalyzed by uridine 5′-diphospho-glucuronosyltransferase (UGT) is the most common phase II metabolism. The UGTs can severely limit a drug's exposure and generate reactive metabolites, leading to toxicity. This chapter provides a brief overview of the current understanding of the UGT enzyme family, followed by various medicinal ...
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Glucuronidation catalyzed by uridine 5′-diphospho-glucuronosyltransferase (UGT) is the most common phase II metabolism. The UGTs can severely limit a drug's exposure and generate reactive metabolites, leading to toxicity. This chapter provides a brief overview of the current understanding of the UGT enzyme family, followed by various medicinal ...
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Intermediates for Glucuronide Synthesis: 7-Hydroxycoumarin Glucuronide
Journal of Chemical Research, 1997A convenient synthesis of the important metabolite 7-hydroxycoumarin glucuronide 3 is presented, including a first report of the β-imidate 11β, together with new preparations of the iodosugar 6 and α-imidate 11α: stability data on 11α and 11β are also given, and the importance of carefully controlled hydrolysis in the last step of the preparation of 3 ...
Richard T. Brown +2 more
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On the formation of carbamate glucuronides
Xenobiotica, 1990(1990). On the formation of carbamate glucuronides. Xenobiotica: Vol. 20, No. 1, pp. 133-134.
L P, Delbressine +3 more
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Drug glucuronidation in humans
Pharmacology & Therapeutics, 1991Glucuronidation is a major metabolic pathway for a large number of drugs in humans. Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene UDP-glucuronosyltransferase family. It is believed that a number (unspecified at present) of glucuronosyltransferase isozymes, which probably differ in terms of substrate ...
J O, Miners, P I, Mackenzie
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Acta Pharmacologica et Toxicologica, 1978
Abstract Uptake studies, using radioactive labelled glucuronides, have demonstrated the ability of 4‐nitrophenyl glucuronide and phenolphthalein glucuronide to enter isolated rat hepatocytes. Of these glucuronides 4‐nitrophenyl glucuronide was distributed in a similar manner to O‐methylglucose, whereas phenolphthalein glucuronide was bound to cellular ...
A, Norling +3 more
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Abstract Uptake studies, using radioactive labelled glucuronides, have demonstrated the ability of 4‐nitrophenyl glucuronide and phenolphthalein glucuronide to enter isolated rat hepatocytes. Of these glucuronides 4‐nitrophenyl glucuronide was distributed in a similar manner to O‐methylglucose, whereas phenolphthalein glucuronide was bound to cellular ...
A, Norling +3 more
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The Effect of Chloroform Inhalation on Hepatic Glucuronidation and De-Glucuronidation Mechanisms
Drug and Chemical Toxicology, 1980The effect of 2, 4, 6 or 8 exposures to chloroform vapour on hepatic glucuronidating (UDPGA transferase) and de-glucuronidating (beta-glucuronidase) levels has been studied in rats. Successive treatments progressively decreased hepatic UDPGA transferase to a minimum of 53% of the control level.
I D, Capel +3 more
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Microsomal Acyl Glucuronidation: Enzyme-Kinetic Studies with Labile Glucuronides
Pharmacology, 2008Because of the labile nature of acyl glucuronides under physiologic conditions, metabolic rates of formation calculated using traditional methods may be confounded by concomitant rates of degradation. True metabolic formation rates may be approximated by stabilization of the metabolic product or by purifying the metabolite and calculating its ...
H, Spahn-Langguth, L Z, Benet
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Scintigraphic imaging with a peptide glucuronide in rabbits: 99mTc- exorphin C glucuronide
Applied Radiation and Isotopes, 2007A peptide glucuronide (Exorphin C glucuronide) was labeled with 99mTc using glucoheptonate (GH) as a bifunctional chelating agent. Scintigraphic imaging was performed in male Albino rabbits. Exorphin C glucuronide showed rapid and efficient labeling with 99mTc using glucoheptonate as a bifunctional chelate.
Ertay T. +5 more
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