Results 161 to 170 of about 42,461 (214)
Some of the next articles are maybe not open access.
Glucuronidation of apomorphine
Life Sciences, 2000Apomorphine, a dopaminergic receptor agonist, is largely used in the therapy of Parkinson's disease. In this study, we characterized the glucuronidation of apomorphine and other catechols in rat liver and brain microsomes, using UDP-[U-14C]glucuronic acid and separation of the glucuronides formed by a thin layer chromatographic method.
R S, El-Bachá +4 more
openaire +2 more sources
Xenobiotica, 1991
1. To expedite direct studies on phase II metabolites of fluphenazine, pure fluphenazine or 7-hydroxyfluphenazine were incubated with a rabbit hepatic microsomal immobilized enzyme system. After purification and recrystallization a high yield (60%) of 7-hydroxy-beta-D-O-glucuronyl-fluphenazine was obtained. 2.
C J, Jackson, J W, Hubbard, K K, Midha
openaire +2 more sources
1. To expedite direct studies on phase II metabolites of fluphenazine, pure fluphenazine or 7-hydroxyfluphenazine were incubated with a rabbit hepatic microsomal immobilized enzyme system. After purification and recrystallization a high yield (60%) of 7-hydroxy-beta-D-O-glucuronyl-fluphenazine was obtained. 2.
C J, Jackson, J W, Hubbard, K K, Midha
openaire +2 more sources
Drug Metabolism and Disposition, 2012
Glucuronidation reaction is catalyzed by mammalian uridine diphosphoglucuronosyl transferases by using uridine diphosphoglucuronic acid as a cosubstrate. Conjugation of glucuronic acid to nucleophilic functional groups in chemical entities results in formation of glucuronides. As anticipated, a number of nucleophilic functional groups such as hydroxyl,
openaire +2 more sources
Glucuronidation reaction is catalyzed by mammalian uridine diphosphoglucuronosyl transferases by using uridine diphosphoglucuronic acid as a cosubstrate. Conjugation of glucuronic acid to nucleophilic functional groups in chemical entities results in formation of glucuronides. As anticipated, a number of nucleophilic functional groups such as hydroxyl,
openaire +2 more sources
Glucuronidation and the Transport of the Glucuronide Metabolites in LLC-PK1 Cells
Molecular Pharmaceutics, 2005Formation and transport of glucuronide metabolites were studied in LLC-PK1 cells. Glucuronidation of 17beta-estradiol, 1-naphthol, mycophenolic acid, and 4-methylumbelliferone was examined in microsomes prepared from LLC-PK1 cells, human livers, human kidneys, and human intestines.
Jae H, Chang, Leslie Z, Benet
openaire +2 more sources
Current Drug Metabolism, 2011
This review on isomers or acyl glucuronides (iso-glucuronides) updates earlier reviews, and attempts to place in context the advances that have been made, especially over the last 15 years. The essential chemistry behind the intramolecular acyl migration and anomerization reactions of acyl glucuronides has been appreciated for 30 years.
openaire +5 more sources
This review on isomers or acyl glucuronides (iso-glucuronides) updates earlier reviews, and attempts to place in context the advances that have been made, especially over the last 15 years. The essential chemistry behind the intramolecular acyl migration and anomerization reactions of acyl glucuronides has been appreciated for 30 years.
openaire +5 more sources
2021
Glucuronidation catalyzed by uridine 5′-diphospho-glucuronosyltransferase (UGT) is the most common phase II metabolism. The UGTs can severely limit a drug's exposure and generate reactive metabolites, leading to toxicity. This chapter provides a brief overview of the current understanding of the UGT enzyme family, followed by various medicinal ...
openaire +1 more source
Glucuronidation catalyzed by uridine 5′-diphospho-glucuronosyltransferase (UGT) is the most common phase II metabolism. The UGTs can severely limit a drug's exposure and generate reactive metabolites, leading to toxicity. This chapter provides a brief overview of the current understanding of the UGT enzyme family, followed by various medicinal ...
openaire +1 more source
Hydrolysis of Morphine Glucuronide
Journal of Forensic Sciences, 1974Abstract In procedures requiring the quantitative analysis for total morphine in body fluids there is a need to liberate the bound drug, and for the hydrolysis of conjugates in urine there are alternative methods of acid or enzyme hydrolysis.
F, Fish, T S, Hayes
openaire +2 more sources
Intermediates for Glucuronide Synthesis: 7-Hydroxycoumarin Glucuronide
Journal of Chemical Research, 1997A convenient synthesis of the important metabolite 7-hydroxycoumarin glucuronide 3 is presented, including a first report of the β-imidate 11β, together with new preparations of the iodosugar 6 and α-imidate 11α: stability data on 11α and 11β are also given, and the importance of carefully controlled hydrolysis in the last step of the preparation of 3 ...
Richard T. Brown +2 more
openaire +1 more source
On the formation of carbamate glucuronides
Xenobiotica, 1990(1990). On the formation of carbamate glucuronides. Xenobiotica: Vol. 20, No. 1, pp. 133-134.
L P, Delbressine +3 more
openaire +2 more sources
Drug glucuronidation in humans
Pharmacology & Therapeutics, 1991Glucuronidation is a major metabolic pathway for a large number of drugs in humans. Conjugation of drugs and other chemicals with glucuronic acid is catalyzed by the multigene UDP-glucuronosyltransferase family. It is believed that a number (unspecified at present) of glucuronosyltransferase isozymes, which probably differ in terms of substrate ...
J O, Miners, P I, Mackenzie
openaire +2 more sources