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Morphine‐3‐glucuronide prevents tolerance to morphine‐6‐glucuronide in mice
European Journal of Pain, 1997Daily subcutaneous (s.c.) pretreatment with morphine‐3‐glucuronide (6 mg/kg) was found to reduce morphine‐6‐glucuronide (4 mg/kg s.c.)‐induced antinociception, with no decrease in the effect over 5 days. Morphine‐6‐glucuronide administration (4 mg/kg s.c.) on Day 6, without morphine‐3‐glucorinide pretreatment, results in a significant increase in ...
Faura, Clara C. +2 more
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Clinical Pharmacokinetics, 1999
During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only determined by ontogenic regulation but also by genetic processes which add to the variability of drug metabolism during different stages of childhood.
de Wildt, Saskia +3 more
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During human development impressive changes in drug disposition occur. An important determinant of drug clearance is metabolism, something that is not only determined by ontogenic regulation but also by genetic processes which add to the variability of drug metabolism during different stages of childhood.
de Wildt, Saskia +3 more
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The mechanism of glucuronide formation
Biochemical Pharmacology, 1961Abstract The mechanism of formation of simple glucuronides in animal tissues is reviewed. So far glucuronide synthesis has been found to occur in liver and to a lesser extent in kidney of a number of animal species. Of the mammals studied cat liver slices formed very little glucuronide. More recently glucuronide formation has been discovered to occur
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Biochemical pharmacology, 1991
Diflunisal (DF) is metabolized primarily to its acyl glucuronide (DAG), phenolic glucuronide (DPG) and sulphate (DS) conjugates. Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
King A.R., Dickinson R.G.
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Diflunisal (DF) is metabolized primarily to its acyl glucuronide (DAG), phenolic glucuronide (DPG) and sulphate (DS) conjugates. Whereas DPG and DS are stable at physiological pH, DAG is unstable, undergoing hydrolysis (regeneration of DF) and rearrangement (intramolecular acyl migration to the 2-, 3- and 4-O-acyl-positional isomers).
King A.R., Dickinson R.G.
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19. EFFECT OF GLUCURONIDES ON THE GLUCURONIDE BIOSYNTHESIS
Acta Paediatrica, 1970O. HÄNNINEN, J. MARNIEMI
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General Pharmacology: The Vascular System, 1998
Françoise Guéraud, Alain Paris
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Françoise Guéraud, Alain Paris
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Synthesis of the glucuronide of Carazolol
Carbohydrate Research, 1988M, Rudolph, H, Steinhart, B, Helpap
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The synthesis of O-glucuronides
Natural Product Reports, 1998A V, Stachulski, G N, Jenkins
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